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Impulse – Meeting Healthcare Pioneers

Impulse – Meeting Healthcare Pioneers

The podcast that democratizes medical technology and meets the people who are transforming this field.

Latest From Series

#7 – Redefining motor rehabilitation with digital neurotherapeutics – Naveed Ejaz – MindMaze

Naveed Ejaz is VP Product Strategy and Clinical Development (formerly Director of Digital Therapies) at MindMaze, the very first unicorn from Switzerland, pioneering the fascinating field of digital neurotherapeutics. Underneath these fluffy terms lies the concept of “software-as-a-medicine”, where pieces of code come together to drive a behavioural intervention, enabling patients suffering from neurological diseases to improve their condition. In the area of neurology where pharmaceutical and medical device solutions have been limited, this field opens up promising perspectives in terms of extended care delivery, stronger engagement from patients towards their treatment plans, and facilitated care coordination. We talked with Naveed about how video games could be leveraged to create an engaging therapy for the benefits of patients suffering from neurological diseases, the challenges that companies involved in the field of digital therapeutics face, MindMaze’s vision to build an integrated platform delivering cutting-edge rehabilitation programs for patients, and why all of that is not purely about technology but rather engaging the patients as much as all healthcare professionals surrounding them. We also get a sneak peek at the activities led within MindMaze Labs, the R&D division of the company partnering with institutions like Formula One to understand better how the brain works under extreme situations! Timeline: 04:43 - Naveed’s background and what drove him towards neuroscience and neurorehabilitation 13:03 - What digital neurotherapeutics are and what “software-as-a-medicine” entails 20:30 - Conceptual acceptability towards digital neurotherapeutics in healthcare 23:38 - The benefits of gamification in neurorehabilitation therapies 29:44 - How the rehabilitation therapies from MindMaze are designed 42:57 - The key characteristics of a therapeutic video game that keeps patients engaged 47:15 - Rehabilitating fine dextrous motion versus gross movement 52:04 - Naveed’s role as VP Product Strategy and Clinical Development (formerly Director of Digital Therapies) 55:03 - Initiatives led by MindMaze Labs R&D center and partnering with Formula One What we also talked about with Naveed: BrainGate John Krakauer Johns Hopkins University MindMaze Labs Formula One If you want to know more about MindMaze, we invite you to consult their website and follow their activities on LinkedIn. As mentioned by Naveed in the episode, if you want to know more about the field of digital neurotherapeutics and the latest trends in that regard, have a look at Rock Health (and subscribe to their newsletter) and MobiHealthNews. You can get in touch with Naveed through LinkedIn or by email: [email protected] If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or by email: [email protected] And if you liked the episode, don’t hesitate to share it, subscribe to the podcast and leave a positive review on streaming platforms! You can follow our activities through our website, over LinkedIn, or on Instagram!
August 1, 2022

[EXTRACT] – Naveed Ejaz on the concept of software-as-a-medicine

To discover the whole episode type "#7 - Redefining motor rehabilitation with digital neurotherapeutics - Naveed Ejaz - MindMaze" on your streaming platform.
August 1, 2022

[SPECIAL EDITION] – Saul Marquez – Outcomes Rocket

This is a special episode where we receive Saul Marquez, host of Outcomes Rocket, one of the leading podcast series in the healthcare space, having already interviewed key opinion leaders from the field throughout more than 1000 episodes! The format of the podcast is slightly different from the episodes produced so far as part of Impulse, with shorter conversations and a stronger business focus. The range of topics covered though is unprecedented: with testimonials from people working in the industry (from startups to big corporations), Academia, healthcare providers, or in insurance firms. It’s hard not to say that they’ve probably already covered all the potential topics the field may offer! Outcomes Rocket is available at the following platforms: Apple Podcasts Spotify Google Podcasts Overcast You can find out more about Outcomes Rocket through their website, we also invite you to follow their activities on LinkedIn and subscribe to their newsletter. If you want to reach out to Saul, feel free to contact him through LinkedIn! If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or by email: [email protected]  And if you liked the episode, don’t hesitate to share it, subscribe to the podcast and leave a positive review on streaming platforms!
July 14, 2022

