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Clinical Research and Drug Discovery Podcasts

Clinical Research Podcasts

Latest Episodes

NEJM This Week — February 2, 2023

Featuring articles on baxdrostat for treatment-resistant hypertension, VV116 versus nirmatrelvir for Covid-19, hypothermia or machine perfusion in kidney donors, effectiveness of the 4CMenB vaccine in children, implications of the 2022 election for health policy, and animal models and psychedelic research; a review article on innate immunity; a Clinical Problem-Solving on a breathtaking discovery; and Perspective articles on facing the new Covid-19 reality and on equity in global health research. Supplement to the New England Journal of Medicine, Vol. 388, No. 5.
February 1, 2023
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NEJM This Week — January 26, 2023

Featuring articles on extracorporeal CPR for cardiac arrest, efanesoctocog alfa in severe hemophilia A, zanubrutinib in chronic lymphocytic leukemia, and on using rescaled cystatin C to estimate GFR; a review article on antiretroviral therapy and adverse pregnancy outcomes; a case report of a girl with abdominal pain and bloody diarrhea; and Perspective articles on regulating reproductive medicine without Roe, on sources of innovation in gene therapies, and on the promise. Supplement to the New England Journal of Medicine, Vol. 388, No. 4.
January 25, 2023
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NEJM This Week — January 19, 2023

Featuring articles on aspirin or heparin thromboprophylaxis after a fracture, omicron neutralization with a bivalent vaccine boost, futibatinib for intrahepatic cholangiocarcinoma, and psychosocial functioning in transgender youth; a review article on periprosthetic joint infection; a case report of a man with dizziness and altered mental status; and Perspective articles on social isolation and loneliness as medical issues, on Medicare overpayment for outpatient medication, on being better off at home, and on hope after firearm trauma. Supplement to the New England Journal of Medicine, Vol. 388, No. 3.
January 18, 2023
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The Epidemiology of COVID-19: Future Impacts, Research, & Response

In this episode I interview Dr. Matthew Lamb, an Assistant Professor of Epidemiology at the Columbia University Medical Center focusing on infectious disease prevention, treatment, and scale-up. We discuss types of epidemiological research that shape how we have responded and adapted, how the pandemic has changed COVID-19 research, health disparities, and how we’re determing long-term effects of Covid through different types of epidemiological studies.  Matthew Lamb, PhD is an epidemiologist focusing on infectious disease prevention, treatment, and scale-up. His research focuses on identifying best practices in public health approaches to HIV prevention, service delivery, and treatment in resource-limited settings. https://www.publichealth.columbia.edu/people/our-faculty/mrl2013#:~:text=Matthew%20Lamb%2C%20PhD%20is%20an,resource%2Dlimited%20settings.Dr.
January 12, 2023
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Intention to Treat

“Intention to Treat,” hosted by health care journalist Rachel Gotbaum, draws on the world-class expertise of the New England Journal of Medicine to present breaking news and incisive analysis of critical and timely issues in medicine and health care. Through interviews with NEJM editors, specialized experts, physicians, and affected patients, each episode explores a story-behind-the-story, giving listeners needed context and a deeper understanding of complex research, cutting-edge medical interventions, and urgent health policy debates that affect patients and the clinicians who care for them. Practicing clinicians, biomedical researchers, medical trainees, patients, and anyone with an interest in health will find unique insights in “Intention to Treat.”
January 11, 2023
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NEJM This Week — January 12, 2023

Featuring articles on the progression of atrial fibrillation after cryoablation, empagliflozin in chronic kidney disease, repeat expansion in late-onset cerebellar ataxia, and the safety of inpatient health care; a review article on primary ovarian insufficiency; a case report of a man with hypokalemia and paranoia; and Perspective articles on the anchor strategy and on corporate investors in primary care. Supplement to the New England Journal of Medicine, Vol. 388, No. 2.
January 11, 2023
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NEJM This Week — January 5, 2023

