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Clinical Research and Drug Discovery Podcasts

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Latest Episodes

NEJM This Week — October 22, 2020

Featuring articles on dasatinib–blinatumomab in Ph-positive ALL, an anti–Siglec-8 antibody in gastritis and duodenitis, inhaled molgramostim therapy in autoimmune pulmonary alveolar proteinosis, treating Middle East Respiratory Syndrome, fibroblasts in rheumatoid arthritis, and how can we bridge the partisan divide and conquer Covid; a review article on sensory ganglionopathy; a case report of a man with abdominal pain, joint swelling, and skin lesions; and Perspective articles on whether the elections can end the health reform stalemate, on insurance coverage after job loss, on redoubling efforts to help Americans quit smoking, and on taking back our voices. Supplement to the New England Journal of Medicine, Vol. 383, No. 17.
October 21, 2020
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NEJM This Week — October 15, 2020

Featuring articles on upadacitinib or abatacept in rheumatoid arthritis, a nimble GWAS on Covid-19, life expectancy after bariatric surgery, an mRNA–based Covid-19 vaccine in nonhuman primates, and selection against pathogenic mitochondrial DNA; a review article on autophagy in human diseases; a case report of a man with confusion, fatigue, and garbled speech; and Perspective articles on health policy in a Biden administration or after a Trump election victory, on Covid-19 and the mandate to redefine preventive care, and on when all you have is quality of life. Supplement to the New England Journal of Medicine, Vol. 383, No. 16.
October 14, 2020
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NEJM This Week — October 8, 2020

Featuring articles on empagliflozin in heart failure, cardiovascular outcomes with ertugliflozin in diabetes, dapagliflozin in chronic kidney disease, single or dual antiplatelet treatment after TAVI, on dying in a leadership vacuum, Covid-19 and implications for the health care system, and mending mitochondrial mutation; a review article on secondary mitral regurgitation; a case report of a man with lymphoma and abdominal pain; and Perspective articles on the role of market forces in U.S. health care, on embracing antiracism in medicine, and on improving clinical trial enrollment. Supplement to the New England Journal of Medicine, Vol. 383, No. 15.
October 7, 2020
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NEJM This Week — October 1, 2020

Featuring articles on early rhythm-control therapy for atrial fibrillation, evolocumab in heterozygous pediatric familial hypercholesterolemia, atezolizumab in non–small-cell lung cancer, HPV vaccination and the risk of cervical cancer, and physician work hours and the gender pay gap; a review article on myelodysplastic syndromes; a Clinical Problem-Solving describing parroting lymphoma; and Perspective articles on health in aging, on ensuring uptake of vaccines against SARS-CoV-2, on an innovative approach to reducing gun suicides, and on the ritual of the table. Supplement to the New England Journal of Medicine, Vol. 383, No. 14.
September 30, 2020
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NEJM This Week — September 24, 2020

Featuring articles on a RAS oncogene inhibitor at last, avelumab maintenance therapy in bladder cancer, lower-dose zinc for childhood diarrhea, antisense oligonucleotides for hereditary angioedema, and sussing out the sestrins; a review article on congenital adrenal hyperplasia due to 21-hydroxylase deficiency; a case report of a man with sudden cardiac arrest; and Perspective articles on competing visions for the future of health policy, on assessing the safety of glucose-lowering drugs, on Ebola response priorities in the time of Covid-19, and on a farewell gift from a mother. Supplement to the New England Journal of Medicine, Vol. 383, No. 13.
September 23, 2020
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NEJM This Week — September 17, 2020

Featuring articles on exome sequencing analysis in stillbirth, a two-year trial of belimumab in lupus nephritis, nocturnal oxygen in COPD, adjuvant targeted therapy in melanoma, and daratumumab in refractory lupus; a review article on immune tolerance; a case report of a man with fever and shortness of breath after liver transplantation; and Perspective articles on consent to trainee involvement in pediatric care, on examining examinations conducted under anesthesia, on June Medical Services v. Russo, and on sticks and stones. Supplement to the New England Journal of Medicine, Vol. 383, No. 12.
September 16, 2020
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NEJM This Week — September 10, 2020

