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Clinical Research and Drug Discovery Podcasts

Clinical Research Podcasts

Latest Episodes

NEJM This Week — May 16, 2024

Featuring articles on andexanet and factor Xa inhibitor–associated hemorrhage, perioperative nivolumab in resectable lung cancer, olezarsen for familial chylomicronemia syndrome, and olezarsen for hypertriglyceridemia; a review article on climate change, extreme heat, and health; a case report of a woman with worsening rash; and Perspective articles on focusing on health care equity, on underestimated challenges for social care initiatives, on integrating public health and health care, and on learning to say goodbye. Supplement to the New England Journal of Medicine, Vol. 390, No. 19.
May 15, 2024
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Driving Oncology Trials to the Community

2024-05-10 Hosts Amir Kalali and Jane Myles were joined by Dr. David Waterhouse (Oncology & Hematology Care) to discuss transforming clinical trials to enable cancer patients to participate closer to home.The paper discussed during the session is available here.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership and our work at www.dtra.org.
May 13, 2024
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Leveraging oscillometry for enhanced patient care in COPD

Dr. Frederik Trinkmann is the deputy head of Thoraxklinik at Heidelberg University.  Trained as a medical specialist for intensive care medicine.  He is a distinguished researcher with >60 publications. In this episode, he elaborates on his personal journey to adopting oscillometry and how he leverages oscillometry to make clinical decisions for enhanced patient care in COPD.
May 10, 2024
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NEJM This Week — May 9, 2024

Featuring articles on gene editing in severe sickle cell disease and in transfusion-dependent β-thalassemia, thrombectomy for stroke with a large infarct, and recombinant ADAMTS13 in life-threatening immune thrombotic thrombocytopenic purpura; a review article on taste physiology; a case report of a woman with back pain, leg stiffness, and falls; and Perspective articles on the public good on the docket, on reengineering addiction, on welcoming the era of gene editing in medicine, and on all’s fair in love and work. Supplement to the New England Journal of Medicine, Vol. 390, No. 18.
May 8, 2024
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Resilient Roots: Indigenous Health Equity

Join us for this episode of Aging Fast & Slow as we explore the structural resilience of Indigenous Peoples amidst systemic inequities. Dr. Allison Kelliher, Associate Faculty for Indigenous Knowledge and Practice Systems at Johns Hopkins School of Nursing, sheds light on pathways to positive change and health equity. With her unique background as an Alaska Native Traditional Healer and Integrative Physician, Dr. Kelliher offers invaluable insights into promoting resilience and well-being among Indigenous communities. References United Nations Economic and Social Council. Indigenous determinants of health in the 2030 Agenda for Sustainable Development. April 2023. Kelliher, A et al. Indigenous determinants of health: a unified call for progress. The Lancet. June 21, 2023. Kelliher, A et al. Status of Maternal Cardiovascular Health in American Indian and Alaska Native Individuals: A Scientific Statement From the American Heart Association. Circulation: Cardiovascular Quality and Outcomes. June 2023.
May 7, 2024
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Building Diversity & Inclusion into Clinical Trials

2024-04-26 Our hosts Craig Lipset, Amir Kalali, and Jane Myles were joined by Otis Johnson (Trial Equity) and Jeffrey Zucker (Tekton Research) to share about how to expand clinical research opportunities to diverse populations. Trial Equity has a training curriculum to help companies achieve this goal of expanding access to patients that we explored during the conversation.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership and our work at www.dtra.org.
May 6, 2024
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Unlocking Digital Health Tech in Clinical Trials

2024-05-03 Hosts Amir Kalali, Craig Lipset, and Jane Myles were joined by Moe Alsumidaie (The Clinical Trial Vanguard) for a robust discussion around digital health technologies and how they can be best utilizing in advancing clinical trials.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership and our work at www.dtra.org.
May 6, 2024
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NEJM This Week — May 2, 2024

Featuring articles on a monoclonal antibody to prevent malaria, apolipoprotein A1 and outcomes after myocardial infarction, transcatheter or surgical treatment of aortic-valve stenosis, and recombinant ADAMTS13 in congenital thrombotic thrombocytopenic purpura; a review article on cryptococcal disease in diverse hosts; a Clinical Problem-Solving on the meat of the matter; and a Perspective on Journal voices in the civil rights era. Supplement to the New England Journal of Medicine, Vol. 390, No. 17.
May 1, 2024
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NEJM This Week — April 25, 2024

