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Impulse – Meeting Healthcare Pioneers

Impulse – Meeting Healthcare Pioneers

The podcast that democratizes medical technology and meets the people who are transforming this field.

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#13 – Catalyzing drug discovery using organ-on-a-chip models – Bas Trietsch – Mimetas

Developing a new drug is a tough and strenuous endeavour, requiring investments that go beyond $1 billion and sometimes up to 15 years of time. On top of that, only 1 out of 10 drug candidates successfully passes clinical trial testing and regulatory approval. The Dutch company Mimetas, specialized in the use of organ-on-a-chip technology, aims to address exactly this challenge by accelerating this laborious process and making it more predictable. Their expertise actually lies in the development of in-vitro human tissue models (including diseases) which recapitulate the cellular complexity but also the biochemical and mechanical cues that make up the real tissues from our body. Such models can then be used as a powerful experimental platform for drug discovery, since they reflect our actual biology so well. Bas Triestch is one of the three founders from Mimetas (alongside Jos Joore and Paul Vulto) who saw in the early 2010s the potential to leverage organ-on-a-chip methods at scale for the benefit of drug discovery, leading them to become the most innovative Dutch company in 2022! In this episode, Bas takes us behind the scenes of the fascinating science that they are driving at Mimetas, the impact that they are having on the R&D efforts from some of the biggest players in the biotech industry, but also the shift that they have operated as a company, starting as a “hardware” provider and gradually becoming a specialized scientific service firm. Timeline: 01:35 - Bas’ background and the origins of Mimetas centered around new drug discovery approaches 05:31 - What organ-on-a-chip technology means and how it serves the development of new human tissue and disease models 09:05 - The OrganoPlate® as the key platform providing scalability and reproducibility for the study of such models 15:40 - Merging organoids and organ-on-a-chip technologies in a unique platform, the OrganoPlate® Graft 24:03 - Moving from better understanding diseases, through medication guidance, and up to personalized medicine 28:47 - Mimetas’ mission in accelerating the development of new treatments and finding the right drugs for the right patients 34:50 - Dealing with substantial amount of experimental data 39:24 - Shifting Mimetas’ business model from selling hardware components to offering specialized scientific services in the field of drug discovery What we also talked about with Bas: Leiden University Hans Clevers Roche Galapagos Trans-Epithelial Electrical Resistance (TEER) Wnt signaling pathway We cited with Bas some of the past episodes from the series: #5 - Transforming diagnostics through spatial biology - Déborah Heintze - Lunaphore #8 - Using organoids to transform drug discovery - Nikolce Gjorevski - Roche As mentioned in the episode, you can learn more about Mimetas and the field of organ-on-a-chip engineering through their website. Based on Bas’ recommendation, we also invite you to check out this review to get a deeper understanding of the field and where it stands at the moment. If you want to get in touch with Bas, feel free to contact him per email at [email protected] or through LinkedIn. If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or per email at [email protected] And if you liked the episode, don’t hesitate to share it, subscribe to the podcast and leave a positive review on streaming platforms! Finally, you can follow our activities through our website, over LinkedIn, Twitter or on Instagram!
November 28, 2022

[EXTRACT] – Bas Trietsch on the radical benefits of using organ-on-a-chip models early in drug discovery

To discover the whole episode type “#13 - Catalyzing drug discovery using organ-on-a-chip models - Bas Trietsch - Mimetas" on your streaming platform.
November 28, 2022

#12 – Unleashing the power of digital health – Daniel Kraft – Digital.Health

Daniel Kraft is a surprising and admirable figure in the digital health landscape. Originally trained as a physician in internal medicine and pediatrics, he then distinguished himself by his research work focusing on regenerative medicine, while at the same time initiating several entrepreneurial projects in the medtech space. RegenMed Systems is one of them, a company that he founded and which led him to create a new type of medical device to facilitate bone marrow harvest procedures. IntelliMedicine is another one, where he aims to create a system enabling patients to 3D print their own medication at home, avoiding the intake of multiple pills on a daily basis. Aside from his own entrepreneurial endeavours, he advises several Fortune-50 and digital health-related startups, and is on the board of Healthy.io. As one of the most renowned ambassadors of digital health, he is driven by the conviction that innovation in this space can only result from the synergies of disciplines and technologies that may initially be totally distant from the medical sphere. Through his activities at the Singularity University or through the program Exponential Medicine that he initiated, he brings together brilliant minds from a broad range of specialties who come together to explore convergent and rapidly developing technologies, to develop relevant applications in healthcare. Often called upon to speak to the future of health, medicine and technology, he has already given multiple TED and TEDMED Talks, and delivered keynotes to a wide array of organizations on those subjects. We talked with Daniel about his early days in the healthcare world, why he decided to study medicine and orient himself on this path, his perspective on the importance of collaboration and boldness when it comes to creating new digital health solutions, what the future looks like from his lens, but also how he manages to stay on top of things while keeping a healthy lifestyle! Timeline: 00:59 - Daniel’s background moving from medical studies, through biomedical research, entrepreneurship and thought leadership in digital health 03:56 - What drove Daniel to start a career in healthcare 05:54 - How converging new digital technologies can benefit medical progress 09:00 - The shift in adoption within the medical community towards digital health 10:49 - The types of medical data available these days to advance our understanding and management of diseases 14:30 - Establishing a general database to reference all things digital health - Digital.Health 20:16 - Zooming in on RegenMed Systems and IntelliMedicine 26:25 - A lookout on Daniel’s potential future projects in healthcare 31:54 - Daniel’s tips and secrets on his (almost) endless source of energy and drive What we also talked about with Daniel: Bits & Pretzels HealthTech Xolair Stanford Byers Center for Biodesign NASA IBM Watson CRISPR/Cas9 Continuum Health Ventures Digitale Gesundheitsanwendungen (DiGA) You can learn more about Daniel’s activities through his website (we recommend you to subscribe to his weekly newsletter), and you can follow him on LinkedIn and Twitter. For a deep-dive into digital health solutions, we recommend you to consult Digital.Health, the database that Daniel and his team put together and which regroups most of the solutions already available out there. In case you want to experience the thrill of digital health and share your ideas with some of the brightest minds in the field, check out NextMed.Health, the conference in San Diego curated by Daniel and his team from March 13 to 16 next year. If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or by email: [email protected] And if you liked the episode, don’t hesitate to share it, subscribe to the podcast, leave a positive review on streaming platforms and follow our activities on LinkedIn, Instagram, Twitter as well as on our website!
November 1, 2022