Featuring articles on strategies for tracheostomy decannulation, extending factor VIII activity in hemophilia A, eflornithine–sulindac in familial adenomatous polyposis, darolutamide in castration-resistant prostate cancer, the NIH RADx initiative, and on training innate immunity; a review article on pharmacologic treatment of ADHD; a case report of a man with intrusive thoughts and fear of poisoning; and Perspective articles on health equity, on the cancer risk associated with lorcaserin, on whether Covid can catalyze an educational transformation, and on the ideal intern. Supplement to the New England Journal of Medicine, Vol. 383, No. 11.
September 9, 2020
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NEJM This Week — September 3, 2020

Featuring articles on weight loss in underserved patients, the effect of phenylbutyrate–taurursodiol on ALS progression, tepotinib in lung cancer, capmatinib in MET-altered lung cancer, and reopening primary schools during the pandemic; a review article on pulmonary fibrotic diseases; a Clinical Problem-Solving describing a curve ball; and Perspective articles on progress in cancer research, prevention, and care; on public health decision making during Covid-19; on long-term care policy after Covid-19; and on the tragedy of measles. Supplement to the New England Journal of Medicine, Vol. 383, No. 10.
September 2, 2020
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NEJM This Week — August 27, 2020

Featuring articles on selpercatinib in RET fusion–positive lung cancer, selpercatinib for medullary thyroid cancer, a closed-loop system in children with type 1 diabetes, sticky findings in breast cancer, and reconsidering the use of race correction in clinical algorithms; a review article on atherosclerotic plaque healing; a case report of a woman with headache and gait imbalance; and Perspective articles on improving the quality of U.S. health care, on Covid-19 and immunity in aging populations, and on U.S. efforts to curb antibiotic resistance. Supplement to the New England Journal of Medicine, Vol. 383, No. 9.
August 26, 2020
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NEJM This Week — August 20, 2020

Featuring articles on evinacumab for familial hypercholesterolemia, the effects of diet vs. gastric bypass in diabetes, drug-coated balloons for dysfunctional dialysis arteriovenous fistulas, fracture risk vs. fracture prevention with bisphosphonates, and the challenges of “return to work” in an ongoing pandemic; a review article on trigeminal neuralgia; a case report of a woman with altered mental status and weakness on the left side; and Perspective articles on low-threshold buprenorphine initiation, on when prescribing isn’t enough, on the death throes of Mercy, and on when the EMR stole a doctor’s pen. Supplement to the New England Journal of Medicine, Vol. 383, No. 8.
August 19, 2020
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NEJM This Week — August 13, 2020

Featuring articles on azacitidine plus venetoclax in AML, compression for recurrent cellulitis of the leg, decreased population-based mortality from lung cancer, the United States and the WHO, the need for a tighter particulate-matter air-quality standard, and bilirubin in IBD and pancreatitis; a review article on epigenetic therapies for cancer; a case report of a woman with a lung mass; and Perspective articles on whether we spend too much on health care, on people with hepatitis C who inject drugs, on hepatitis C treatment in correctional facilities, and on a national medical response to crisis. Supplement to the New England Journal of Medicine, Vol. 383, No. 7.
August 12, 2020
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NEJM This Week — August 6, 2020

Featuring articles on hydroxychloroquine for Covid-19 prophylaxis, subcutaneous or transvenous ICD therapy, Zika virus disease in Colombia, ofatumumab vs. teriflunomide in multiple sclerosis, and spending after state specialty-drug out-of-pocket caps; a review article on native-valve infective endocarditis; a Clinical Problem-Solving on being led astray; and Perspective articles on the National Academy of Medicine and the quality of health care, on care churn, on mental health and the Covid-19 pandemic, and on preventing a parallel pandemic. Supplement to the New England Journal of Medicine, Vol. 383, No. 6.
August 5, 2020
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NEJM This Week — July 30, 2020

