Newsletter
NEJM This Week – Audio Summaries

NEJM This Week – Audio Summaries

New medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

All Episodes

NEJM This Week — September 29, 2022

Featuring articles on a bionic pancreas in type 1 diabetes, bronchodilators in symptomatic tobacco-exposed persons, acetazolamide in acute decompensated heart failure, and a new target for CAR T cells in myeloma; a review article on gastroesophageal reflux disease; a case report of a newborn girl with hypoglycemia; and Perspective articles on the war-zone mentality, on intradermal vaccination for monkeypox, on product hopping in the drug industry, and on a hidden crisis. Supplement to the New England Journal of Medicine, Vol. 387, No. 13.
September 28, 2022
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NEJM This Week — September 22, 2022

Featuring articles on glycemic outcomes of glycemia reduction, microvascular outcomes of glycemia reduction, dapagliflozin in heart failure with preserved ejection fraction, and an antisense oligonucleotide for SOD1 ALS; a review article on Burkitt’s lymphoma; a case report of a man with chronic diarrhea and autoimmune enteropathy; and Perspective articles on the law of licensure and quality regulation, on pushing back with pills, and on the seeds of ignorance. Supplement to the New England Journal of Medicine, Vol. 387, No. 12.
September 21, 2022
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NEJM This Week — September 15, 2022

Featuring articles on a polypill for secondary cardiovascular prevention, anticoagulation in atrial fibrillation with rheumatic heart disease, aggressive or moderate hydration in acute pancreatitis, and enteral glutamine for burn injuries; a review article on Covid-19 vaccines; a case report of a man with headache and progressive neurologic dysfunction; and Perspective articles on protecting pregnant people from climate change, on professional civil disobedience, on closing the public health ethics gap, and on finding a new mantra. Supplement to the New England Journal of Medicine, Vol. 387, No. 11.
September 14, 2022
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NEJM This Week — September 8, 2022

Featuring articles on an open-source automated insulin delivery system in type 1 diabetes, closed-loop therapy in type 1 diabetes, litifilimab for systemic lupus erythematosus, routine functional testing after PCI, metagenomic sequencing and infectious disease, and race correction and the x-ray machine; a review article on personality disorders; a case report of a man with confusion, headache, and fever; and Perspective articles on emergency department ethics in a post-Roe era, on EMTALA for pregnancy-related emergencies, and on science, competing values, and trade-offs. Supplement to the New England Journal of Medicine, Vol. 387, No. 10.
September 7, 2022
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NEJM This Week — September 1, 2022

Featuring articles on FFR versus intravascular ultrasonography to guide PCI, nirmatrelvir for Covid-19 during the omicron surge, antiretroviral HIV treatment in pregnancy, regimens for drug-resistant tuberculosis, and on building Black wealth; a review article on chronic urticaria; a Clinical Problem-Solving on telescoping the diagnostic process; and Perspective articles on what Dobbs means for patients with breast cancer, on the escalating cybersecurity threat to health care, on “fertility fraud” legislation, on updated health warnings for alcohol, and on losing contact. Supplement to the New England Journal of Medicine, Vol. 387, No. 9.
August 31, 2022
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NEJM This Week — August 25, 2022

Featuring articles on the clinical features of monkeypox in humans, the treatment of diabetic macular edema, ublituximab in relapsing multiple sclerosis, olokizumab for rheumatoid arthritis, and on when silence disrupts; a review article on lesions of the ovary and fallopian tube; a case report of a woman with cystic lung disease; and Perspective articles on the physician–patient relationship, on hospital care for substance use disorder, and on improving the use of FDA advisory committees. Supplement to the New England Journal of Medicine, Vol. 387, No. 8.
August 24, 2022
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NEJM This Week — August 18, 2022

Featuring articles on glycemic criteria for the diagnosis of gestational diabetes, a randomized trial of metformin, ivermectin, and fluvoxamine for Covid-19, and children with acute hepatitis of unknown cause; a review article on neuromyelitis optica spectrum disorder; a case report of a woman with headache and blurred vision; and Perspective articles on confronting health worker burnout, on tecovirimat and the treatment of monkeypox, on framing traumatic injury as a chronic condition, and on professionals as targets in the culture wars. Supplement to the New England Journal of Medicine, Vol. 387, No. 7.
August 17, 2022
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NEJM This Week — August 11, 2022

Featuring articles on redirecting T cells against myeloma cells, the removal of small kidney stones and relapse, the treatment of severe alpha1-antitrypsin deficiency, and BNT162b2 protection against omicron in children; a review article on bronchiectasis; a case report of a man with perianal and penile ulcers, pain, and rash; and Perspective articles on race and ethnicity in Covid risk assessments, on understanding Covid vaccine efficacy over time, on noncompete agreements, on bringing sickle-cell treatments to sub-Saharan Africa, and on a critical shortage of iodinated contrast material. Supplement to the New England Journal of Medicine, Vol. 387, No. 6.
August 10, 2022
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NEJM This Week — August 4, 2022

Featuring articles on a monoclonal antibody to prevent malaria infection, monoclonal antibody therapy in Parkinson’s disease, and dulaglutide in youths with type 2 diabetes; a review article on spina bifida; a Clinical Problem-Solving on diagnostic aspirations; and Perspective articles on building a national public health system in the U.S., on a preview of the dangerous future of abortion bans, on the end of Roe v. Wade, and on code words. Supplement to the New England Journal of Medicine, Vol. 387, No. 5.
August 3, 2022
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NEJM This Week — July 28, 2022

Featuring articles on supplemental vitamin D and incident fractures, brentuximab vedotin in advanced Hodgkin’s lymphoma, litifilimab for cutaneous lupus erythematosus, genetic protection against liver disease, and on lawmakers v. the scientific realities of human reproduction; a review article on tobacco addiction; a case report of a man with hypoglycemia; and Perspective articles on the history of health law in the United States, on primary care and financial risk, and on achieving the Triple Aim for sexual and gender minorities. Supplement to the New England Journal of Medicine, Vol. 387, No. 4.
July 27, 2022
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NEJM This Week — July 21, 2022

Featuring articles on tirzepatide for weight loss in adults with obesity, pembrolizumab in triple-negative breast cancer, Covid-19 vaccination in children 5 to 11 years of age, and gene therapy for hemophilia B; a review article on obesity in pregnancy; a case report of a woman with cavitary lung lesions; and Perspective articles on communicating statistics on climate change, on Medical Device User Fee reauthorization, and on grieving in a pandemic. Supplement to the New England Journal of Medicine, Vol. 387, No. 3.
July 20, 2022
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NEJM This Week — July 14, 2022

We discuss the latest in medical research and ideas.
July 13, 2022
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NEJM This Week — July 7, 2022

Featuring articles on trastuzumab deruxtecan in HER2-low breast cancer, effects of previous infection and vaccination on symptomatic omicron infections, and a report on porcine-to-human cardiac transplantation; review articles on pulmonary embolism and on the vaccine-hesitant moment; a Clinical Problem-Solving on the young and the breathless; and Perspective articles on physicians spreading misinformation on social media, on dietary supplements and institutionalizing misinformation, and on the portal. Supplement to the New England Journal of Medicine, Vol. 387, No. 1.
July 6, 2022
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NEJM This Week — June 30, 2022

Featuring articles on restricted intravenous fluid in septic shock, an oncolytic virus for pediatric pontine glioma, ibrutinib for untreated mantle-cell lymphoma, and on the potency of a KRAS silent variant; a review article on mantle-cell lymphoma; a case report of a man with vision changes; and Perspective articles on nineteen days in America, on a comprehensive Covid-19 response, on the solution shop and the production line, and on being without question. Supplement to the New England Journal of Medicine, Vol. 386, No. 26.
June 29, 2022
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NEJM This Week — June 23, 2022

Featuring articles on PD-1 blockade in locally advanced rectal cancer, a vaccine against respiratory syncytial virus, a vitamin C infusion in adults with sepsis, and reducing administrative harm in medicine; a review article on Philadelphia chromosome–positive acute lymphoblastic leukemia; a case report of a woman with jaundice and chronic diarrhea; and Perspective articles on racial disparity in breast-cancer mortality, on enrollee premiums in Medicaid, on a data infrastructure for clinical trial diversity, on medicalizing the Constitution, and on unexpected closure. Supplement to the New England Journal of Medicine, Vol. 386, No. 25.
June 22, 2022
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NEJM This Week — June 16, 2022

