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Health Unchained

Health Unchained

Health Unchained hosts conversations with blockchain/healthcare professionals who are disrupting the health industry.

Latest From Series

Ep. 81: Federated Learning with DLT – Mathieu Galtier (CPO Owkin)

Mathieu Galtier, PhD – Neuroscience and computer science (applied mathematics) background. Chief Product Officer of Owkin which was founded in 2016 and has quickly emerged as a leader in bringing AI and ML technologies to the healthcare industry. We’ll be talking about how blockchain technology and federated learning systems are creating amazing new opportunities in medical research and development. LinkedIn https://www.linkedin.com/in/mgaltier/ Guest Twitter: https://twitter.com/m_galtier Research: https://www.researchgate.net/profile/Mathieu-Galtier MELLODDY: https://www.imi.europa.eu/projects-results/project-factsheets/melloddy Owkin • Origins of Owkin and the healthcare interest - life science company - research oriented - really want to cure cancer o Medical data & Clinical predictive models o Connect platform for Federated Learning • Owkin Tech stack overview o Data prep o Infra: Kubernetes o Application layer: Substra (python, Hyperledger fabric) o Algorithms: any python ML frameworks (pytorch, tensorflow etc) • open source foundation to host Substra framework for distributed computation ML for Healthcare • Why is ML relevant for Healthcare? o Precision medicine: customization of treatment to individual patients based on their medical data. o• Clinical Trials Research challenges and opportunities oFederated Learning for Healthcare • What is Federated Learning? o Model training across distributed datasets. Data is never shared. (opposition centralized computation vs traveling models) o Can you describe how federated learning can solve some of our privacy and security concerns with personal data? o HealthChain project o Melloddy project • What is the HealthChain project's main objective? • MELLODDY consortium - Owkin, NVIDIA, and King’s College London - Have you reached your goals? What's new with this collaboration? • Academic collaboration → HealthChain o Industrial coopetition → Melloddy • BLockchain in Federated Learning • Why is a blockchain relevant for Federated Learning? What is in the blockchain? o Trustless permission regime → smart contracts for details governance / data access regimes o Traceability & reproducibility (no 3rd party to trust) → good for certification o Decentralized orchestration → increase security; no shadow computation o Tokenization of data value through contribution score for training models o Private vs public blockchains: we needed a consortium blockchain o How can blockchain-orchestrated federated learning enable a new method of building AI models? o Models have an identity card describing their genealogy. Their performance can be assessed on 3rd party datasets → models are production / certification ready o Models are the most accurate possible. They serve as the basis (for transfer learning) for numerous data modalities: histology, genomics, chemistry... •What do you believe in that most people would disagree with? o There is no free will • Favorite book that has influenced you o Foundation by Isaac Asimov. Psychohistory: 2 scales individual and population. • Keys to ML in Healthcare  Collaboration  Confidentiality  Compliance News Corner https://www.wired.com/story/microsoft-decentralized-id-blockchain/ Occording to sources, Microsoft has been working on a decentralized identity solution since 2017 and has slowly built out the infrastructure over the past few years.. At the recent Ignite conference, Microsoft announced that it will launch a public preview of its “Azure Active Directory verifiable credentials” spring of 2021. In the NHS pilot, for example, health care providers can request access to professional certifications from existing NHS health care workers, who can in turn choose to allow that access, streamlining a process for transferring to another facility that previously required a much more involved back and forth. U Health Unchained Links Website: https://healthunchained.org Telegram: t.me/healthunchained Twitter: twitter.com/Healthunchaind
March 15, 2021

Ep. 80: Clinical Sciences and Operations Innovation – Disa Lee Choun (UCB)

