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Clinical Research and Drug Discovery Podcasts

Clinical Research Podcasts

Latest Episodes

NEJM This Week — July 22, 2021

Featuring articles on PCI guided by FFR or angiography for STEMI, pimavanserin for dementia-associated psychosis, Covid-19 prevention and attenuation with mRNA vaccines, second-line treatment of HIV-1 infection in Sub-Saharan Africa, and racial inequality in prescription opioid receipt; a review article on substance use among men who have sex with men; a case report of a woman with cognitive impairment, headache, and memory loss; and Perspective articles on medical–financial partnerships, on Virchow at 200 and Lown at 100, and on one hundred years of insulin for some. Supplement to the New England Journal of Medicine, Vol. 385, No. 4.
July 21, 2021
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NEJM This Week — July 15, 2021

Featuring articles on rehabilitation after hospitalization for heart failure, detecting speech in a paralyzed person with anarthria, ruxolitinib for chronic graft-versus-host disease, BNT162b2 vaccination against Covid-19 in 12-to-15-year-old adolescents, and inhibiting PD-L1 in hepatocellular carcinoma; a review article on the initial management of seizure in adults; a case report of a pregnant woman with fever, abdominal pain, and headache; and Perspective articles on averting future vaccine inequity, on scaling up Covid-19 vaccination in Africa, and on a medical home. Supplement to the New England Journal of Medicine, Vol. 385, No. 3.
July 14, 2021
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NEJM This Week — July 8, 2021

Featuring articles on fetal surgery for severe left diaphragmatic hernia and for moderate left diaphragmatic hernia, comparisons of interleukin-17 inhibitors in psoriasis, and SARS-CoV-2 variants and vaccines; a review article on hematuria in adults; a case report of a man with ataxia; and Perspective articles on addressing vaccine hesitancy in BIPOC communities, on Covid-19 vaccine follow-through, and on the CT scan after 50 years. Supplement to the New England Journal of Medicine, Vol. 385, No. 2.
July 7, 2021
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NEJM This Week — July 1, 2021

Featuring articles on the treatment of multisystem inflammatory syndrome in children, a transglutaminase 2 inhibitor for celiac disease, daratumumab in light-chain amyloidosis, embryo selection in vitro, and clonal peregrinations in the placenta; a review article on cerebral venous thrombosis; a Clinical Problem-Solving on a brewing back pain; and Perspective articles on the learning health system, on whether learning is worth the trouble, and on Covid-19 and the investigator pipeline. Supplement to the New England Journal of Medicine, Vol. 385, No. 1.
June 30, 2021
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NEJM This Week — June 24, 2021

We discuss the latest in medical research and ideas.
June 23, 2021
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NEJM This Week — June 17, 2021

Featuring articles on mRNA Covid-19 vaccine safety in pregnant persons, hypothermia or normothermia after cardiac arrest, rituximab vs. mycophenolate mofetil for pemphigus, sudden cardiac death in persons with HIV, and SARS-CoV-2 vaccine design; a review article on infections in patients with cirrhosis; a case report of a man with cough, fever, and shortness of breath; and Perspective articles on promoting equity for women in medicine, on misogyny in medicine, and on escaping the labyrinth. Supplement to the New England Journal of Medicine, Vol. 384, No. 24.
June 16, 2021
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NEJM This Week — June 10, 2021

Featuring articles on wolbachia-infected mosquito deployments for dengue, Ad26.COV2.S vaccine efficacy against Covid-19, thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination, variant SARS-CoV-2 infection after vaccination, and on diabetes treatment and control in U.S. adults from 1999 to 2018; a review article on recent advances in the treatment of melanoma; a case report of a woman with pain, swelling, and ecchymosis of the left arm; and Perspective articles on HIPAA at 25, on HIPAA and the leak of “deidentified” EHR data, and on what did I sign up for? Supplement to the New England Journal of Medicine, Vol. 384, No. 23.
June 9, 2021
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NEJM This Week — June 3, 2021

Featuring articles on left atrial appendage occlusion during cardiac surgery, thrombosis after ChAdOx1 nCoV-19 vaccination, adjuvant nivolumab for invasive urothelial carcinoma, a meningococcal X vaccine in Mali, and irritable bowel syndrome and immunity; a review article on HIV infection; a Clinical Problem-Solving describing a hypertensive heartbreak; and Perspective articles on women’s health; on institutional problems, individual solutions; and on merging mortalities. Supplement to the New England Journal of Medicine, Vol. 384, No. 22.
June 2, 2021
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NEJM This Week — May 27, 2021