Featuring articles on a monoclonal antibody for early Alzheimer’s disease, risk assessment for patients with heart failure, RAS inhibition in pancreatic cancer, inhibition of mutant KRAS in colorectal cancer, and public health and the Inflation Reduction Act; a review article on new approaches to chronic hepatitis B; a Clinical Problem-Solving on a stormy heart; and Perspective articles on the fresh assault on insurance coverage mandates, on evidence over politics, and on death by ableism. Supplement to the New England Journal of Medicine, Vol. 388, No. 1.
January 4, 2023
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To Measure is to Know

Drs. Sarah Szanton and Deidra Crews kick off Aging Fast & Slow Season 2 with guest Dr. Paris "AJ" Adkins-Jackson, Assistant Professor in the Departments of Epidemiology and Sociomedical Sciences at Columbia University Mailman School of Public Health. One big question for health researchers is how to measure structural racism in different places and systems. Dr. Adkins-Jackson is among the leading number of scientists working in this area. She joins us to discuss her research on the health impact of structural racism and to provide recommendations for how epidemiologists and other health researchers can measure structural racism, including approaches taken by other fields.  References: 1.      Adkins-Jackson PB, Incollingo Rodriguez AC. Methodological approaches for studying structural racism and its biopsychosocial impact on health. Nursing Outlook. September 2022 2.      Adkins-Jackson PB, Chantarat T, Bailey ZD, Ponce NA. Measuring Structural Racism: A Guide for Epidemiologists and Other Health Researchers. American Journal of Epidemiology. April 2022 3.      Adkins-Jackson PB, Jackson-Preston PA, Hairston T. “The only way out”: How self-care is conceptualized by Black women. Ethnicity & Health. 2022
January 3, 2023
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Using Light Therapy To Treat Certain Medical Conditions

Dr. Brian Cole explains how light therapy, sometimes called phototherapy, can be used to treat certain medical conditions such as eczema, psoriasis, or other health conditions like seasonal affective disorder.
January 3, 2023
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Festive Bonus Episode: But Our Emails!

In between mince pies and braais, Yvette and Ben answer your emails and messages - contentious and occasionally comic from all over the world of global health innovation and equity. Don’t forget to keep your questions and coming - find us on all your favorite podcast platforms and social media sites! Yvette’s and Ben’s Bucket Hats are handmade in South Africa by Pozie at https://latobyveresources-pozie.business.site
December 30, 2022
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Down South with MTV Staying Alive

Recorded in MTV Studios in South Africa at the end of November, we look back at an insanely busy year for the MTV Staying Alive Foundation in creating content to help young people to make their own decisions about their health in Africa and South Asia, and reflect on big news for its future in 2023. Ben and Yvette chat with other members of the South African Board as well as podcast regular Georgia Arnold.  Guests Stephanie Ndlovu, Co-Chair, MTV Staying Alive Foundation Monde Twala, General Manager, Paramount Africa Georgia Arnold, Senior Vice President Social Responsibility Paramount Global and Executive Director, MTV Staying Alive Foundation. https://www.mtvstayingalive.org https://paramount-africa.com https://www.paramount.com https://m.youtube.com/@TheNdlovusUncut https://latobyveresources-pozie.business.site https://www.unaids.org #mtvstayingalive #mtvshuga #shugadownsouth #pozie #southafrica #HIV #AIDS #sexualhealth #contentcreation #theNdolovusUncut 
December 30, 2022
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NEJM This Week — December 29, 2022

Featuring articles on chlorthalidone in cardiovascular events, vaccines for Zaire Ebola virus disease, haloperidol for delirium in ICU patients, and reporting of emissions to achieve net-zero health care; a review article on alcohol-associated hepatitis; a case report of a man with exertional chest discomfort; and Perspective articles on understanding the key to outbreak control, on hospitals and health equity, and on engineering for grief. Supplement to the New England Journal of Medicine, Vol. 387, No. 26.
December 28, 2022
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NEJM This Week — December 22, 2022