Featuring articles on circulating tumor DNA and adjuvant therapy in colon cancer, the prevention of anal cancer, Chapare hemorrhagic fever in Bolivia, immune tolerance after sequential stem-cell and kidney transplantation, and potentiating the T cell; a review article on climate change, fossil-fuel pollution, and children’s health; a case report of a woman with recurrent fractures; and Perspective articles on research to move policy, on climate change in the Supreme Court, and on medical readers and literary plague. Supplement to the New England Journal of Medicine, Vol. 386, No. 24.
June 15, 2022
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NEJM This Week — June 9, 2022

Featuring articles on chronic traumatic encephalopathy in military personnel, a PDE4 inhibitor for idiopathic pulmonary fibrosis, a monoclonal-antibody combination to prevent Covid-19, natural and hybrid immunity to SARS-CoV-2, and emerging technologies in health and medicine; a review article on the diagnosis and treatment of frostbite; a case report of a boy with chest pain; and Perspective articles on a radical treatment for insulin pricing, on the tobacco wars’ lessons for the vaccination wars, on physicians as political pawns, and on the high cost of cancer drugs under Medicare Part D. Supplement to the New England Journal of Medicine, Vol. 386, No. 23.
June 8, 2022
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NEJM This Week — June 2, 2022

Featuring articles on an albuterol–budesonide rescue inhaler in asthma, the efficacy of a plant-based SARS-CoV-2 vaccine, the efficacy and safety of a spike protein subunit vaccine, and neoantigen T-cell receptor gene therapy in pancreatic cancer; a review article on the uses of a GFR and albuminuria level in kidney disease; a Clinical Problem-Solving describing the after-dinner dip; and Perspective articles on navigating the loss of abortion services, on HIV prevention and the 340B Drug Pricing Program, and on the care and treatment of Black girls in America. Supplement to the New England Journal of Medicine, Vol. 386, No. 22.
June 1, 2022
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NEJM This Week — May 26, 2022

WFeaturing articles on neoadjuvant chemoimmunotherapy in resectable non–small-cell lung cancer, tranexamic acid for noncardiac surgery, activation of oncogene expression by demethylating agents, efficacy of the mRNA-1273 vaccine in older children, and structural racism in the academic residency clinic; a review article on the gliflozins in the management of cardiovascular disease; a case report of a man with fevers, night sweats, and a mediastinal mass; and Perspective articles on federal action supporting overdose-prevention centers, on when naloxone isn’t enough, and on e pluribus unum. Supplement to the New England Journal of Medicine, Vol. 386, No. 21.
May 25, 2022
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NEJM This Week — May 19, 2022

Featuring articles on childhood risk factors and adult cardiovascular events, results of two cases of pig-to-human kidney xenotransplantation, vaccine effectiveness against omicron in children and adolescents, the efficacy and safety of a BNT162b2 booster, catching up on REMs, and on NEJM Healer; a review article on brain tumors in children; a case report of a man with persistent cough and pulmonary opacities; and Perspective articles on reforming nursing home care, on progress toward pig-to-human xenotransplantation, and on being only halfway there with sudden infant death syndrome. Supplement to the New England Journal of Medicine, Vol. 386, No. 20.
May 18, 2022
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NEJM This Week — May 12, 2022

We discuss the latest in medical research and ideas.
May 11, 2022
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NEJM This Week — May 5, 2022

Featuring articles on baricitinib for alopecia areata, convalescent plasma for early SARS-CoV-2 infection, efficacy of a fourth mRNA vaccine dose in Israel, ivermectin for early Covid-19, a new image for cell sorting, and metric myopia; a review article on nonspecific low back pain; a Clinical Problem-Solving on looking back; and Perspective articles on designing Cures 2.0, on real-world evidence, and on addressing misinformation on social media. Supplement to the New England Journal of Medicine, Vol. 386, No. 18.
May 4, 2022
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NEJM This Week — April 28, 2022

Featuring articles on CT or coronary angiography in stable chest pain, protection against omicron by a fourth vaccine dose, a vaccine for RSV in pregnancy, nasal high-flow therapy during neonatal intubation, and reassessing quality assessment; a review article on understanding vaccine safety; a case report of a man with myalgias, fever, and bradycardia; and Perspective articles on the e-cigarette flavor debate and on breaking down the residency match rate. Supplement to the New England Journal of Medicine, Vol. 386, No. 17.
April 27, 2022
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NEJM This Week — April 21, 2022

Featuring articles on restricted calories and eating times in weight loss, asthma therapy in Black and Latinx adults, ivosidenib in IDH1-mutated acute myeloid leukemia, vaccine boost effects on protection against omicron, and fighting cardiac fibrosis with CAR T cells; a review article on early-onset colorectal cancer; a case report of a woman with transient ischemic attack and mitral valve masses; and Perspective articles on a change in the leading cause of death among U.S. children, on strengthening the Medicaid Reentry Act, and on Covid-19’s devastating effect on tuberculosis care. Supplement to the New England Journal of Medicine, Vol. 386, No. 16.
April 20, 2022
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NEJM This Week — April 14, 2022

Featuring articles on nirmatrelvir plus ritonavir for Covid-19, the treatment of acute Achilles’ tendon rupture, rilzabrutinib in immune thrombocytopenia, mitapivat for pyruvate kinase deficiency, and global health and the moral clarity of Paul Farmer; a review article on cancer-associated hypercalcemia; a case report of a woman with pancytopenia; and Perspective articles on fully realizing SNAP’s health benefits, on the 2022 Child Nutrition Reauthorization, and reflections on caring for the unvaccinated. Supplement to the New England Journal of Medicine, Vol. 386, No. 15.
April 13, 2022
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NEJM This Week — April 7, 2022

Featuring articles on endovascular therapy for large cerebral infarction, population immunity and Covid-19 severity with the omicron variant in South Africa, tebipenem for complicated urinary tract infection, an implanted stimulator in multiple-system atrophy, U.S. medical faculty diversity over four decades, and the origins of calcific aortic stenosis; a review article on the laboratory diagnosis of Creutzfeldt–Jakob disease; a Clinical Problem-Solving describing a burning question; and Perspective articles on ten years of Choosing Wisely to reduce low-value care, on putting health and equity at the center of the climate movement, and on the wild west of checkpoint inhibitor development. Supplement to the New England Journal of Medicine, Vol. 386, No. 14.
April 6, 2022
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NEJM This Week — March 31, 2022

Featuring articles on Covid-19 after vaccination and previous infection, vaccination after recovery from SARS-CoV-2 infection, mini-slings for stress incontinence in women, higher-dose primaquine for P. vivax malaria, and on how medicine is not gender-neutral; a review article on decompression sickness and arterial gas embolism; a case report of a man with marked ventricular wall thickening; and Perspective articles on restrictive state abortion bans, on when patients go to court for unproven treatments, and on epidemiology and the Faroe Islands. Supplement to the New England Journal of Medicine, Vol. 386, No. 13.
March 30, 2022
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NEJM This Week — March 24, 2022

Featuring articles on a single-dose liposomal amphotericin B treatment for cryptococcal meningitis, hydrocortisone to prevent bronchopulmonary dysplasia, darolutamide in metastatic prostate cancer, trastuzumab deruxtecan for HER2-positive breast cancer, addressing vaccine inequity, and targeting gene therapy to muscle; a review article on managing glycemia in children with type 1 diabetes; a case report of a woman with fever, myalgias, diarrhea, and cough; and Perspective articles on digital inclusion as health care, on a new way to contain unaffordable medication costs, and on an NPO. Supplement to the New England Journal of Medicine, Vol. 386, No. 12.
March 23, 2022
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NEJM This Week — March 17, 2022

We discuss the latest in medical research and ideas.
March 16, 2022
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NEJM This Week — March 10, 2022

Featuring articles on shorter-course TB treatment in children, thyroidectomy without radioiodine, Covid-19 vaccine effectiveness in North Carolina, ribociclib in hormone receptor–positive breast cancer, the effects of boosters after Ad26.COV2.S vaccination, and on tumors and T cells; a review article on extracorporeal kidney-replacement therapy for acute kidney injury; a case report of a woman with depression, recurrent falls, and inability to care for herself; and Perspective articles on step therapy’s balancing act, on coverage of transvenous pulmonary embolectomy, and on the catfish king. Supplement to the New England Journal of Medicine, Vol. 386, No. 10.
March 9, 2022
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NEJM This Week — March 3, 2022