Featuring articles on aspirin dosing in cardiovascular disease, antibiotic therapy for prosthetic joint infection, gene therapy for adenosine deaminase deficiency, a novel microRNA in acute myocarditis, and immediate “kangaroo mother care” of low-birth-weight infants; a review article on somatic mutations in “benign” disease; a case report of a woman with abdominal pain and aortic dilatation; and Perspective articles on the “legal epidemiology” of pandemic control, on a hidden opportunity, and on dilemmas of double consciousness. Supplement to the New England Journal of Medicine, Vol. 384, No. 21.
May 26, 2021
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NEJM This Week — May 20, 2021

Featuring articles on efficacy of the ChAdOx1 nCoV-19 vaccine against the B.1.351 variant, NVX-CoV2373 vaccine efficacy against B.1.351 in South Africa, endovascular therapy for basilar-artery stroke, intensive or standard blood-pressure control, and on gene editing for congenital neutropenia; a review article on monoclonal gammopathy of renal significance; a case report of a woman with nausea, diarrhea, and acute kidney failure; and Perspective articles on minority tax reform, on training future health justice leaders, and on finding a way to break through the fog. Supplement to the New England Journal of Medicine, Vol. 384, No. 20.
May 19, 2021
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NEJM This Week — May 13, 2021

We discuss the latest in medical research and ideas.
May 12, 2021
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NEJM This Week — May 6, 2021

Featuring articles on a trial of an antibody to amyloid in Alzheimer’s disease, short-course treatment of tuberculosis, weight loss maintenance with exercise and liraglutide, dexamethasone and surgical-site infection, a fountain of youthful retinal ganglion cells, and decoupling crisis response from policing; a review article on gastric emptying abnormalities in diabetes; a Clinical Problem-Solving on the inside and out; and Perspective articles on understanding and mitigating health inequities, on designing an independent public health agency, and on losing touch. Supplement to the New England Journal of Medicine, Vol. 384, No. 18.
May 5, 2021
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NEJM This Week — April 29, 2021

Featuring articles on vadadustat in non–dialysis-dependent chronic kidney disease, vadadustat for anemia in patients undergoing dialysis, oncolytic HSV therapy in pediatric glioma, blood-loss prevention after cesarean delivery, and diversity of the national medical student body; a review article on postpartum hemorrhage; a case report of a newborn girl with a neck mass; and Perspective articles on Australian firearm regulation at 25, on vaccination plus decarceration, and on the Zoom family meeting. Supplement to the New England Journal of Medicine, Vol. 384, No. 17.
April 28, 2021
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NEJM This Week — April 22, 2021

Featuring articles on interleukin-6 receptor blockade in severe Covid-19, tocilizumab in severe Covid-19 pneumonia, a microbiota-directed food supplement for malnutrition, sacituzumab govitecan in triple-negative breast cancer, and fighting SARS-CoV-2 with nanobodies; a review article on adrenal incidentaloma; a case report of a man with a rash on the scalp and face; and Perspective articles on advancing President Biden’s equity agenda, on encouraging acceptance of Covid-19 vaccines, and on Nanima. Supplement to the New England Journal of Medicine, Vol. 384, No. 16.
April 21, 2021
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NEJM This Week — April 15, 2021

Featuring articles on hypothermic machine perfusion in liver transplantation, a trial of psilocybin for depression, the effectiveness of the BNT162b2 mRNA vaccine in Israel, sedation in mechanically ventilated adults with sepsis, and soothing science skepticism; a review article on glomerular filtration and albuminuria; a case report of a woman with fever, flank pain, and inguinal lymphadenopathy; and Perspective articles on new legislation on out-of-network billing, on remote patient monitoring, and on remembering the Freedom House Ambulance Service. Supplement to the New England Journal of Medicine, Vol. 384, No. 15.
April 14, 2021
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NEJM This Week — April 8, 2021

Featuring articles on lenvatinib plus pembrolizumab in renal cell cancer, oxygenation targets for acute respiratory failure, cardiovascular risk and glycemic index, sutimlimab in cold agglutinin disease, extending life span in a mouse model of progeria, and overcoming Covid vaccine hesitancy; a review article on vestibular schwannomas; a case report of a man with depressed mood, unsteady gait, and urinary incontinence; and Perspective articles on combatting vaccine nationalism, on vancomycin infusion reaction, and on minds in crisis in a city in crisis. Supplement to the New England Journal of Medicine, Vol. 384, No. 14.
April 7, 2021
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NEJM This Week — April 1, 2021

Featuring articles on adjuvant nivolumab in esophageal cancer, sotatercept for pulmonary arterial hypertension, lumasiran for primary hyperoxaluria type 1, upadacitinib for psoriatic arthritis, and an Ebola relapse leading to transmission; a review article on glucose-lowering drugs to prevent cardiovascular disease; a Clinical Problem-Solving on stalking the diagnosis; and Perspective articles on emerging infectious diseases, on ensuring that LGBTQI+ people count, and on the first Black woman to earn a medical degree in the United States. Supplement to the New England Journal of Medicine, Vol. 384, No. 13.
March 31, 2021
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NEJM This Week — March 25, 2021

