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Clinical Research and Drug Discovery Podcasts

Clinical Research Podcasts
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Latest Episodes

NEJM This Week — March 4, 2021

Featuring articles on baricitinib plus remdesivir for adults with Covid-19, albumin infusions in patients with cirrhosis, a trial of terlipressin for hepatorenal syndrome, nivolumab plus cabozantinib in renal-cell carcinoma, and on misrepresenting race; a review article on diffuse large B-cell lymphoma; a Clinical Problem-Solving describing a treacherous course; and Perspective articles on conquering atherosclerotic cardiovascular disease, on reform of payment for primary care, and on being without sanctuary. Supplement to the New England Journal of Medicine, Vol. 384, No. 9.
March 3, 2021
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NEJM This Week — February 25, 2021

Featuring articles on dexamethasone treatment in Covid-19, BCMA-specific CAR T cells in refractory myeloma, a cholinergic agonist and peripheral antagonist for schizophrenia, the Center for Medicare and Medicaid Innovation at 10 years, inflammation in ALS, and how structural racism works; a review article on β-thalassemias; a case report of a man with eye pain and decreased vision; and Perspective articles on last-mile logistics of Covid-19 vaccination, on telemedicine and medical licensure, and on the inequity of isolation. Supplement to the New England Journal of Medicine, Vol. 384, No. 8.
February 24, 2021
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NEJM This Week — February 18, 2021

Featuring articles on a C5a receptor inhibitor for ANCA vasculitis, convalescent plasma in Covid-19, relugolix combination therapy for uterine fibroid symptoms, and promoting Covid-19 vaccination in the United States; a review article on maintaining safety with SARS-CoV-2 vaccines; a case report of a man with delirium and renal insufficiency; and Perspective articles on vaccinating children against Covid-19 and on the FDA’s experience with Covid-19 antibody tests. Supplement to the New England Journal of Medicine, Vol. 384, No. 7.
February 17, 2021
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NEJM This Week — February 11, 2021

Featuring articles on repurposed antiviral drugs for Covid-19, a tirbanibulin ointment for actinic keratosis, a vestibular implant for bilateral vestibular hypofunction, antibodies and SARS-CoV-2 infection in health workers, a randomized trial of an HCV vaccine regimen, and regulatory T cells in multiple sclerosis; a review article on circadian mechanisms in medicine; a case report of a woman with dyspnea on exertion and abnormal findings on chest imaging; and Perspective articles on the future of drug-pricing transparency, on a shared evaluation platform for medical training, and on lessons from the Irish wake. Supplement to the New England Journal of Medicine, Vol. 384, No. 6.
February 10, 2021
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NEJM This Week — February 4, 2021

Featuring articles on an mRNA-1273 vaccine to prevent Covid-19, a trial of hydroxychloroquine to prevent Covid-19, breast cancer risk revisited, much ado about certain breast cancer genes, and race and genetic ancestry in medicine; a review article on antithrombotic therapy after acute coronary syndromes; a Clinical Problem-Solving describing the hunt for a diagnosis; and Perspective articles on vaccine innovations, on the search of a better equation, and on learning about end-of-life care from Grandpa. Supplement to the New England Journal of Medicine, Vol. 384, No. 5.
February 3, 2021
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NEJM This Week — January 28, 2021

Featuring articles on cryoablation for atrial fibrillation, inhaled treprostinil in interstitial lung disease, a levonorgestrel vs. copper IUD for emergency contraception, the return of cardiac activity after withdrawal of life support, and antigen presentation by B cells in multiple sclerosis; a review article on atrial fibrillation; a case report of a man with transient vision loss; and Perspective articles on reimagining infective endocarditis care amid the opioid epidemic, on a medical “ecology of attention”, and on the surgeon and the mother. Supplement to the New England Journal of Medicine, Vol. 384, No. 4.
January 27, 2021
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NEJM This Week — January 21, 2021

Featuring articles on inhibiting BCL11A to treat sickle cell disease and β-thalassemia, a polypill with or without aspirin in primary prevention, and neutralizing-antibody therapy in Covid-19; a review article on the effects of infection on natural immunity; a case report of a pregnant woman with ventricular tachycardia and shock; and Perspective articles on testing in a pandemic, on the Supreme Court and pandemic controls, and on incarceration and social death. Supplement to the New England Journal of Medicine, Vol. 384, No. 3.
January 20, 2021
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NEJM This Week — January 14, 2021