#6 – Bringing back walking to paraplegics – Jocelyne Bloch – .NeuroRestore

Bringing back mobility to those who lost it. This is the challenge that Jocelyne Bloch, neurosurgeon at the CHUV, together with the neuroscientist Grégoire Courtine from EPFL and their teams at .NeuroRestore and Onward set out to address. A decade after demonstrating that the technology developed by Prof. Courtine’s lab was able to bring back lower limb mobility to paraplegic rats, it has now been applied to humans in a research context through their joint work with phenomenal outcomes: most paraplegic patients implanted with the stimulation system they have developed were able to retrieve significant mobility of their lower limbs, enabling them to stand, walk and even climb stairs! Based on an electrode array coupled to a pulse generator (both fully implantable) remotely controlled, the system delivers selective stimulation of the spinal cord at the locations where the lower limb muscles are activated, in a sequence that replicates the mobility patterns that abled people demonstrate. Images of patients having experienced this technology, moving out of their wheelchair to stand and walk, have been seen throughout the world, and the hope that it brings for those concerned is immense, considering also the other applications that it could open for the rehabilitation of the upper limbs or for blood pressure regulation. In the latest episode from Impulse, we had the chance to sit down with Jocelyne and exchange with her on the infancy of this therapy, where she takes us through its working principle, the challenges that come along with bringing such a technology from the lab to the market, as well as on the life-changing benefits it may hold for patients in the future. With great humility, she also talks about how she manages to combine her clinical practice as a functional neurosurgeon, to leading a research group composed of over 80 collaborators, all of that while raising two children and with a husband at home! Timeline: 05:20 - Jocelyne’s background and what led her to functional neurosurgery 08:18 - Approach taken to enable paraplegic rats to walk again and moving towards human applications 14:55 - The first human implantation 17:20 - Towards autonomous mobility renewal 18:25 - The STIMO study focusing on mobility and upcoming trials 21:03 - Managing expectations of patients 23:20 - Making a viable therapy with a reasonable rehabilitation training phase 26:17 - Leveraging potential synergies with exoskeletons 27:23 - Current technological constraints 28:34 - Origins and purpose of .NeuroRestore, and the close collaboration with Onward 33:03 - Towards upper limbs and hands rehabilitation therapies 34:10 - Retrieving sensory feedback thanks to the current therapy 35:23 - Adding brain-computer interaction layers to the current therapy 37:56 - Staying on top of things when working as a neurosurgeon, leading a clinical research center, and a family life 39:41 - Evolving as a woman in the field of neurosurgery What we also talked about with Jocelyne: Grégoire Courtine Patrick Aebischer Jean-Guy Villemure Bogdan Draganski Baroreflex Neuroprosthetics Neuroplasticity EEG ECoG CHUV UNIL EPFL Medtronic Elon Musk We cited with Jocelyne some of the past episodes from the series: #3 – Augmenting the lives of paraplegics with exoskeletons – Tristan Vouga – Twiice #5 – Transforming diagnostics through spatial biology – Déborah Heintze – Lunaphore If you want to know more about .NeuroRestore, we invite you to consult their website. We also invite you to follow their activities on LinkedIn. If you are interested in learning more about the startup Onward, we invite you to check out their website as well as their LinkedIn page. You can contact Jocelyne by email: [email protected] If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or by email: [email protected]
July 5, 2022

[EXTRACT] – Jocelyne Bloch on decoding brain signals to enable mind-controlled stimulation of the spinal cord

To discover the whole episode type “#6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore” on your streaming platform.
July 5, 2022

#5 – Transforming diagnostics through spatial biology – Déborah Heintze – Lunaphore