Featuring articles on the efficacy of the ALVAC–gp120 HIV vaccine, a JAK inhibitor or interleukin-4 blockade for atopic dermatitis, semaglutide for nonalcoholic steatohepatitis, enfortumab vedotin for relapse of urothelial cancer, the link between cancer and obesity, and embracing genetic diversity to improve Black health; a review article on atopic dermatitis; a case report of a boy with headache, abdominal pain, and hypertension; and Perspective articles on progress in vaccine technology, on addressing workforce diversity, and on the good fit. Supplement to the New England Journal of Medicine, Vol. 384, No. 12.
March 24, 2021
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NEJM This Week — March 18, 2021

Featuring articles on once-weekly semaglutide in adults with overweight or obesity, neutralizing antibodies to prevent HIV-1 infection, passive immunotherapy in patients with Covid-19, inhibition of C3 in paroxysmal nocturnal hemoglobinuria, and the political nature of sex; a review article on extrahepatic manifestations of chronic HCV infection; a case report of a woman with cholangiocarcinoma; and Perspective articles on private equity and physician medical practices, on the good doctor, and on the intern. Supplement to the New England Journal of Medicine, Vol. 384, No. 11.
March 17, 2021
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NEJM This Week — March 11, 2021

Featuring articles on a randomized trial of gestational diabetes screening, a neutralizing monoclonal antibody for hospitalized patients with Covid-19, risdiplam in type 1 spinal muscular atrophy, genome sequencing in myeloid cancers, a cautionary note about round spermatid injection, and supplying insulin while evading immunity; a review article on epistaxis; a case report of a man with shock, multiple organ failure, and rash; and Perspective articles on supporting clinical trainees with disabilities, on doctors with mental illness and structural barriers to disclosure, and on being breathless. Supplement to the New England Journal of Medicine, Vol. 384, No. 10.
March 10, 2021
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NEJM This Week — March 4, 2021

Featuring articles on baricitinib plus remdesivir for adults with Covid-19, albumin infusions in patients with cirrhosis, a trial of terlipressin for hepatorenal syndrome, nivolumab plus cabozantinib in renal-cell carcinoma, and on misrepresenting race; a review article on diffuse large B-cell lymphoma; a Clinical Problem-Solving describing a treacherous course; and Perspective articles on conquering atherosclerotic cardiovascular disease, on reform of payment for primary care, and on being without sanctuary. Supplement to the New England Journal of Medicine, Vol. 384, No. 9.
March 3, 2021
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NEJM This Week — February 25, 2021

Featuring articles on dexamethasone treatment in Covid-19, BCMA-specific CAR T cells in refractory myeloma, a cholinergic agonist and peripheral antagonist for schizophrenia, the Center for Medicare and Medicaid Innovation at 10 years, inflammation in ALS, and how structural racism works; a review article on β-thalassemias; a case report of a man with eye pain and decreased vision; and Perspective articles on last-mile logistics of Covid-19 vaccination, on telemedicine and medical licensure, and on the inequity of isolation. Supplement to the New England Journal of Medicine, Vol. 384, No. 8.
February 24, 2021
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NEJM This Week — February 18, 2021

Featuring articles on a C5a receptor inhibitor for ANCA vasculitis, convalescent plasma in Covid-19, relugolix combination therapy for uterine fibroid symptoms, and promoting Covid-19 vaccination in the United States; a review article on maintaining safety with SARS-CoV-2 vaccines; a case report of a man with delirium and renal insufficiency; and Perspective articles on vaccinating children against Covid-19 and on the FDA’s experience with Covid-19 antibody tests. Supplement to the New England Journal of Medicine, Vol. 384, No. 7.
February 17, 2021
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NEJM This Week — February 11, 2021

Featuring articles on repurposed antiviral drugs for Covid-19, a tirbanibulin ointment for actinic keratosis, a vestibular implant for bilateral vestibular hypofunction, antibodies and SARS-CoV-2 infection in health workers, a randomized trial of an HCV vaccine regimen, and regulatory T cells in multiple sclerosis; a review article on circadian mechanisms in medicine; a case report of a woman with dyspnea on exertion and abnormal findings on chest imaging; and Perspective articles on the future of drug-pricing transparency, on a shared evaluation platform for medical training, and on lessons from the Irish wake. Supplement to the New England Journal of Medicine, Vol. 384, No. 6.
February 10, 2021
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