Featuring articles on a balanced multielectrolyte solution versus saline in critically ill adults, troponin I after cardiac surgery and 30-day mortality, nirsevimab for prevention of RSV in infants, a final analysis of single-dose Ad26.COV2.S, and melioidosis and aromatherapy; a review article on chronic pancreatitis; a Clinical Problem-Solving on craving answers; and Perspective articles on U.S. public health law, on oral health for all, and on holding the baby. Supplement to the New England Journal of Medicine, Vol. 386, No. 9.
March 2, 2022
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NEJM This Week — February 24, 2022

Featuring articles on the effectiveness of the BNT162b2 vaccine in adolescents, the treatment of epileptiform activity after cardiac arrest, mechanisms of resistance to noncovalent BTK inhibitors, Covid-19 vaccination and delta transmission, mortality from congenital Zika syndrome in Brazil, and wound healing and stem cells; a review article on reassessing human adipose tissue; a case report of a man with fatigue, weight loss, and hyperglycemia; and Perspective articles on state restrictions on mifepristone access, on abortion training in medical education, and on stabilizing health care’s share of the GDP. Supplement to the New England Journal of Medicine, Vol. 386, No. 8.
February 23, 2022
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NEJM This Week — February 17, 2022

Featuring articles on LentiGlobin for sickle cell disease, tisagenlecleucel in aggressive B-cell lymphoma, axi-cel for relapsed or refractory large B-cell lymphoma, and EDP-938 to treat respiratory syncytial virus; a review article on electroconvulsive therapy; a case report of a woman with rapidly progressive weakness in the right arm and recurrent falls; and Perspective articles on health care safety during the pandemic and beyond, on inherited patients taking opioids for chronic pain, and on home help. Supplement to the New England Journal of Medicine, Vol. 386, No. 7.
February 16, 2022
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NEJM This Week — February 10, 2022

Featuring articles on molnupiravir for outpatient treatment of Covid-19, cemented or uncemented hemiarthroplasty for hip fracture, efficacy of the NVX-CoV2373 vaccine against Covid-19, PD-1 inhibition in relapsed cervical cancer, pembrolizumab for triple-negative breast cancer, and a pernicious cycle affecting premalignant stem cells; a review article on marginal-zone lymphomas; a case report of a man with bilateral hearing loss and eye redness; and Perspective articles on racial biology and medical misconceptions, on developing new models for health, and on roulette. Supplement to the New England Journal of Medicine, Vol. 386, No. 6.
February 9, 2022
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NEJM This Week — February 3, 2022

Featuring articles on gene therapy for β-thalassemia, mosquito nets and survival to adulthood in Tanzania, lenvatinib plus pembrolizumab for advanced endometrial cancer, and immune checkpoint therapy in esophageal cancer; a review article on fever of unknown origin; a Clinical Problem-Solving on the calm before the storm; and Perspective articles on using economics to inform public health policy, on automatic insurance policies, and on the care that was needed.Supplement to the New England Journal of Medicine, Vol. 386, No. 5.
February 2, 2022
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NEJM This Week — January 27, 2022

Featuring articles on remdesivir for prevention of Covid-19 progression, cardiovascular and cancer risk with tofacitinib, tricuspid repair in mitral-valve surgery, duration of Covid-19 vaccine protection in the U.K., polatuzumab vedotin in diffuse large B-cell lymphoma, and anti-idiotype antibodies in SARS-CoV-2; a review article on medical conditions and high-altitude travel; a case report of a boy with fever, joint pain, and abdominal cramping; and Perspective articles on universal coronavirus vaccines, on transparency and the doctor–patient relationship, and on “Please don’t keep me”. Supplement to the New England Journal of Medicine, Vol. 386, No. 4.
January 26, 2022
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NEJM This Week — January 20, 2022

Featuring articles on a randomized closed-loop trial in very young children with diabetes, microbiome therapy for C. difficile infection, secondary prophylaxis for latent rheumatic heart disease, targeting mutant HER2 in non–small-cell lung cancer, urinary sodium and potassium and cardiovascular risk, and on aesthetic distance and empathy; a review article on rapid diagnostic testing for SARS-CoV-2; a case report of a man with a recurrent left pleural effusion; and Perspective articles on research participation and diversity. Supplement to the New England Journal of Medicine, Vol. 386, No. 3.
January 19, 2022
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NEJM This Week — January 13, 2022

We discuss the latest in medical research and ideas.
January 12, 2022
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Rapid Diagnostic Testing for SARS-CoV-2 by P.K. Drain

A 38-year-old woman with type 2 diabetes has a telemedicine visit after learning that a person with whom she had close contact at an indoor wedding 3 days earlier has tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The woman reports that she is asymptomatic and received a second vaccination against SARS-CoV-2 approximately 9 months ago but has not received a booster vaccination. She attended the wedding with her husband, who has also received two vaccinations, and her two unvaccinated children, who are 5 and 8 years of age. Her husband had mild nasal congestion and a cough the evening before her appointment. She had previously purchased rapid diagnostic tests that received emergency use authorization from the Food and Drug Administration for home-based SARS-CoV-2 testing and wonders whether using these tests would be appropriate. What would you advise? Full-text recordings of Clinical Practice articles may be found at NEJM.org.
January 12, 2022
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NEJM This Week — January 6, 2022

Featuring articles on eltrombopag in severe aplastic anemia, nivolumab plus LAG-3 blockade in melanoma, the BNT162b2 vaccine against Covid-19 in 5-to-11-year-olds, azithromycin for yaws eradication, and abortion outcomes with unrestricted mifepristone; a review article on snake envenomation; a Clinical Problem-Solving on being confused about confusion; and Perspective articles on the patchwork U.S. public health system, on obstacles to physicians’ emotional health, and on the doctor’s oldest tool. Supplement to the New England Journal of Medicine, Vol. 386, No. 1.
January 5, 2022
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NEJM This Week — December 30, 2021

Featuring articles on chlorthalidone for hypertension in advanced chronic kidney disease, ticagrelor versus clopidogrel in stroke or transient ischemic attack, dolutegravir in children with HIV-1 infection, angiography after out-of-hospital cardiac arrest, and the 2021 Nobel Prize in Chemistry; a review article on the determination of brain death; a case report of a boy with transient weakness, facial droop, and slurred speech; and Perspective articles on whether we should include race or ethnicity at the beginning of clinical case presentations, on calling out aversive racism in academic medicine, on closing the gender pay gap in medicine, and on trust, faith, and Covid. Supplement to the New England Journal of Medicine, Vol. 385, No. 27.
December 29, 2021
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NEJM This Week — December 23, 2021

Featuring articles on the effects of a Covid-19 vaccine booster, spesolimab for generalized pustular psoriasis, decentralized molecular testing for tuberculosis, and consultative medicine; a review article on immune and genome engineering as the future of transplantable tissue; a case report of a woman with respiratory failure and altered mental status; and Perspective articles on clinical care and Amazon, on Covid-19 vaccination in American Indians and Alaska Natives, on tobacco-free nicotine, and on a divisive ruling on devices. Supplement to the New England Journal of Medicine, Vol. 385, No. 26.
December 22, 2021
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NEJM This Week — December 16, 2021

Featuring articles on daprodustat in patients undergoing dialysis and in those not undergoing dialysis, chemotherapy in node-positive breast cancer, a phase 3 trial of the ChAdOx1 nCoV-19 vaccine, vaccine effectiveness among U.S. health care personnel, and a hot and tactile Nobel Prize; a review article on pulmonary arterial hypertension; a case report of a woman with abdominal pain, weight loss, and memory impairment; and Perspective articles on a failure to disseminate transformative science, on E66.01 and our culture of shame, and on Ms. Omega One. Supplement to the New England Journal of Medicine, Vol. 385, No. 25.
December 15, 2021
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NEJM This Week — December 9, 2021

Featuring articles on tapinarof cream for psoriasis, dupilumab in children with asthma, the mRNA-1273 vaccine in adolescents, cardiovascular events with finerenone in kidney disease and type 2 diabetes, waning vaccine protection against SARS-CoV-2, and transgenic epidermis in junctional epidermolysis bullosa; a review article on latent tuberculosis infection; a case report of a man with fevers, fatigue, arthralgias, a mouth ulcer, and a rash; and Perspective articles on Covid-19 and the safety net and on inequitable access to hospital care. Supplement to the New England Journal of Medicine, Vol. 385, No. 24.
December 8, 2021
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NEJM This Week — December 2, 2021