Featuring articles on surgery or endovascular therapy for limb ischemia, dupilumab in patients with eosinophilic esophagitis, an oral regimen for rifampin-resistant tuberculosis, gene therapy for ART-SCID, and recombinant ADAMTS13 in a pregnant woman with thrombotic thrombocytopenic purpura; a review article on oxygen delivery in the treatment of anemia; a case report of a woman with postpartum abdominal pain and fever; and Perspective articles on U.S. health insurance coverage and financing, on cholera in Haiti, again, and on revaluing primary care. Supplement to the New England Journal of Medicine, Vol. 387, No. 25.
December 21, 2022
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NEJM AI Grand Rounds

NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. You’ll learn how AI will change clinical practice and healthcare, how it will impact the patient experience, and about the people who are pushing for innovation. Whether you are an AI researcher or a practicing clinician, these conversations will enlighten and surprise you as we journey through this very exciting field. Produced by NEJM Group.
December 14, 2022
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NEJM This Week — December 15, 2022

Featuring articles on gene therapy for dystrophic epidermolysis bullosa, glofitamab in refractory diffuse large B-cell lymphoma, talquetamab for multiple myeloma, once-weekly semaglutide in adolescents with obesity, and on click chemistry; a review article on the risks of infection in xenotransplantation; a case report of a woman with fatigue and weight gain; and Perspective articles on a step toward interoperability of health IT, on a Covid-19 milestone attained, and on the Josephine way. Supplement to the New England Journal of Medicine, Vol. 387, No. 24.
December 14, 2022
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The Most Common Pickleball Injuries

In this episode, Dr. Brian Cole is joined by Brandon Abonce, PT, DPT from RUSH Physical Therapy to talk about the most common pickleball injuries.
December 13, 2022
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Welcome to Season 2: Aging Fast & Slow

Tune in as we interview cutting-edge scientists, policy experts, and innovators as we seek to understand structural discrimination, and resilience across the lifecourse and the impact on health inequities with aging. Podcast guests will speak about their research or work, ‘aha’ moments, and next topics for exploration.
December 12, 2022
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NEJM This Week — December 8, 2022

Featuring articles on therapy with tumor-infiltrating lymphocytes or ipilimumab in melanoma, biopsy method and overdiagnosis in prostate cancer, methylprednisolone for heart surgery in infants, and in utero enzyme-replacement therapy; a review article on hemochromatosis; a case report of a man with fatigue, weight loss, and pulmonary nodules; and Perspective articles on for-profit medical schools, on closing the gap in cancer genomic testing, and on deciding on her dimples. Supplement to the New England Journal of Medicine, Vol. 387, No. 23.
December 7, 2022
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2022 World AIDS Day from Tembisa, South Africa

Yvette Raphael welcomes co-host Ben Plumley to Tembisa, South Africa, for a World AIDS Day special, to reflect on the sometimes bumpy response from the country with the largest number of people living with HIV. And catch Yvette’s interview with Lolo Saliso, HIV & human rights activist from Advocates for the Prevention of HIV in Africa on how it is young people’s time to lead, building on the legacy of older “dinosaur” activists like Yvette and Ben.  https://www.unaids.org/en https://sanac.org.za https://apha.org.za #worldaidsday #HIV #southafrica #pozie #apha #hivprevention #gbv #dapvirinering #cabla
December 4, 2022
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NEJM This Week — December 1, 2022

Featuring articles on RAS inhibition in advanced chronic kidney disease, buprenorphine versus methadone in pregnancy, iron chelation for Parkinson’s disease, training to prevent crashes in teens with ADHD, and on prolonging cellular life after hypoxic death; a review article on infantile and childhood hydrocephalus; a Clinical Problem-Solving on hiding in plain sight; and Perspective articles on the perpetual challenge of infectious diseases, on prescribing opioids for pain, on the White House Conference on Hunger, Nutrition, and Health, and on injustice disorder. Supplement to the New England Journal of Medicine, Vol. 387, No. 22.
November 30, 2022
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NEJM This Week — November 24, 2022