Disa Lee Choun, head of Global clinical sciences and operations innovation at UCB, a Belgium-based multi-billion dollar pharmaceutical company. Disa is also co-leading the first PHUSE blockchain working group (non-profit) and was named Top 100 tech women, advisor entrepreneur by the Financial times 100 most influential BAME leader. Disa has years of experience working on technology and innovation especially in the pharmaceutical industry. Her passion is working on closing the gap for patients with unmet needs and exploring/implementing the right technologies (Blockchain, IoT, AI/machine learning, robotics, data discovery tools, and others) to accelerate the implementation of End to End patient solution. Prior to joining the pharmaceutical industry, Disa was a co-founder of an IT company. She has an EMBA and B.S. in Pharmaceutical Chemistry. Guest LI: https://www.linkedin.com/in/disa-l-95bb981/ Company website: https://www.ucb.com/ PHUSE website: https://phuse.global/ Show Notes •Introduction to Disa's background •Why did you get into chemistry and pharma? •How does your experience in pharma shape your understanding of clinical research innovation? •Role as Head of Global Clinical Sciences and Operations at UCB •Smart Contracts for clinical trials •Wearables, IOT, and sensors to improve clinical trials •Incentive mechanisms for better clinical trials •How important is community development for the new "blockchain-enabled" business models. •Favorite scientist of all time •Favorite Book – 7 Seven Habits of Highly Efficient People by Stephen Covey and The Tipping Point by Malcolm Gladwell •Final takeaways News Corner https://www.bostonglobe.com/2021/02/19/business/cape-cod-healthcare-receives-bitcoin-donations-totaling-800k/ An anonymous donor donated bitcoin to Cape Cod Healthcare, a hospital system in my state of Massachusetts. On January 28th and on February 19, the donor, (who has previously donated USD to the hospital), sent about $400k in bitcoin to Cape Cod Healthcare. That’s a total of about $800k in bitcoin which the hospital immediately converted to USD. Health Unchained Links Website: https://healthunchained.org Telegram: t.me/healthunchained Twitter: twitter.com/Healthunchaind
February 28, 2021

Ep. 79: Smart Vaccination Passports – Ain Aaviksoo, MD, MPH (CMO Guardtime)

Ain Aaviksoo, MD, MPH, Chief Medical Officer of Estonia-based Guardtime Health which has rolled out a COVID19 vaccine passport technology called VaccineGuard. Ain has worked as Undersecretary for E-services and Innovation for Estonian government overseeing the digital transformation and innovation of health care, labor and social matters. Dr Aaviksoo obtained MD from University of Tartu and MPH from Harvard University. He has earlier work experience as a physician, senior level civil servant, international level consultant on large system transformation and technology adoption in healthcare, health policy researcher, CEO of public policy think-tank Praxis and as a health-tech entrepreneur. Dr Aaviksoo has published over 20 peer-reviewed articles and contributed into several book chapters on health policy and e-health, he is also regularly presenting as invited keynote speaker on digital services and health care innovation at international events. He is lecturing in various universities on innovation and technology in healthcare. Guest info: https://www.linkedin.com/in/ainaaviksoo/ Guardtime Website: https://guardtime.com/ Show notes •Introduction to Ain's background •What drove you to the healthcare industry? •How did you first hear about blockchain technology? •COVID-19 Vaccination rate statistics and updates globally •COVID-19 Vaccine supply chain expectations •What is the vision for Guardtime as a company? •What is the impact of COVID-19 on pharma supply chain and on Guardtime? •Can you briefly describe Guardtime's services/products/platforms and their technology stacks? oMIDA cybersecurity – work with Verizon oZero-Trust system oGuardtime KSI platform oBlockchain Protocols oVaccineGuard What will be the experience for a regular person getting vaccinated? What are your company milestones goals for 2021? •Integration with medical records •Naturally infected/immune people oHSX - Life Sciences oKSI Cash - Central Bank Digital Currency (CBDC) •Experience working with the Estonian government and the WHO •Any feedback from beta-testers of your platform? •What is Guardtime's business model? •Who are your company partners and major investors? •How would you describe the company culture at Guardtime? Are you hiring? •Outlook for 2021 and beyond •Most influential books you've read – The Information: A History, a Theory, a Flood by James Gleick. Team of Teams : New Rules of Engagement for a Complex World by Stanley McChrystal •Final Takeaways News Corner https://www.npr.org/sections/goatsandsoda/2021/02/10/966304438/up-against-mutants-who-says-astrazeneca-vaccine-is-still-a-good-bet. In recent months, there have been more reports of new variants of the coronavirus across different parts of the world. In South Africa, there were plans to distribute millions of AstraZeneca-Oxford covid vaccines (viral vector genetically modified virus type) until some new evidence suggested the vaccine provided “minimal protection” against mild or moderate cases involving the B.1.351 variant also known as 501.V2. The plan would be to still rollout some of the AstraZeneca vaccine but in limited quantities and to monitor recipients closely to see how well it's working. In terms of doses that have so far been purchased, AstraZeneca is currently the world's largest source of COVID vaccines, scheduled to deliver more than 2 billion doses this year. One thing that seems safe to say is getting a vaccine now is better than waiting for a perfect vaccine a year from now. Health Unchained Links Website: https://healthunchained.org Telegram: t.me/healthunchained Twitter: twitter.com/Healthunchaind
February 21, 2021

Ep. 78: Detecting Counterfeit Hair Extensions in Africa – Shadrack Kubyane (CEO Coronet Blockchain)