Featuring articles on debulking surgery in relapsed ovarian cancer, myocarditis after Covid-19 mRNA vaccine, edoxaban for atrial fibrillation with TAVR, milvexian for the prevention of venous thromboembolism, REGEN-COV in outpatients with acute SARS-CoV-2 infection, and a font of protein structures; a review article on spontaneous intracranial hypotension; a Clinical Problem-Solving describing a “fluid” diagnosis; and Perspective articles on using policy tools to improve population health, on decarbonizing the U.S. health sector, and on the web we weave. Supplement to the New England Journal of Medicine, Vol. 385, No. 23.
December 1, 2021
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NEJM This Week — November 25, 2021

Featuring articles on spinal or general anesthesia for hip surgery, HIF-2α inhibition in von Hippel–Lindau disease, live birth after genetic testing for aneuploidy, belzutifan in the Pacak–Zhuang syndrome, and on responsible innovation in reproductive medicine; a review article on osteosarcoma; a case report of a man with pain and erythema of the left hand; and Perspective articles on why aducanumab is priced at $56,000 per patient, on Medicare coverage of aducanumab, and on the little things. Supplement to the New England Journal of Medicine, Vol. 385, No. 22.
November 24, 2021
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NEJM This Week — November 18, 2021

Featuring articles on hematopoietic gene therapy for Hurler syndrome, sotrovimab for early Covid-19, convalescent plasma for high-risk Covid-19, gene therapy for hemophilia A, parathyroid hormone resistance, and on hunger and mood; a review article on salt handling and blood pressure; a case report of a woman with pain in the left upper quadrant and hypoxemia; and Perspective articles on regulating drug prices while increasing innovation and on the drug-pricing debate redux. Supplement to the New England Journal of Medicine, Vol. 385, No. 21.
November 17, 2021
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NEJM This Week — November 11, 2021

Featuring articles on alteplase followed by endovascular treatment for stroke, sacubitril–valsartan in acute myocardial infarction, pembrolizumab in advanced cervical cancer, genome sequencing in health care, and screening for cervical cancer; a review article on pollution and the heart; a case report of a man with altered mental status and new onset of seizures; and Perspective articles on the future of SARS-CoV-2 vaccination and on when women and children made the policy agenda. Supplement to the New England Journal of Medicine, Vol. 385, No. 20.
November 10, 2021
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NEJM This Week — November 4, 2021

Featuring articles on new equations for estimating GFR without race, BNT162b2 vaccine at 6 months of follow-up, efficacy of the mRNA-1273 vaccine at the end of the blinded phase, providing grist for antitumor immunity; and continuity, fragmentation, and Adam Smith; a review article on peritoneal dialysis; a Clinical Problem-Solving describing a copycat; and Perspective articles on applying a subpopulation lens to population health, on racial and ethnic diversity at medical schools, and on none of the above. Supplement to the New England Journal of Medicine, Vol. 385, No. 19.
November 3, 2021
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NEJM This Week — October 28, 2021

Featuring articles on dual antiplatelet therapy in patients at high bleeding risk, itepekimab in moderate-to-severe asthma, risankizumab in severe asthma, and vaccine-induced thrombocytopenia and thrombosis; a review article on abdominal aortic aneurysms; a case report of a man with painful mouth ulcers; and Perspective articles on uncomfortable truths, on the 2021 reauthorization of the Child Abuse Prevention and Treatment Act, and on a therapeutic relationship. Supplement to the New England Journal of Medicine, Vol. 385, No. 18.
October 27, 2021
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NEJM This Week — October 21, 2021

Featuring articles on a randomized trial of a pan-PPAR agonist in NASH, outcomes in nonalcoholic fatty liver disease, the AQP1 promoter variant and peritoneal dialysis, obesity in childhood and GNAS mutations, and optogenetics recognized through the Lasker Award; a review article on point-of-care ultrasonography; a case report of a girl with swelling of the jaw and hypercalcemia; and Perspective articles on blood donation by gay and bisexual men, on the case for wage equity for essential health care workers, and on peak moments. Supplement to the New England Journal of Medicine, Vol. 385, No. 17.
October 20, 2021
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NEJM This Week — October 14, 2021

Featuring articles on empagliflozin in heart failure with preserved ejection fraction, oxytocin in autism spectrum disorder, breakthrough Covid-19 in health care workers, a cell-culture influenza vaccine, and data in crisis; a review article on aspergillus infections; a case report of a man with sore throat, epistaxis, and oropharyngeal petechiae; and Perspective articles on vigilante injustice, eviction and the necessary conditions for health, the drug-dosing conundrum in oncology, and on a good death. Supplement to the New England Journal of Medicine, Vol. 385, No. 16.
October 13, 2021
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NEJM This Week — October 7, 2021

Featuring articles on Covid-19 vaccine effectiveness in medical settings, immediate vs. delayed drainage for infected necrotizing pancreatitis, bamlanivimab plus etesevimab for Covid-19, third dose of Covid-19 vaccine in Israel, broadly neutralizing antibodies against all coronaviruses, striving for diversity in research studies, and mRNA vaccine research and the Lasker–DeBakey Award; a review article on autoimmune hemolytic anemias; a Clinical Problem-Solving on a woman with throat pain; and Perspective articles on methods of public health research, on the No Surprises Act and informed financial consent, and on integrating research into community practice. Supplement to the New England Journal of Medicine, Vol. 385, No. 15.
October 6, 2021
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NEJM This Week — September 30, 2021

Featuring articles on antidepressants in primary care practice, intensive blood-pressure control in older patients, ozanimod for ulcerative colitis, and Wnt proteins and structural birth defects; a review article on newer biologic and small-molecule therapies for IBD; a case report of a man with recurrent head and neck pain; and Perspective articles on moving toward a new era for the Indian Health System, on marking the 40th anniversary of the AIDS epidemic, and on cool water. Supplement to the New England Journal of Medicine, Vol. 385, No. 14.
September 29, 2021
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NEJM This Week — September 23, 2021

Featuring articles on artemisinin-resistant malaria in Africa, safety and efficacy of the NVX-CoV2373 vaccine, subcutaneous antibody combination and Covid-19, tebentafusp for uveal melanoma, reenergizing HCV vaccine development, and HER2-mutated breast cancer and overcoming drug resistance; a review article on mesothelioma; a case report of a boy with fever and developmental regression; and Perspective articles on public health law after Covid-19 and on revitalizing the U.S. primary care infrastructure. Supplement to the New England Journal of Medicine, Vol. 385, No. 13.
September 22, 2021
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NEJM This Week — September 16, 2021

Featuring articles on salt substitution and cardiovascular events, safety of the BNT162b2 mRNA Covid-19 vaccine, lutetium-177 in prostate cancer, typhoid vaccine in Malawian children, and a call for emergency action on the climate crisis; a review article on the treatment of acute appendicitis; a case report of a woman with Covid-19 and suicidal ideation; and Perspective articles on public option plans and on the treatment of older adults with cancer. Supplement to the New England Journal of Medicine, Vol. 385, No. 12.
September 15, 2021
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NEJM This Week — September 9, 2021

Featuring articles on a trial of mobile stroke units, iron interventions in infants in rural Bangladesh, somatic mutations in sporadic cerebral cavernous malformations, malaria vaccination with or without chemoprevention, and sensible but very cool advances in protein chemistry; a review article on the challenges of sarcoidosis and its management; a case report of an adolescent seeking HIV prophylaxis; and Perspective articles on SARS-CoV-2 human challenge studies, on supporting value-based health care, and on environmental racism and climate change. Supplement to the New England Journal of Medicine, Vol. 385, No. 11.
September 8, 2021
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NEJM This Week — September 2, 2021

Featuring articles on the inactivated SARS-CoV-2 vaccine in Chile, mycophenolate mofetil for immune thrombocytopenia, cardiovascular and renal outcomes with efpeglenatide, MRI-directed prostate biopsies, and natural killer cells in defense against HPV; a review article on chronic meningitis; a Clinical Problem-Solving describing inadequate support; and Perspective articles on population health and human rights, on Covid-induced changes in health care delivery, and on paying for digital health care. Supplement to the New England Journal of Medicine, Vol. 385, No. 10.
September 1, 2021
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NEJM This Week — August 26, 2021