Transforming our understanding of how our immune system works and how certain pathologies like cancer unfold: that is the mission to which Lunaphore has committed since 2014. Through a cutting-edge platform capable of accelerating complex staining and imaging procedures, the Swiss startup is pioneering what is now named “spatial biology”, recognized by the journal Nature as Method of the Year 2020. Applicable to many disease areas, the field carries great hopes in bringing to light new insights that will accelerate drug discovery and drive the development of personalized therapies in the long run. Its power resides in the possibility to analyze multiple biomarkers in parallel, while preserving the spatial properties of the tissue studied. Alongside Ata Tuna Ciftlik and Diego Dupouy, Déborah Heintze is one of the three co-founders of Lunaphore. She joined the adventure soon after the completion of her curriculum in biomedical engineering, the same day that an offer was made to her by a large company for a position that would have been synonymous with stability and comfort from the outset. The gamble paid off, as she now leads as Chief Marketing Officer the product and marketing efforts of the startup, which has been recognized many times as one of the most innovative and promising emerging companies in the Swiss ecosystem. She takes us through the origins of the project, explaining how the opportunity to co-found the startup arose, how the technology they developed functions, and how spatial biology will revolutionize the way we understand immunology and the promises it holds in the fight against many diseases. Timeline: 01:50 - Déborah’s background and evolution within Lunaphore since its creation 04:48 - How Lunaphore emerged from a PhD thesis 06:49 - How the opportunity co-found a startup emerged 10:22 - What the technology from Lunaphore is about 12:27 - Paving the way of spatial biology for diagnostic purposes 16:48 - The promise that spatial biology holds in our understanding of pathologies like cancer and how Lunaphore is supporting it 20:04 - The features and functioning of LabSat® and COMET™ 22:50 - Dealing with the analysis of large pathology data volumes 25:24 - Transitioning from research applications to clinical ones 27:50 - Deploying LabSat® and COMET™ in labs while making sure the onboarding remains flawless for users 29:29 - The time and efforts required to build these platforms from scratch up to their market launch 33:37 - Moving towards new applications and disease areas 35:08 - How the technology from Lunaphore is transforming the staining and imaging workflows from labs 38:39 - Evolving as a woman in the medical technology entrepreneurial sphere What we also talked about with Déborah : EPFL Technology Transfer Office Harvard-MIT Health Sciences and Technology CHUV Spatial biology Immunostaining Microfluidics Cytometry Omics DistalMotion Sophia Genetics We cited with Déborah some of the past episodes from “Impulse - Meeting Healthcare Pioneers”: #2 - Treating liver cancer with surgical robotics - Lucien Blondel - Quantum Surgical If you want to know more about Lunaphore, we invite you to consult their website. As mentioned in the episode, we strongly recommend you to check out their blog which aims to democratize spatial biology and all of its aspects in a simple yet informative manner. We also invite you to follow their activities on LinkedIn or through their newsletter (subscription link available through the company website). You can contact Déborah through LinkedIn or by email: [email protected] If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or by email: [email protected] And if you liked the episode, don’t hesitate to share it, subscribe to the podcast and leave a positive review on streaming platforms!
May 31, 2022

Impulse - Meeting Healthcare Pioneers

Impulse invites listeners to meet the people shaping the current medical advancements through in-depth conversations about their field of expertise and the journey that took them where they are now. The podcast aims to democratize ongoing advances in medical technology and to introduce listeners to some of its key actors.
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Host

Mathieu Chaffard

Mathieu Chaffard

Mathieu is a French biomedical engineer, trained at the Swiss Federal Institute of Technology in Lausanne.

Passionate about medical technology applied to cardiac indications, he has occupied different technical roles in Europe, including Development Engineer for B. Braun in Berlin and Field Specialist for Abbott in Paris, before moving to project management in the digital health space for Roche Diagnostics in Zürich.

Wishing to share his passion for medical progress on a broad scale and driven by an ongoing desire to learn more about its aspects, he has decided to create his own show where he talks with entrepreneurs, researchers and physicians about their personal journey and the innovative technologies they are developing to transform patients' lives.

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