Shadrack Kubyane, co-founder of Coronet Blockchain, is a former Deloitte management consultant. He founded the company with his wife, Pretty, to track the supply chain of human hair extensions to salons and individuals in South Africa. Coronet Blockchain leverages IBM Hyperledger technologies to secure the supply chain for human hair extensions. Guest Info Website: https://www.coronetblockchain.com/ LinkedIn: https://www.linkedin.com/in/shadrack-kubyane-04629b12/ Show Notes •Introduction of Shadrack's background and experience •Origins of Coronet Blockchain •Problems that Coronet Blockchain is trying to solve •Hair market in Africa and globally - supply chain •Buyers and sellers of human hair •How can hair extensions improve self-esteem and possibly mental health? •Technology stack •How is the IBM blockchain eco-system? •What kind of data is collected in the Coronet Blockchain marketplace? •Do you need to use blockchain for your marketplace? Why? •What are the main challenges and opportunities that your company faces today? •Company traction •Growth marketing strategies in Africa •Roadmap for 2021 and beyond •If it’s not too personal, what would you consider to be your biggest mistake? •Favorite book that most influenced your universe – Finding a Way to Win: The Principles of Leadership, Teamwork, and Motivation by Bill Parcells •Final takeaways News Corner https://www.mobihealthnews.com/news/emea/astrazeneca-estonia-participate-vaccineguard-pilot In January of 2021, AstraZeneca in Estonia partnered with data security and blockchain firm, Guardtime, to participate in their VaccineGuard pilot. Iceland, Hungary, and Estonia are the first countires to sign up to the new platform supporting the global covid-19 vaccination program. Vaccination passports and the idea of immunity passports are hot topics as people try to get back to normal life. This is just one of many types of digital health technologies being used to facilitate the global rollout of the Covid19 vaccines. While this is a great step forward for the world, there are still many questions about how effective the vaccines are against new coronavirus variants. Tune into Health Unchained episode 79 where we do a deep dive into this pilot project with the Chief medical officer of Guardtime as my guest. Health Unchained Links Website: https://healthunchained.org Telegram: t.me/healthunchained Twitter: twitter.com/Healthunchaind
February 7, 2021

Ep. 77: Data Ethics and Compliance – Wendy M. Charles, PhD, CIP, CCRP, CBP

Wendy M. Charles, PhD, CIP, CCRP, CBP is a researcher and regulatory compliance scientist with expertise in managing clinical research operations, quality assurance, and implementation of health information technologies. She has 28 years of research experience; 16 years of management experience with industry-sponsored and federally funded research. Wendy is Chief Scientific Officer at BurstIQ, co-chair of the IEEE Standards Development Working group for blockchain in healthcare and life sciences, and has contributed to numerous other blockchain/healthcare publications. BurstIQ Website: www.burstiq.com Blockchain Compliance by Design: Regulatory Considerations for Blockchain in Clinical Research: https://www.frontiersin.org/articles/10.3389/fbloc.2019.00018/full We talk about how we can start encouraging an ethics by design approach to building software and how dynamic consent management can provide more control over a patient’s own health data. Related episode: https://soundcloud.com/healthunchained/ep-56-securing-health-connections-frank-ricotta-ceo-burstiq IEEE HEALTHCARE VIRTUAL SERIES: BLOCKCHAIN & AI: https://attend.ieee.org/healthcare-blockchain-ai/ Show Notes •Introduction to Wendy's background •What drove you to the healthcare world? •How did you first hear about blockchain technology? •How does your academic research experience influence your perspectives in healthcare infotech industry? •Digital tattoos for temporary health monitoring •Impact of COVID-19 on Clinical research operations •Importance of Ethics by Design •World leadership summit link - https://worldleadersummit.com/topicscategories/blockchain/ •Dynamic Consent management, broad and specific consent •Describe your role as CSO at BurstIQ •What tactics is BurstIQ employing to address data privacy and personal ownership of one's data? •Customers like Intermountain Healthcare saved ~$90M over three years by using BurstIQ: https://www.burstiq.com/burstiq-brings-90-million-case-study-to-blockchain-through-intermountain-healthcare-spin-off-empiric-health/ •What are the biggest barriers to blockchain adoption in healthcare? •Balancing between regulatory compliance and technology innovation •Most influential book you've read – The Patient Will See You Now by Dr. Eric Topol •What are your thoughts about the singularity that is supposed to happen in 2045? •If you had to have micro chip implanted in your body, where would you want it to be implanted? •Thoughts on Neuralink technology •Final Takeaways News Corner https://deepmind.com/blog/article/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology Alphabet’s decade old DeepMind artificial intelligence system has essentially solved a 50 year old grand challenge in biology. That problem is known as the protein folding problem. Proteins are the building blocks and operate all our functional biology systems. They are large complex molecules made up of chemical chains and amino acids. This is important because, right now, in order to figure out how a specific protein looks like and how it physically conforms in 3D space, scientists typically use X-Ray crystallography techniques which costs over $100k and takes up to a year to complete. There are currently over 200 million proteins in the main database and only about 170,000 have their 3D structures mapped out, a fraction of the 200M. This research is currently being peer-reviewed for final publication and scientists are absolutely excited about exploring this amazing technology for the advancement of scientific knowledge. Health Unchained Links Website: https://healthunchained.org Telegram: t.me/healthunchained Twitter: twitter.com/Healthunchaind
December 5, 2020