Featuring articles on therapeutic anticoagulation in hospitalized patients with Covid-19, anticoagulation in moderate Covid-19, a monoclonal antibody for malaria prevention, triple therapy for cystic fibrosis, modeling heart development, and remembering past lessons about structural racism; a review article on heparin resistance; a case report of a man with relapsed acute myeloid leukemia; and Perspective articles on revisiting the FDA approval of aducanumab, on controversy and progress in Alzheimer’s disease, and on a pink salwar. Supplement to the New England Journal of Medicine, Vol. 385, No. 9.
August 25, 2021
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NEJM This Week — August 19, 2021

Featuring articles on adjuvant pembrolizumab in renal-cell carcinoma, oral atogepant for migraine prevention, male infertility and small noncoding RNAs, and adjunct immune globulin for vaccine-induced thrombotic thrombocytopenia; a review article on long-term survival after kidney transplantation; a case report of a man with fatigue and leg swelling; and Perspective articles on ending the campaign to undo the ACA in the courts, on Medicare Physician Payment Reform, and on the Covid-19 infodemic. Supplement to the New England Journal of Medicine, Vol. 385, No. 8.
August 18, 2021
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NEJM This Week — August 12, 2021

Featuring articles on vaccine effectiveness against the delta Covid-19 variant, injectable cabotegravir for prevention of HIV infection, antibody to factor XI after total knee replacement, year 1 of the Bundled Payments for Care Improvement–Advanced payment model, and on a new dimension in the RNA world; a review article on signature cytokines and immune-mediated inflammatory diseases; a case report of a woman with fever, sore throat, and confusion; and Perspective articles on confronting long-haul Covid, on the criminalization of gender-affirming care, and on when low tech wins. Supplement to the New England Journal of Medicine, Vol. 385, No. 7.
August 11, 2021
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NEJM This Week — August 5, 2021

Featuring articles on CRISPR-Cas9 disruption of TTR in transthyretin amyloidosis, tirzepatide versus semaglutide for type 2 diabetes, milrinone or dobutamine for cardiogenic shock, decompression versus fusion for lumbar spondylolisthesis, and SARS-CoV-2 and immunosuppression; a review article on age-related macular degeneration; a Clinical Problem-Solving on turning purple with pain; and Perspective articles on the complementarity of public health and medicine, on contact tracing for Covid-19, on supporting trainees from groups that are underrepresented in medicine, and on establishing medical civil rights. Supplement to the New England Journal of Medicine, Vol. 385, No. 6.
August 4, 2021
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NEJM This Week — July 29, 2021

Featuring articles on the duration of adjuvant therapy in breast cancer, tofacitinib for Covid-19 pneumonia, complications in youth-onset type 2 diabetes, a small-molecule SMN2 modifier in type 1 spinal muscular atrophy, a hyperimmune globulin to prevent congenital cytomegalovirus, and scarless wound healing; a review article on depression in adolescents; a case report of a woman with bloody stools and thrombocytopenia; and Perspective articles on from crime to care, on health care budgets for rural providers, on identifying and tracking SARS-CoV-2 variants, and on a child’s loss. Supplement to the New England Journal of Medicine, Vol. 385, No. 5.
July 28, 2021
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NEJM This Week — July 22, 2021

Featuring articles on PCI guided by FFR or angiography for STEMI, pimavanserin for dementia-associated psychosis, Covid-19 prevention and attenuation with mRNA vaccines, second-line treatment of HIV-1 infection in Sub-Saharan Africa, and racial inequality in prescription opioid receipt; a review article on substance use among men who have sex with men; a case report of a woman with cognitive impairment, headache, and memory loss; and Perspective articles on medical–financial partnerships, on Virchow at 200 and Lown at 100, and on one hundred years of insulin for some. Supplement to the New England Journal of Medicine, Vol. 385, No. 4.
July 21, 2021
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NEJM This Week — July 15, 2021

Featuring articles on rehabilitation after hospitalization for heart failure, detecting speech in a paralyzed person with anarthria, ruxolitinib for chronic graft-versus-host disease, BNT162b2 vaccination against Covid-19 in 12-to-15-year-old adolescents, and inhibiting PD-L1 in hepatocellular carcinoma; a review article on the initial management of seizure in adults; a case report of a pregnant woman with fever, abdominal pain, and headache; and Perspective articles on averting future vaccine inequity, on scaling up Covid-19 vaccination in Africa, and on a medical home. Supplement to the New England Journal of Medicine, Vol. 385, No. 3.
July 14, 2021
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NEJM This Week — July 8, 2021

Featuring articles on fetal surgery for severe left diaphragmatic hernia and for moderate left diaphragmatic hernia, comparisons of interleukin-17 inhibitors in psoriasis, and SARS-CoV-2 variants and vaccines; a review article on hematuria in adults; a case report of a man with ataxia; and Perspective articles on addressing vaccine hesitancy in BIPOC communities, on Covid-19 vaccine follow-through, and on the CT scan after 50 years. Supplement to the New England Journal of Medicine, Vol. 385, No. 2.
July 7, 2021
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NEJM This Week — July 1, 2021

Featuring articles on the treatment of multisystem inflammatory syndrome in children, a transglutaminase 2 inhibitor for celiac disease, daratumumab in light-chain amyloidosis, embryo selection in vitro, and clonal peregrinations in the placenta; a review article on cerebral venous thrombosis; a Clinical Problem-Solving on a brewing back pain; and Perspective articles on the learning health system, on whether learning is worth the trouble, and on Covid-19 and the investigator pipeline. Supplement to the New England Journal of Medicine, Vol. 385, No. 1.
June 30, 2021
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NEJM This Week — June 24, 2021

We discuss the latest in medical research and ideas.
June 23, 2021
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NEJM This Week — June 17, 2021

Featuring articles on mRNA Covid-19 vaccine safety in pregnant persons, hypothermia or normothermia after cardiac arrest, rituximab vs. mycophenolate mofetil for pemphigus, sudden cardiac death in persons with HIV, and SARS-CoV-2 vaccine design; a review article on infections in patients with cirrhosis; a case report of a man with cough, fever, and shortness of breath; and Perspective articles on promoting equity for women in medicine, on misogyny in medicine, and on escaping the labyrinth. Supplement to the New England Journal of Medicine, Vol. 384, No. 24.
June 16, 2021
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NEJM This Week — June 10, 2021

Featuring articles on wolbachia-infected mosquito deployments for dengue, Ad26.COV2.S vaccine efficacy against Covid-19, thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination, variant SARS-CoV-2 infection after vaccination, and on diabetes treatment and control in U.S. adults from 1999 to 2018; a review article on recent advances in the treatment of melanoma; a case report of a woman with pain, swelling, and ecchymosis of the left arm; and Perspective articles on HIPAA at 25, on HIPAA and the leak of “deidentified” EHR data, and on what did I sign up for? Supplement to the New England Journal of Medicine, Vol. 384, No. 23.
June 9, 2021
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NEJM This Week — June 3, 2021

Featuring articles on left atrial appendage occlusion during cardiac surgery, thrombosis after ChAdOx1 nCoV-19 vaccination, adjuvant nivolumab for invasive urothelial carcinoma, a meningococcal X vaccine in Mali, and irritable bowel syndrome and immunity; a review article on HIV infection; a Clinical Problem-Solving describing a hypertensive heartbreak; and Perspective articles on women’s health; on institutional problems, individual solutions; and on merging mortalities. Supplement to the New England Journal of Medicine, Vol. 384, No. 22.
June 2, 2021
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NEJM This Week — May 27, 2021

Featuring articles on aspirin dosing in cardiovascular disease, antibiotic therapy for prosthetic joint infection, gene therapy for adenosine deaminase deficiency, a novel microRNA in acute myocarditis, and immediate “kangaroo mother care” of low-birth-weight infants; a review article on somatic mutations in “benign” disease; a case report of a woman with abdominal pain and aortic dilatation; and Perspective articles on the “legal epidemiology” of pandemic control, on a hidden opportunity, and on dilemmas of double consciousness. Supplement to the New England Journal of Medicine, Vol. 384, No. 21.
May 26, 2021
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NEJM This Week — May 20, 2021