Featuring articles on omecamtiv mecarbil in systolic heart failure, sotagliflozin in diabetes with heart failure, sotagliflozin for heart failure in diabetes and kidney disease, bupropion and naltrexone for methamphetamine use, and procuring oligodendrocytes after spinal cord injury; a review article on Ewing’s sarcoma; a case report of a woman with lethargy and altered mental status; and Perspective articles on the Purdue Pharma opioid settlement, on drug-coated devices for peripheral arterial disease, and on the doctor as street-level bureaucrat. Supplement to the New England Journal of Medicine, Vol. 384, No. 2.
January 13, 2021
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NEJM This Week — January 7, 2021

Featuring articles on sitagliptin for prevention of acute GVHD, tocilizumab in Covid-19 pneumonia, rilonacept in recurrent pericarditis, vaginal mother-to-child transmission of cancer, and on whether the melanoma epidemic is real; a review article on osteoarthritis of the knee; a Clinical Problem-Solving on breathing for two; and Perspective articles on human molecular genetics and genomics, on Covid-19 and the undocumented Latinx community, and on the stress of Bayesian medicine. Supplement to the New England Journal of Medicine, Vol. 384, No. 1.
January 6, 2021
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NEJM This Week — December 31, 2020

Featuring articles on the safety and efficacy of an RNA-based SARS-CoV-2 vaccine, dexamethasone in chronic subdural hematoma, sleuthing out a severe adult inflammatory disorder, hemoglobin transfusion thresholds in infants, and vaccinating against SARS-CoV-2; a review article on the pathophysiology of inflammatory bowel diseases; a case report of a man with memory loss and odd behavior; and Perspective articles on reimagining how policymakers identify safety-net hospitals, on Medicaid and child health equity, on the FDA approval of remdesivir, and on whiteouts. Supplement to the New England Journal of Medicine, Vol. 383, No. 27.
December 30, 2020
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NEJM This Week — December 24, 2020

Featuring articles on ultrasound subthalamotomy for Parkinson’s disease, antenatal dexamethasone for early preterm birth, oral azacitidine maintenance therapy for AML, paclitaxel-coated devices in peripheral artery disease, and seizure frequency during pregnancy; a review article on estrogen receptor–positive breast cancer; a case report of a man with headache and Covid-19; and Perspective articles on the gift; on new order, new hope; on resilience in the face of Covid-19; and on holding up. Supplement to the New England Journal of Medicine, Vol. 383, No. 26.
December 23, 2020
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NEJM This Week — December 17, 2020

Featuring articles on SARS-CoV-2 transmission among Marine recruits, SARS-CoV-2 transmission on an aircraft carrier, an mRNA vaccine against Covid-19 in older adults, a phase 1 trial of an RNA-based Covid-19 vaccine, and the cardiomyocyte and the mighty mitochondrion; a review article on severe Covid-19; a case report of a boy with seizure and hypocalcemia; and Perspective articles on health coverage and care for transgender people, on rethinking sex designations on birth certificates, on being interviewed while Black, and on the caregiver. Supplement to the New England Journal of Medicine, Vol. 383, No. 25.
December 16, 2020
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NEJM This Week — December 10, 2020

Featuring articles on lipid lowering through activation of lipoprotein lipase, on a SARS-CoV-2 recombinant nanoparticle vaccine, on tocilizumab in Covid-19, and on survival with olaparib in prostate cancer; a review article on spontaneous coronary-artery dissection; a case report of a man with cancer and acute hypoxemia; and Perspective articles on the discovery of hepatitis C, on how Medicare Part D has failed to deliver savings to older adults, on a pandemic within a pandemic, and on Telephone. Supplement to the New England Journal of Medicine, Vol. 383, No. 24.
December 9, 2020
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NEJM This Week — December 3, 2020

Featuring articles on pembrolizumab in microsatellite-unstable colorectal cancer, the effect of finerenone on chronic kidney disease outcomes, person-to-person spread of Andes virus, malaria chemoprophylaxis in sub-saharan Africa, and epigenetic regulation in prostate cancer; a review article on cytokine storm; a Clinical Problem-Solving on looking for the outsider; and Perspective articles on solving population-wide obesity, on the bottom of the health care rationing iceberg, on understanding questions and answers about Covid-19 vaccination, and on why we need black physicians in academic medicine. Supplement to the New England Journal of Medicine, Vol. 383, No. 23.
December 2, 2020
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NEJM This Week — November 26, 2020

We discuss the latest in medical research and ideas.
November 25, 2020
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NEJM This Week — November 19, 2020

Featuring articles on golimumab and beta-cell function in type 1 diabetes, lorlatinib in ALK-positive lung cancer, hydroxychloroquine in patients with Covid-19, hydroxychloroquine with or without azithromycin in Covid-19, crafty killing of pathogenic microbes in the placenta, and physician–public defender collaboration; a review article on endometrial cancer; a case report of a woman with dark urine and weakness; and Perspective articles on the regulation of over-the-counter hearing aids, on transgender women on college athletic teams, and on unclaimed bodies in the anatomy lab. Supplement to the New England Journal of Medicine, Vol. 383, No. 21.
November 18, 2020
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NEJM This Week — November 12, 2020