Ep. 76: Patient-Driven Real World Data – Robert Chu (CEO Embleema)

Robert Chu is the Co-founder & CEO of Embleema. He is the former SVP of Global Technology for IQVIA & has created & managed data networks in over 20 countries in the U.S., Asia & Europe. Robert and I talk about the tremendous value of provable, secure real world data that can be directly shared by patients to improve bio-statistical models. We also discuss his recent business partnership with Alira Health and the origins of the HIVE data analytics platform. Embleema Website: https://embleema.com/ Disclaimer: The Health Unchained podcast is for informational and entertainment purposes only and we are not providing any sort of legal, financial, or medical advice. Please do your own research and due diligence before making any important decisions related to these matters. Topics Overview •Introduction to Robert's background •What drove you to the healthcare industry? •Experience at IBM, IMS Health, and IQVIA •How did you first hear about blockchain technology? •What is the vision for Embleema? Why did you start it? •Impact of COVID-19 on on Embleema •Epilepsy Foundation partnership and Epilepsy Digital Engagement Navigator (EDEN) •Long-term studies are difficult to track •Why should people care about real world evidence/data? •Can you describe Embleema's services/products/platforms and their technology stacks? •Hyperledger •HIVE – High Performance Integrated Virtual Environment – data repository and analytics platform built by Dr. Vahan Simonyan who transferred HIVE property to Embleema https://en.wikipedia.org/wiki/High-performance_Integrated_Virtual_Environment •Tracking patient consent •What tactics are you employing to address data privacy and personal ownership of one's data? •Any feedback from beta-testers of your platform? •What are the biggest barriers to blockchain adoption in healthcare? •Synthetic control arms in clinical studies – simulation of placebo group •Embleema's business model? •Company partners and major investors? •Alira Health Partnership goals •How would you describe the company culture at Embleema? •Outlook for 2021 and beyond •Favorite DLT projects doing important work •Most influential book you've read – The Lorax by Dr. Seuss •Thoughts about the singularity that is supposed to happen in 2045 •If you had to have micro chip implanted in your body, where would you want it to be implanted? •Final Takeaways News Corner https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-covid-19-test-self-testing-home On November 17, 2020, the FDA issued an emergency use authorization for the first COVID-19 diagnostic at-home self-test which provides rapid results. The Lucira COVID-19 All-In-One Test Kit is a molecular (real-time loop mediated amplification reaction) single use test that is intended to detect the novel coronavirus SARS-CoV-2 that causes COVID-19. The Lucira COVID-19 All-In-One Test Kit test has been authorized for home use with self-collected nasal swab samples in individuals age 14 and older who are suspected of COVID-19 by their health care provider. Health Unchained Links Website: https://healthunchained.org Telegram: t.me/healthunchained Twitter: twitter.com/Healthunchaind
November 23, 2020

Health Unchained

Health Unchained features insights from the top healthcare innovators, entrepreneurs, and executives who are applying blockchain technology solutions to disrupt the health industry. We discuss their strategies, challenges, and unique experiences in this exciting new field.

Blockchain technology has the potential to create a new layer of trust, reducing the friction to participate in a healthcare network. Combined with other emerging technologies, blockchain can dramatically improve population health management, medical supply chain, health-monitoring devices, genetics research, and other health-related sectors. A diverse mix of healthcare leaders and blockchain experts is needed to accelerate the adoption of blockchain-based solutions that our healthcare system so desperately needs. The field includes economists, technologists, healthcare providers, policymakers, and financial institutions.

Listen to Health Unchained to learn about the impact that blockchain technology is having, and will continue to have, on the healthcare industry.
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Host

Ray Dogum

Ray Dogum

Ray Dogum is the producer and host of the Health Unchained podcast. On his show, he interviews leaders in the blockchain/healthcare industry where he covers topics such as health data integrity management, efficiency improvement opportunities in healthcare administration, and the future of decentralization. He also manages the deployment of enterprise-scale telehealth solutions for Health Systems at American Well, a telemedicine company based in Boston.

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