Featuring articles on efficacy of the ChAdOx1 nCoV-19 vaccine against the B.1.351 variant, NVX-CoV2373 vaccine efficacy against B.1.351 in South Africa, endovascular therapy for basilar-artery stroke, intensive or standard blood-pressure control, and on gene editing for congenital neutropenia; a review article on monoclonal gammopathy of renal significance; a case report of a woman with nausea, diarrhea, and acute kidney failure; and Perspective articles on minority tax reform, on training future health justice leaders, and on finding a way to break through the fog. Supplement to the New England Journal of Medicine, Vol. 384, No. 20.
May 19, 2021
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NEJM This Week — May 13, 2021

We discuss the latest in medical research and ideas.
May 12, 2021
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NEJM This Week — May 6, 2021

Featuring articles on a trial of an antibody to amyloid in Alzheimer’s disease, short-course treatment of tuberculosis, weight loss maintenance with exercise and liraglutide, dexamethasone and surgical-site infection, a fountain of youthful retinal ganglion cells, and decoupling crisis response from policing; a review article on gastric emptying abnormalities in diabetes; a Clinical Problem-Solving on the inside and out; and Perspective articles on understanding and mitigating health inequities, on designing an independent public health agency, and on losing touch. Supplement to the New England Journal of Medicine, Vol. 384, No. 18.
May 5, 2021
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NEJM This Week — April 29, 2021

Featuring articles on vadadustat in non–dialysis-dependent chronic kidney disease, vadadustat for anemia in patients undergoing dialysis, oncolytic HSV therapy in pediatric glioma, blood-loss prevention after cesarean delivery, and diversity of the national medical student body; a review article on postpartum hemorrhage; a case report of a newborn girl with a neck mass; and Perspective articles on Australian firearm regulation at 25, on vaccination plus decarceration, and on the Zoom family meeting. Supplement to the New England Journal of Medicine, Vol. 384, No. 17.
April 28, 2021
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NEJM This Week — April 22, 2021

Featuring articles on interleukin-6 receptor blockade in severe Covid-19, tocilizumab in severe Covid-19 pneumonia, a microbiota-directed food supplement for malnutrition, sacituzumab govitecan in triple-negative breast cancer, and fighting SARS-CoV-2 with nanobodies; a review article on adrenal incidentaloma; a case report of a man with a rash on the scalp and face; and Perspective articles on advancing President Biden’s equity agenda, on encouraging acceptance of Covid-19 vaccines, and on Nanima. Supplement to the New England Journal of Medicine, Vol. 384, No. 16.
April 21, 2021
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NEJM This Week — April 15, 2021

Featuring articles on hypothermic machine perfusion in liver transplantation, a trial of psilocybin for depression, the effectiveness of the BNT162b2 mRNA vaccine in Israel, sedation in mechanically ventilated adults with sepsis, and soothing science skepticism; a review article on glomerular filtration and albuminuria; a case report of a woman with fever, flank pain, and inguinal lymphadenopathy; and Perspective articles on new legislation on out-of-network billing, on remote patient monitoring, and on remembering the Freedom House Ambulance Service. Supplement to the New England Journal of Medicine, Vol. 384, No. 15.
April 14, 2021
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NEJM This Week — April 8, 2021

Featuring articles on lenvatinib plus pembrolizumab in renal cell cancer, oxygenation targets for acute respiratory failure, cardiovascular risk and glycemic index, sutimlimab in cold agglutinin disease, extending life span in a mouse model of progeria, and overcoming Covid vaccine hesitancy; a review article on vestibular schwannomas; a case report of a man with depressed mood, unsteady gait, and urinary incontinence; and Perspective articles on combatting vaccine nationalism, on vancomycin infusion reaction, and on minds in crisis in a city in crisis. Supplement to the New England Journal of Medicine, Vol. 384, No. 14.
April 7, 2021
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NEJM This Week — April 1, 2021

Featuring articles on adjuvant nivolumab in esophageal cancer, sotatercept for pulmonary arterial hypertension, lumasiran for primary hyperoxaluria type 1, upadacitinib for psoriatic arthritis, and an Ebola relapse leading to transmission; a review article on glucose-lowering drugs to prevent cardiovascular disease; a Clinical Problem-Solving on stalking the diagnosis; and Perspective articles on emerging infectious diseases, on ensuring that LGBTQI+ people count, and on the first Black woman to earn a medical degree in the United States. Supplement to the New England Journal of Medicine, Vol. 384, No. 13.
March 31, 2021
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NEJM This Week — March 25, 2021

Featuring articles on the efficacy of the ALVAC–gp120 HIV vaccine, a JAK inhibitor or interleukin-4 blockade for atopic dermatitis, semaglutide for nonalcoholic steatohepatitis, enfortumab vedotin for relapse of urothelial cancer, the link between cancer and obesity, and embracing genetic diversity to improve Black health; a review article on atopic dermatitis; a case report of a boy with headache, abdominal pain, and hypertension; and Perspective articles on progress in vaccine technology, on addressing workforce diversity, and on the good fit. Supplement to the New England Journal of Medicine, Vol. 384, No. 12.
March 24, 2021
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NEJM This Week — March 18, 2021

Featuring articles on once-weekly semaglutide in adults with overweight or obesity, neutralizing antibodies to prevent HIV-1 infection, passive immunotherapy in patients with Covid-19, inhibition of C3 in paroxysmal nocturnal hemoglobinuria, and the political nature of sex; a review article on extrahepatic manifestations of chronic HCV infection; a case report of a woman with cholangiocarcinoma; and Perspective articles on private equity and physician medical practices, on the good doctor, and on the intern. Supplement to the New England Journal of Medicine, Vol. 384, No. 11.
March 17, 2021
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NEJM This Week — March 11, 2021

Featuring articles on a randomized trial of gestational diabetes screening, a neutralizing monoclonal antibody for hospitalized patients with Covid-19, risdiplam in type 1 spinal muscular atrophy, genome sequencing in myeloid cancers, a cautionary note about round spermatid injection, and supplying insulin while evading immunity; a review article on epistaxis; a case report of a man with shock, multiple organ failure, and rash; and Perspective articles on supporting clinical trainees with disabilities, on doctors with mental illness and structural barriers to disclosure, and on being breathless. Supplement to the New England Journal of Medicine, Vol. 384, No. 10.
March 10, 2021
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NEJM This Week — March 4, 2021

Featuring articles on baricitinib plus remdesivir for adults with Covid-19, albumin infusions in patients with cirrhosis, a trial of terlipressin for hepatorenal syndrome, nivolumab plus cabozantinib in renal-cell carcinoma, and on misrepresenting race; a review article on diffuse large B-cell lymphoma; a Clinical Problem-Solving describing a treacherous course; and Perspective articles on conquering atherosclerotic cardiovascular disease, on reform of payment for primary care, and on being without sanctuary. Supplement to the New England Journal of Medicine, Vol. 384, No. 9.
March 3, 2021
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NEJM This Week — February 25, 2021

Featuring articles on dexamethasone treatment in Covid-19, BCMA-specific CAR T cells in refractory myeloma, a cholinergic agonist and peripheral antagonist for schizophrenia, the Center for Medicare and Medicaid Innovation at 10 years, inflammation in ALS, and how structural racism works; a review article on β-thalassemias; a case report of a man with eye pain and decreased vision; and Perspective articles on last-mile logistics of Covid-19 vaccination, on telemedicine and medical licensure, and on the inequity of isolation. Supplement to the New England Journal of Medicine, Vol. 384, No. 8.
February 24, 2021
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NEJM This Week — February 18, 2021

Featuring articles on a C5a receptor inhibitor for ANCA vasculitis, convalescent plasma in Covid-19, relugolix combination therapy for uterine fibroid symptoms, and promoting Covid-19 vaccination in the United States; a review article on maintaining safety with SARS-CoV-2 vaccines; a case report of a man with delirium and renal insufficiency; and Perspective articles on vaccinating children against Covid-19 and on the FDA’s experience with Covid-19 antibody tests. Supplement to the New England Journal of Medicine, Vol. 384, No. 7.
February 17, 2021
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NEJM This Week — February 11, 2021