Featuring articles on pemafibrate to reduce cardiovascular risk, on lifting universal masking in schools, defibrillation strategies for refractory ventricular fibrillation, bepirovirsen in chronic hepatitis B infection, and the IARC perspective on oral cancer prevention; a review article on climate change and vectorborne diseases; a case report of a woman with decreased vision and headache; and Perspective articles on privacy and security, on protecting care for all, and on transgender health and science denialism. Supplement to the New England Journal of Medicine, Vol. 387, No. 21.
November 23, 2022
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NEJM This Week — November 17, 2022

Featuring articles on a monoclonal antibody against malaria in Mali, assessing strategies for spontaneous-breathing trials, lipoprotein(a) and cardiovascular disease, and the Covid-19 vaccine in children and adolescents in Qatar; a review article on gout; a case report of a man with progressive dyspnea, neck swelling, and a lung mass; and Perspective articles on telemedicine, on monkeypox, and on COP27 and urgent action needed for Africa and the world. Supplement to the New England Journal of Medicine, Vol. 387, No. 20.
November 16, 2022
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Sharing the Mic Ep05 – Pandemics Preparation For Whom?

We are sharing the mic with Frontline AIDS again, looking at recent global health diplomacy efforts in pandemics preparation and response - and how communities have been finagling and fighting for a seat at the table, to ask the question - pandemics preparation and responses for whom? Joining Ben Plumley are Lois Chingandu, Director of Evidence and Influence Frontline AIDS Christian Acosta, Coordinator of the HIV-FM Project for Frontline AIDS partner Kimirina (Ecuador) RD Marte, Executive Director of APCASO (Thailand) https://frontlineaids.org https://www.kimirina.org https://apcaso.org https://www.ashotinthearmpodcast.com #pandemics #pppr #worldhealthsummit #G20 #GFATM #globalfund #communityleadership #HIV #AIDS #COVID #pandemicsthreats #vaccinequity #peoplesvaccine #diagnostics #fightforwhatcounts
November 15, 2022
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Current & Future Pandemics – How Resilient are we?

Ben is joined by two giants of global health diplomacy, Ambassadors Mark Dybul and Eric Goosby, to take stock of how resilient the world is in sustaining existing infectious disease responses and preparing for future pandemic threats, by building on existing infrastructure - particularly optimized lab-based diagnostic networks. A Shot In the Arm Podcast is a member of the Health Podcast Network, and is a project of the Global Health Reporting Center. This episode is brought to you with the kind support of Roche Diagnostics.  Guests Ambassador Mark Dybul, Co-Director of the Center for Global Health Practice and Impact and Professor in the Department of Medicine at Georgetown University Ambassador Eric Goosby, Professor of Medicine and Director of Global Health Delivery and Diplomacy, Institute for Global Health Sciences, UCSF. https://cghpi.georgetown.edu https://globalhealthsciences.ucsf.edu https://theindependentpanel.org https://www.state.gov/pepfar https://www.theglobalfund.org/en https://cop27.eg #pandemics #HIV #AIDS #TB #Malaria #COVID #climatecrisis #onehealth #COP27 #WHO #UNAIDS #GlobalFund #PEPFAR #Diagnostics #Vaccines #Treatments #Laboratories #PointOfCare #Monitoring #Infectiousdisease #globalhealthdiplomacy #resilience
November 12, 2022
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Nashville’s Opportunity: Eco-Action or Anxiety In this excerpt from a Climate x Health Twitter Spaces live chat, experts from Vanderbilt, Oak Ridge National Laboratory, and others discuss hope and want listeners to be energetic and reject “doomerism” while embracing reality and emphasizing teamwork without ego to accomplish individual and systemic goals. This conversation was hosted live from the AAMC conference in Nashville.