Featuring articles on empagliflozin after acute myocardial infarction, CD7 CAR T cells with allogeneic stem-cell transplantation, FFR-guided complete revascularization for STEMI, and nutrition for moderate-to-late preterm infants; a review article on age-related hearing loss; a case report of a man with leg weakness; and Perspective articles on hospital consolidation and physician unionization, on the myth of the free market for pharmaceuticals, and on going beyond code status. Supplement to the New England Journal of Medicine, Vol. 390, No. 16.
April 24, 2024
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Site Needs for Decentralized Trials

2022-10-14 Host Craig Lipset was joined by a powerhouse of site leaders for a great conversation around what sites need to make DCTs a success. Casey Orvin (CenExel), Lori Wright (ERG), Irfan Khan (Circuit Clinical), Jimmy Bechtl (SCRS), and Paul Evans (Velocity Clinical Research) joined for the conversation.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
April 22, 2024
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NEJM This Week — April 18, 2024

Featuring articles on adjuvant pembrolizumab after surgery in renal-cell carcinoma, beta-blockers after MI with preserved ejection fraction, a microaxial flow pump for STEMI and cardiogenic shock, and semaglutide in patients with heart failure and diabetes; a review article on retinoblastoma; a case report of a woman with confusion, aphasia, and abnormal head imaging; and Perspectives on expanding applications of clinical genetic testing, on twenty-five years after Columbine, on advocating for a healthy response to climate change, and on the silver resident. Supplement to the New England Journal of Medicine, Vol. 390, No. 15.
April 17, 2024
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Novel Platform & DCTs Drive Innovation

2024-04-12 Hosts Amir Kalali, MD and Jane Myles were joined by Stacey Adam, Vice President, Science Partnerships for the Foundation for National Institute of Health. She shared about her experiences with platform trials, DCT methods, and how they are working to drive innovation further for patients.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
April 15, 2024
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NEJM This Week — April 11, 2024

Featuring articles on alectinib in ALK-positive lung cancer, minimally invasive removal of cerebral hematomas, and CAR T-cell–mediated responses in recurrent glioblastoma; a review article on energy and macronutrients across the life span; a case report of a woman with falls and cognitive decline; a Medicine and Society on money as medicine; and Perspectives on back to the future in Alabama, on the end of B/Yamagata influenza transmission, and on the plight of DEI leaders. Supplement to the New England Journal of Medicine, Vol. 390, No. 14.
April 10, 2024
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What Evidence do you need for DCTs and how to find it?

2024-04-05 Hosts Craig Lipset, Amir Kalali, and Jane Myles were joined by several members of the research community for a robust discussion about how to find evidence of impact, our efforts to make it available in the DTRA Library, and ways we can continue working to find this evidence to drive adoption of DCTs.The DTRA Library can be accessed here and is available to all. We are asking for you to make submissions of additional case studies, white papers, articles, and more so we can continue to grow the library for all.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
April 8, 2024
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NEJM This Week — April 4, 2024

Featuring articles on omitting axillary dissection in breast cancer with sentinel-node metastasis, a trial of lixisenatide in early Parkinson’s disease, nirmatrelvir–ritonavir in outpatients with Covid-19, and hospitalization for chronic kidney disease; a review article on the prevention of cardiovascular disease in type 1 diabetes; a case report of a woman with hyperglycemia refractory to insulin; and a Perspective article on Nazism and the Journal. Supplement to the New England Journal of Medicine, Vol. 390, No. 13.
April 3, 2024
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Clinical Trial Matching Solutions: Is it Solved?

2024-03-29 Hosts Craig Lipset, Amir Kalali, and Jane Myles were joined by Todd Georgieff (futurpositif - Digital Clinical Trials Consulting), Jennifer Clauson (Dyania Health) and Brandon Li (Power) for a discussion around the approaches to matching patients for clinical trials and different methods and ideas on how we can better the trial matching process today.
April 2, 2024
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Policy Pathways to Community Resilience

Policies are pivotal for shaping the structural resilience of communities, influencing their ability to navigate and overcome adversity. In this episode, we are joined by Dr. Vincent Guilamo-Ramos, Director of The Institute for Policy Solutions at the Johns Hopkins School of Nursing, to explore how policies, social determinants of health, and structural resilience intersect to shape community well-being and examine how thoughtful policy frameworks can either bolster or hinder a community's ability to overcome adversity.  References Guilamo-Ramos V et al. Nurse-led approaches to address social determinants of health and advance health equity: A new framework and its implications. Nursing Outlook. November/December 2023. Guilamo-Ramos V et al. Paternal Communication and Sexual Health Clinic Visits Among Latino and Black Adolescent Males With Resident and Nonresident Fathers. Journal of Adolescent Health. September 2023. Guilamo-Ramos V et al. Community-engaged Mpox vaccination provides lessons for equitable health care in the United States. Nature Medicine. September 2023.
April 2, 2024
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Is there evidence for what eConsent features patients prefer?