Featuring articles on repurposed antiviral drugs for Covid-19, a tirbanibulin ointment for actinic keratosis, a vestibular implant for bilateral vestibular hypofunction, antibodies and SARS-CoV-2 infection in health workers, a randomized trial of an HCV vaccine regimen, and regulatory T cells in multiple sclerosis; a review article on circadian mechanisms in medicine; a case report of a woman with dyspnea on exertion and abnormal findings on chest imaging; and Perspective articles on the future of drug-pricing transparency, on a shared evaluation platform for medical training, and on lessons from the Irish wake. Supplement to the New England Journal of Medicine, Vol. 384, No. 6.
February 10, 2021
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NEJM This Week — February 4, 2021

Featuring articles on an mRNA-1273 vaccine to prevent Covid-19, a trial of hydroxychloroquine to prevent Covid-19, breast cancer risk revisited, much ado about certain breast cancer genes, and race and genetic ancestry in medicine; a review article on antithrombotic therapy after acute coronary syndromes; a Clinical Problem-Solving describing the hunt for a diagnosis; and Perspective articles on vaccine innovations, on the search of a better equation, and on learning about end-of-life care from Grandpa. Supplement to the New England Journal of Medicine, Vol. 384, No. 5.
February 3, 2021
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NEJM This Week — January 28, 2021

Featuring articles on cryoablation for atrial fibrillation, inhaled treprostinil in interstitial lung disease, a levonorgestrel vs. copper IUD for emergency contraception, the return of cardiac activity after withdrawal of life support, and antigen presentation by B cells in multiple sclerosis; a review article on atrial fibrillation; a case report of a man with transient vision loss; and Perspective articles on reimagining infective endocarditis care amid the opioid epidemic, on a medical “ecology of attention”, and on the surgeon and the mother. Supplement to the New England Journal of Medicine, Vol. 384, No. 4.
January 27, 2021
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NEJM This Week — January 21, 2021

Featuring articles on inhibiting BCL11A to treat sickle cell disease and β-thalassemia, a polypill with or without aspirin in primary prevention, and neutralizing-antibody therapy in Covid-19; a review article on the effects of infection on natural immunity; a case report of a pregnant woman with ventricular tachycardia and shock; and Perspective articles on testing in a pandemic, on the Supreme Court and pandemic controls, and on incarceration and social death. Supplement to the New England Journal of Medicine, Vol. 384, No. 3.
January 20, 2021
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NEJM This Week — January 14, 2021

Featuring articles on omecamtiv mecarbil in systolic heart failure, sotagliflozin in diabetes with heart failure, sotagliflozin for heart failure in diabetes and kidney disease, bupropion and naltrexone for methamphetamine use, and procuring oligodendrocytes after spinal cord injury; a review article on Ewing’s sarcoma; a case report of a woman with lethargy and altered mental status; and Perspective articles on the Purdue Pharma opioid settlement, on drug-coated devices for peripheral arterial disease, and on the doctor as street-level bureaucrat. Supplement to the New England Journal of Medicine, Vol. 384, No. 2.
January 13, 2021
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NEJM This Week — January 7, 2021

Featuring articles on sitagliptin for prevention of acute GVHD, tocilizumab in Covid-19 pneumonia, rilonacept in recurrent pericarditis, vaginal mother-to-child transmission of cancer, and on whether the melanoma epidemic is real; a review article on osteoarthritis of the knee; a Clinical Problem-Solving on breathing for two; and Perspective articles on human molecular genetics and genomics, on Covid-19 and the undocumented Latinx community, and on the stress of Bayesian medicine. Supplement to the New England Journal of Medicine, Vol. 384, No. 1.
January 6, 2021
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NEJM This Week — December 31, 2020

Featuring articles on the safety and efficacy of an RNA-based SARS-CoV-2 vaccine, dexamethasone in chronic subdural hematoma, sleuthing out a severe adult inflammatory disorder, hemoglobin transfusion thresholds in infants, and vaccinating against SARS-CoV-2; a review article on the pathophysiology of inflammatory bowel diseases; a case report of a man with memory loss and odd behavior; and Perspective articles on reimagining how policymakers identify safety-net hospitals, on Medicaid and child health equity, on the FDA approval of remdesivir, and on whiteouts. Supplement to the New England Journal of Medicine, Vol. 383, No. 27.
December 30, 2020
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NEJM This Week — December 24, 2020

Featuring articles on ultrasound subthalamotomy for Parkinson’s disease, antenatal dexamethasone for early preterm birth, oral azacitidine maintenance therapy for AML, paclitaxel-coated devices in peripheral artery disease, and seizure frequency during pregnancy; a review article on estrogen receptor–positive breast cancer; a case report of a man with headache and Covid-19; and Perspective articles on the gift; on new order, new hope; on resilience in the face of Covid-19; and on holding up. Supplement to the New England Journal of Medicine, Vol. 383, No. 26.
December 23, 2020
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NEJM This Week — December 17, 2020

Featuring articles on SARS-CoV-2 transmission among Marine recruits, SARS-CoV-2 transmission on an aircraft carrier, an mRNA vaccine against Covid-19 in older adults, a phase 1 trial of an RNA-based Covid-19 vaccine, and the cardiomyocyte and the mighty mitochondrion; a review article on severe Covid-19; a case report of a boy with seizure and hypocalcemia; and Perspective articles on health coverage and care for transgender people, on rethinking sex designations on birth certificates, on being interviewed while Black, and on the caregiver. Supplement to the New England Journal of Medicine, Vol. 383, No. 25.
December 16, 2020
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NEJM This Week — December 10, 2020

Featuring articles on lipid lowering through activation of lipoprotein lipase, on a SARS-CoV-2 recombinant nanoparticle vaccine, on tocilizumab in Covid-19, and on survival with olaparib in prostate cancer; a review article on spontaneous coronary-artery dissection; a case report of a man with cancer and acute hypoxemia; and Perspective articles on the discovery of hepatitis C, on how Medicare Part D has failed to deliver savings to older adults, on a pandemic within a pandemic, and on Telephone. Supplement to the New England Journal of Medicine, Vol. 383, No. 24.
December 9, 2020
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NEJM This Week — December 3, 2020

Featuring articles on pembrolizumab in microsatellite-unstable colorectal cancer, the effect of finerenone on chronic kidney disease outcomes, person-to-person spread of Andes virus, malaria chemoprophylaxis in sub-saharan Africa, and epigenetic regulation in prostate cancer; a review article on cytokine storm; a Clinical Problem-Solving on looking for the outsider; and Perspective articles on solving population-wide obesity, on the bottom of the health care rationing iceberg, on understanding questions and answers about Covid-19 vaccination, and on why we need black physicians in academic medicine. Supplement to the New England Journal of Medicine, Vol. 383, No. 23.
December 2, 2020
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NEJM This Week — November 26, 2020

We discuss the latest in medical research and ideas.
November 25, 2020
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NEJM This Week — November 19, 2020

Featuring articles on golimumab and beta-cell function in type 1 diabetes, lorlatinib in ALK-positive lung cancer, hydroxychloroquine in patients with Covid-19, hydroxychloroquine with or without azithromycin in Covid-19, crafty killing of pathogenic microbes in the placenta, and physician–public defender collaboration; a review article on endometrial cancer; a case report of a woman with dark urine and weakness; and Perspective articles on the regulation of over-the-counter hearing aids, on transgender women on college athletic teams, and on unclaimed bodies in the anatomy lab. Supplement to the New England Journal of Medicine, Vol. 383, No. 21.
November 18, 2020
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NEJM This Week — November 12, 2020

We discuss the latest in medical research and ideas.
November 11, 2020
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NEJM This Week — November 5, 2020

We discuss the latest in medical research and ideas.
November 4, 2020
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NEJM This Week — October 29, 2020

Featuring articles on osimertinib adjuvant therapy in EGFR-mutated non–small-cell lung cancer, a durable humoral response to SARS-CoV-2, low-dose edoxaban in atrial fibrillation, and exome sequencing for nonimmune hydrops fetalis; a review article on mild or moderate Covid-19; a case report of a man with chronic kidney disease; and Perspective articles on Operation Warp Speed’s strategy and approach, on evaluating and deploying Covid-19 vaccines, on pharmaceutical industry caution vs. federal acceleration of Covid-19 vaccine approval, and on the new stability. Supplement to the New England Journal of Medicine, Vol. 383, No. 18.
October 28, 2020
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NEJM This Week — October 22, 2020