We discuss the latest in medical research and ideas.
November 11, 2020
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NEJM This Week — November 5, 2020

We discuss the latest in medical research and ideas.
November 4, 2020
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NEJM This Week — October 29, 2020

Featuring articles on osimertinib adjuvant therapy in EGFR-mutated non–small-cell lung cancer, a durable humoral response to SARS-CoV-2, low-dose edoxaban in atrial fibrillation, and exome sequencing for nonimmune hydrops fetalis; a review article on mild or moderate Covid-19; a case report of a man with chronic kidney disease; and Perspective articles on Operation Warp Speed’s strategy and approach, on evaluating and deploying Covid-19 vaccines, on pharmaceutical industry caution vs. federal acceleration of Covid-19 vaccine approval, and on the new stability. Supplement to the New England Journal of Medicine, Vol. 383, No. 18.
October 28, 2020
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NEJM This Week — October 22, 2020

Featuring articles on dasatinib–blinatumomab in Ph-positive ALL, an anti–Siglec-8 antibody in gastritis and duodenitis, inhaled molgramostim therapy in autoimmune pulmonary alveolar proteinosis, treating Middle East Respiratory Syndrome, fibroblasts in rheumatoid arthritis, and how can we bridge the partisan divide and conquer Covid; a review article on sensory ganglionopathy; a case report of a man with abdominal pain, joint swelling, and skin lesions; and Perspective articles on whether the elections can end the health reform stalemate, on insurance coverage after job loss, on redoubling efforts to help Americans quit smoking, and on taking back our voices. Supplement to the New England Journal of Medicine, Vol. 383, No. 17.
October 21, 2020
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NEJM This Week — October 15, 2020

Featuring articles on upadacitinib or abatacept in rheumatoid arthritis, a nimble GWAS on Covid-19, life expectancy after bariatric surgery, an mRNA–based Covid-19 vaccine in nonhuman primates, and selection against pathogenic mitochondrial DNA; a review article on autophagy in human diseases; a case report of a man with confusion, fatigue, and garbled speech; and Perspective articles on health policy in a Biden administration or after a Trump election victory, on Covid-19 and the mandate to redefine preventive care, and on when all you have is quality of life. Supplement to the New England Journal of Medicine, Vol. 383, No. 16.
October 14, 2020
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NEJM This Week — October 8, 2020

Featuring articles on empagliflozin in heart failure, cardiovascular outcomes with ertugliflozin in diabetes, dapagliflozin in chronic kidney disease, single or dual antiplatelet treatment after TAVI, on dying in a leadership vacuum, Covid-19 and implications for the health care system, and mending mitochondrial mutation; a review article on secondary mitral regurgitation; a case report of a man with lymphoma and abdominal pain; and Perspective articles on the role of market forces in U.S. health care, on embracing antiracism in medicine, and on improving clinical trial enrollment. Supplement to the New England Journal of Medicine, Vol. 383, No. 15.
October 7, 2020
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NEJM This Week — October 1, 2020

Featuring articles on early rhythm-control therapy for atrial fibrillation, evolocumab in heterozygous pediatric familial hypercholesterolemia, atezolizumab in non–small-cell lung cancer, HPV vaccination and the risk of cervical cancer, and physician work hours and the gender pay gap; a review article on myelodysplastic syndromes; a Clinical Problem-Solving describing parroting lymphoma; and Perspective articles on health in aging, on ensuring uptake of vaccines against SARS-CoV-2, on an innovative approach to reducing gun suicides, and on the ritual of the table. Supplement to the New England Journal of Medicine, Vol. 383, No. 14.
September 30, 2020
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NEJM This Week — September 24, 2020

Featuring articles on a RAS oncogene inhibitor at last, avelumab maintenance therapy in bladder cancer, lower-dose zinc for childhood diarrhea, antisense oligonucleotides for hereditary angioedema, and sussing out the sestrins; a review article on congenital adrenal hyperplasia due to 21-hydroxylase deficiency; a case report of a man with sudden cardiac arrest; and Perspective articles on competing visions for the future of health policy, on assessing the safety of glucose-lowering drugs, on Ebola response priorities in the time of Covid-19, and on a farewell gift from a mother. Supplement to the New England Journal of Medicine, Vol. 383, No. 13.
September 23, 2020
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COVID-19 Miniseries Episode 62: Mayo Clinic Q&A COVID-19 Virus, Variants and Vaccines Update