2024-03-22 Hosts Craig Lipset and Jane Myles dove into a conversation with Andrew Mackinnon (Medable) about their work with Duke on patient preference in an eConsent study. Learn more about the Pilot Study here --> https://pilotfeasibilitystudies.biomedcentral.com/articles/10.1186/s40814-023-01432-wFollow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
March 25, 2024
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NEJM This Week — March 21, 2024

Featuring articles on autism and prenatal exposure to antiseizure medication, ribociclib plus endocrine therapy in early breast cancer, gene therapy for giant axonal neuropathy, and anti–interleukin-23 in immunodeficiency; a review article on wearable digital health technologies in clinical care; a case report of a man with a fall; and Perspective articles on physicians, spirituality, and compassionate care; on the risks posed by immediate release of test results to patients; and on what one author did not tell the medical student. Supplement to the New England Journal of Medicine, Vol. 390, No. 12.
March 20, 2024
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Growing Enthusiasm for DCTs in Pakistan

2024-03-15 Hosts Craig Lipset and Jane Myles were joined by Jonathan Ernst (PCM Trials) and Ghazala Kabani (Integrity ClinOps Consulting) for a discussion around the growing interest and excitement for decentralized clinical trials in Pakistan.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
March 18, 2024
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All About ViiV: An Interview with CEO Deborah Waterhouse at CROI 2024

ViiV Healthcare is the world’s  only pharmaceutical company dedicated exclusively to HIV, and in this episode, Ben meets its CEO, Deborah Waterhouse, to explore the company’s approach to HIV R&D and commercial success - as well as the controversies its global access strategy has attracted for its new long acting injectables. Deborah and Ben find they have much in common beyond both being Brits growing up in the 70s and 80s, from being students of the humanities choosing to make careers in health, to their favorite pop music.  https://viivhealthcare.com https://www.unaids.org/en https://www.who.int/health-topics/hiv-aids https://www.cdc.gov/hiv/default.html https://au.int/en/sa/oid #ViiV #pharma #HIV #AIDS #treatment #Prevention #PrEP #dualtherapy #longacting #injectables #globalaccess #globalequity #discrimination #positiveaction #womenleaders #IWD 
March 13, 2024
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NEJM This Week — March 14, 2024

Featuring articles on a blood-based test for colorectal cancer screening, a multitarget stool DNA test for colorectal cancer, iptacopan for paroxysmal nocturnal hemoglobinuria, and preterm birth and other outcomes of maternal RSV vaccination; a review article on cerebral cavernous malformations; a case report of a man with cardiac arrest, cardiogenic shock, and hypoxemia; and Perspective articles on vertical integration and American medicine; on aspirin, preeclampsia, and racism; and on a shift in the night. Supplement to the New England Journal of Medicine, Vol. 390, No. 11.
March 13, 2024
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Lab Specimen Logistics in Decentralized Trials

2022-04-29 Hosts Amir Kalali and Craig Lipset were joined by Shawn Tedman (ixlayer) and Beth Culver (MRN) to discuss lab specimens and the logistics of obtaining them from patients when the trials are being run from home.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
March 8, 2024
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Our Bodies, Our Rights, Our Choices.

This International Women’s Day, we’re sharing the mic with Frontline AIDS. Yvette Raphael reflects on the challenges and setbacks girls and women face around the world in 2024, in a hard hitting conversation with Frontline AIDS’ Yumnah Hattas, Toyin Chukwudozie Executive Director of Nigeria’s Education As A Vaccine, and Beirne Roose-Snyder, Senior Director of the Preclusion Project.  https://frontlineaids.org https://www.evanigeria.org https://apha.org.za https://www.thepreclusionproject.org https://www.unaids.org/en https://www.state.gov/pepfar https://www.project2025.org #IWD #HIV #AIDS #pepfar #womensrights #antiabortion #forcedbirth #neocolonialism #reproductivehealth #choiceagenda
March 8, 2024
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