Featuring articles on dasatinib–blinatumomab in Ph-positive ALL, an anti–Siglec-8 antibody in gastritis and duodenitis, inhaled molgramostim therapy in autoimmune pulmonary alveolar proteinosis, treating Middle East Respiratory Syndrome, fibroblasts in rheumatoid arthritis, and how can we bridge the partisan divide and conquer Covid; a review article on sensory ganglionopathy; a case report of a man with abdominal pain, joint swelling, and skin lesions; and Perspective articles on whether the elections can end the health reform stalemate, on insurance coverage after job loss, on redoubling efforts to help Americans quit smoking, and on taking back our voices. Supplement to the New England Journal of Medicine, Vol. 383, No. 17.
October 21, 2020
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NEJM This Week — October 15, 2020

Featuring articles on upadacitinib or abatacept in rheumatoid arthritis, a nimble GWAS on Covid-19, life expectancy after bariatric surgery, an mRNA–based Covid-19 vaccine in nonhuman primates, and selection against pathogenic mitochondrial DNA; a review article on autophagy in human diseases; a case report of a man with confusion, fatigue, and garbled speech; and Perspective articles on health policy in a Biden administration or after a Trump election victory, on Covid-19 and the mandate to redefine preventive care, and on when all you have is quality of life. Supplement to the New England Journal of Medicine, Vol. 383, No. 16.
October 14, 2020
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NEJM This Week — October 8, 2020

Featuring articles on empagliflozin in heart failure, cardiovascular outcomes with ertugliflozin in diabetes, dapagliflozin in chronic kidney disease, single or dual antiplatelet treatment after TAVI, on dying in a leadership vacuum, Covid-19 and implications for the health care system, and mending mitochondrial mutation; a review article on secondary mitral regurgitation; a case report of a man with lymphoma and abdominal pain; and Perspective articles on the role of market forces in U.S. health care, on embracing antiracism in medicine, and on improving clinical trial enrollment. Supplement to the New England Journal of Medicine, Vol. 383, No. 15.
October 7, 2020
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NEJM This Week — October 1, 2020

Featuring articles on early rhythm-control therapy for atrial fibrillation, evolocumab in heterozygous pediatric familial hypercholesterolemia, atezolizumab in non–small-cell lung cancer, HPV vaccination and the risk of cervical cancer, and physician work hours and the gender pay gap; a review article on myelodysplastic syndromes; a Clinical Problem-Solving describing parroting lymphoma; and Perspective articles on health in aging, on ensuring uptake of vaccines against SARS-CoV-2, on an innovative approach to reducing gun suicides, and on the ritual of the table. Supplement to the New England Journal of Medicine, Vol. 383, No. 14.
September 30, 2020
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NEJM This Week — September 24, 2020

Featuring articles on a RAS oncogene inhibitor at last, avelumab maintenance therapy in bladder cancer, lower-dose zinc for childhood diarrhea, antisense oligonucleotides for hereditary angioedema, and sussing out the sestrins; a review article on congenital adrenal hyperplasia due to 21-hydroxylase deficiency; a case report of a man with sudden cardiac arrest; and Perspective articles on competing visions for the future of health policy, on assessing the safety of glucose-lowering drugs, on Ebola response priorities in the time of Covid-19, and on a farewell gift from a mother. Supplement to the New England Journal of Medicine, Vol. 383, No. 13.
September 23, 2020
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NEJM This Week — September 17, 2020

Featuring articles on exome sequencing analysis in stillbirth, a two-year trial of belimumab in lupus nephritis, nocturnal oxygen in COPD, adjuvant targeted therapy in melanoma, and daratumumab in refractory lupus; a review article on immune tolerance; a case report of a man with fever and shortness of breath after liver transplantation; and Perspective articles on consent to trainee involvement in pediatric care, on examining examinations conducted under anesthesia, on June Medical Services v. Russo, and on sticks and stones. Supplement to the New England Journal of Medicine, Vol. 383, No. 12.
September 16, 2020
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NEJM This Week — September 10, 2020

Featuring articles on strategies for tracheostomy decannulation, extending factor VIII activity in hemophilia A, eflornithine–sulindac in familial adenomatous polyposis, darolutamide in castration-resistant prostate cancer, the NIH RADx initiative, and on training innate immunity; a review article on pharmacologic treatment of ADHD; a case report of a man with intrusive thoughts and fear of poisoning; and Perspective articles on health equity, on the cancer risk associated with lorcaserin, on whether Covid can catalyze an educational transformation, and on the ideal intern. Supplement to the New England Journal of Medicine, Vol. 383, No. 11.
September 9, 2020
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NEJM This Week — September 3, 2020

Featuring articles on weight loss in underserved patients, the effect of phenylbutyrate–taurursodiol on ALS progression, tepotinib in lung cancer, capmatinib in MET-altered lung cancer, and reopening primary schools during the pandemic; a review article on pulmonary fibrotic diseases; a Clinical Problem-Solving describing a curve ball; and Perspective articles on progress in cancer research, prevention, and care; on public health decision making during Covid-19; on long-term care policy after Covid-19; and on the tragedy of measles. Supplement to the New England Journal of Medicine, Vol. 383, No. 10.
September 2, 2020
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NEJM This Week — August 27, 2020

Featuring articles on selpercatinib in RET fusion–positive lung cancer, selpercatinib for medullary thyroid cancer, a closed-loop system in children with type 1 diabetes, sticky findings in breast cancer, and reconsidering the use of race correction in clinical algorithms; a review article on atherosclerotic plaque healing; a case report of a woman with headache and gait imbalance; and Perspective articles on improving the quality of U.S. health care, on Covid-19 and immunity in aging populations, and on U.S. efforts to curb antibiotic resistance. Supplement to the New England Journal of Medicine, Vol. 383, No. 9.
August 26, 2020
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NEJM This Week — August 20, 2020

Featuring articles on evinacumab for familial hypercholesterolemia, the effects of diet vs. gastric bypass in diabetes, drug-coated balloons for dysfunctional dialysis arteriovenous fistulas, fracture risk vs. fracture prevention with bisphosphonates, and the challenges of “return to work” in an ongoing pandemic; a review article on trigeminal neuralgia; a case report of a woman with altered mental status and weakness on the left side; and Perspective articles on low-threshold buprenorphine initiation, on when prescribing isn’t enough, on the death throes of Mercy, and on when the EMR stole a doctor’s pen. Supplement to the New England Journal of Medicine, Vol. 383, No. 8.
August 19, 2020
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NEJM This Week — August 13, 2020

Featuring articles on azacitidine plus venetoclax in AML, compression for recurrent cellulitis of the leg, decreased population-based mortality from lung cancer, the United States and the WHO, the need for a tighter particulate-matter air-quality standard, and bilirubin in IBD and pancreatitis; a review article on epigenetic therapies for cancer; a case report of a woman with a lung mass; and Perspective articles on whether we spend too much on health care, on people with hepatitis C who inject drugs, on hepatitis C treatment in correctional facilities, and on a national medical response to crisis. Supplement to the New England Journal of Medicine, Vol. 383, No. 7.
August 12, 2020
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NEJM This Week — August 6, 2020

Featuring articles on hydroxychloroquine for Covid-19 prophylaxis, subcutaneous or transvenous ICD therapy, Zika virus disease in Colombia, ofatumumab vs. teriflunomide in multiple sclerosis, and spending after state specialty-drug out-of-pocket caps; a review article on native-valve infective endocarditis; a Clinical Problem-Solving on being led astray; and Perspective articles on the National Academy of Medicine and the quality of health care, on care churn, on mental health and the Covid-19 pandemic, and on preventing a parallel pandemic. Supplement to the New England Journal of Medicine, Vol. 383, No. 6.
August 5, 2020
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NEJM This Week — July 30, 2020

Featuring articles on nirsevimab for the prevention of RSV disease, RSV vaccination during pregnancy to protect infants, uterine-artery embolization or myomectomy for uterine fibroids, a trial of a therapeutic anti–yellow fever virus antibody, and a bad acid trip for sarcomas; a review article on chronic lymphocytic leukemia; a case report of a woman with chest pain, dyspnea, and shock; and Perspective articles on health care as an ongoing policy project, on Covid’s color line, and on the illusion of inclusion. Supplement to the New England Journal of Medicine, Vol. 383, No. 5.
July 29, 2020
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About NEJM This Week – Audio Summaries

The New England Journal of Medicine (NEJM) Weekly Audio Summary RSS Feed. NEJM is a weekly general medicinal journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

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