[EXTRACT] – Daniel Kraft on IntelliMedicine and 3D printing your own pills at home

To discover the whole episode type “#12 - Unleashing the power of digital health - Daniel Kraft - Digital.Health" on your streaming platform.
November 1, 2022

#11 – Turning the lab into a wearable platform – Esmeralda Megally – Xsensio

Miniaturizing the lab to allow for the continuous analysis of proteins and hormones circulating in our body through a wearable. This is the aim of Xsensio - a Swiss startup developing the Lab-on-Skin(c) platform - which will enable in the future to continuously track compounds present in the interstitial fluid, right underneath our skin. It is in essence a similar concept as the established continuous glucose measurement devices (which are nowadays moving from pure medical applications to consumer-oriented wellness programs), the difference being the type of biomarkers that the Lab-on-Skin(c) platform will enable to monitor - proteins and hormones on-body, continuously and in real-time - opening applications ranging from cardiology to oncology, in the hospital setting or at home. Esmeralda Megally (CEO of the company) shares with us her vision around personalized medicine and which role the Lab-on-Skin(c) platform will play in this regard. With passion, she explains us the concepts behind the functioning of this surprising technology, what it takes to bring it to the market, and reveals the potential synergies that it may have in the future with the current wearables that are already part of our daily living. Timeline: 02:20 - Esmeralda’s background and how it led to the creation of Xsensio 09:14 - The unmet need that Xsensio is addressing with its Lab-on-Skin(c) platform 13:51 - The applications where the Lab-on-Skin(c) platform will play a role 17:28 - The functioning of the Lab-on-Skin(c) platform and its components 22:50 - What lies ahead of Xsensio before making its first product commercialized 28:09 - Combining the Lab-on-Skin(c) platform with traditional wearables data 29:57 - Defining a medical product development roadmap in an emerging field and how to deal with accompanying uncertainty What we also talked about with Esmeralda: Fitbit Apple Watch Bill & Melinda Gates Foundation Lab for Youth Mental Health NANOLAB Veri Supersapiens C-reactive protein Troponin T Mayo Clinic Rea Diagnostics We cited with Esmeralda some of the past episodes from the series: #4 - Fighting sepsis with nanoengineered beads to filter the blood - Lukas Langenegger - Hemotune If you want to know more about Xsensio, we invite you to consult their website and follow their activities on LinkedIn or Twitter. As mentioned by Esmeralda in the episode, have a read at this paper from Nature Biotechnology if you want to know more about the field of biosensing. You can get in touch with Esmeralda through LinkedIn or by email: [email protected] If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or by email: [email protected] And if you liked the episode, don’t hesitate to share it, subscribe to the podcast and leave a positive review on streaming platforms! You can follow our activities through our website, over LinkedIn, or on Instagram!
October 19, 2022

[EXTRACT] – Esmeralda Megally on the emergence of wearable biosensors

To discover the whole episode type “#11 - Turning the lab into a wearable platform - Esmeralda Megally - Xsensio" on your streaming platform.
October 19, 2022

Impulse - Meeting Healthcare Pioneers

Impulse invites listeners to meet the people shaping the current medical advancements through in-depth conversations about their field of expertise and the journey that took them where they are now. The podcast aims to democratize ongoing advances in medical technology and to introduce listeners to some of its key actors.
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Host

Mathieu Chaffard

Mathieu Chaffard

Mathieu is a French biomedical engineer, trained at the Swiss Federal Institute of Technology in Lausanne.

Passionate about medical technology applied to cardiac indications, he has occupied different technical roles in Europe, including Development Engineer for B. Braun in Berlin and Field Specialist for Abbott in Paris, before moving to project management in the digital health space for Roche Diagnostics in Zürich.

Wishing to share his passion for medical progress on a broad scale and driven by an ongoing desire to learn more about its aspects, he has decided to create his own show where he talks with entrepreneurs, researchers and physicians about their personal journey and the innovative technologies they are developing to transform patients' lives.

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