Featuring articles on nirsevimab for the prevention of RSV disease, RSV vaccination during pregnancy to protect infants, uterine-artery embolization or myomectomy for uterine fibroids, a trial of a therapeutic anti–yellow fever virus antibody, and a bad acid trip for sarcomas; a review article on chronic lymphocytic leukemia; a case report of a woman with chest pain, dyspnea, and shock; and Perspective articles on health care as an ongoing policy project, on Covid’s color line, and on the illusion of inclusion. Supplement to the New England Journal of Medicine, Vol. 383, No. 5.
July 29, 2020
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S2: E05: Dr. Amy Abernethy on the Role of Technology Within the Biomedical Landscape

Hear how Dr. Amy Abernethy, Principle Deputy Commissioner and current Acting CIO of the FDA sees the role of technology, including AI and RWE in the drug development landscape. Fireside chat featuring: - Dr. Amy Abernethy, the Principle Deputy Commissioner and current Acting CIO of the FDA - Dr Amir Kalali, Chief Curator of CNS Summit Learn more about CNS Summit and to read full bios on each speaker, head to CNSSummit.org. Follow us on Twitter (@cnssummit). Hear and subscribe to all the episodes in this series on Health Podcast Network.
July 28, 2020
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S2: E04: Ali Parsa of Babylon Health on Affordable and Accessible Healthcare

Hear how Ali Parsa, CEO of Babylon Health sees the future of enabling accessible and affordable health service to every person on earth using quantum computing, 5G networks, IoT, prescriptive analytics, augmented reality and robotics. This episode was recorded on the main stage at the 2019 CNS Summit in Boca Raton, Florida. Panel discussion featuring: - Ali Parsa, CEO of Babylon Health - Dr Amir Kalali, Chief Curator of CNS Summit - Dr Junaid Bajwa, Global Lead for Strategic Alliances and Solutions for the Global Digital Centre of Excellence at Merck Learn more about CNS Summit and to read full bios on each speaker, head to CNSSummit.org. Follow us on Twitter (@cnssummit). Hear and subscribe to all the episodes in this series on Health Podcast Network.
July 21, 2020
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S2: E03: Jessica Mega of Verily on Life Sciences and Technology

Hear how Jessica Mega, Chief Medical and Scientific Officer at Verily, sees the intersection of life science, healthcare and technology through research programs, such as Project Baseline. Panel Conversation featuring: - Jessica Mega, Chief Medical and Scientific Officer at Verily - Dr. Reed Tuckson, Managing Director of Tuckson Health Connections - Dr Amir Kalali, Chief Curator of CNS Summit Learn more about CNS Summit and to read full bios on each speaker, head to CNSSummit.org. Follow us on Twitter (@cnssummit). Hear and subscribe to all the episodes in this series on Health Podcast Network.
July 13, 2020
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S2: E02: MIT Professor, Dina Katabi on Wearables to Invisibles

Hear how MIT Professor Dina Katabi sees the future of neurodegenerative diseases like Parkinson's and Huntington's, mood disorders and GI and Immune system diseases with applications like wearables and AI. Fireside Chat Featuring: - Dina Katabi, Andrew & Erna Viterbi Professor of Electrical Engineering and Computer Science at MIT - Dr Amir Kalali, Chief Curator of CNS Summit This was recorded on the main stage at the 2019 CNS Summit which was held in Boca Raton, Florida. To learn more about CNS Summit and read full bios on each speaker, head to CNSSummit.org. Follow us on Twitter @cnssummit. Hear and subscribe to all the episodes in this series on Health Podcast Network.
July 7, 2020
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S2: E01: Innovations in Psychedelics for Mental Healthcare with George Goldsmith and Ekaterina Malievskaia

Hear how George Goldsmith and Ekaterina Malievskaia from COMPASS Pathways are working to bring innovation psychedelic drug applications for depression. Learn what what this means for patients, regulators and trials. Panel Conversation Featuring: - George Goldsmith Co-Founder and Executive Chairman of COMPASS Pathways - Dr Ekaterina Malievskaia, Research and Development at COMPASS - Jane Metcalf, Founder of Neo.Life - Dr Amir Kalali, Chief Curator of CNS Summit This was recorded on the main stage at the 2019 CNS Summit which was held in Boca Raton, Florida. To learn more about CNS Summit and read full bios on each speaker, head to CNSSummit.org. Follow us on Twitter (@cnssummit). Hear and subscribe to all the episodes in this series on Health Podcast Network.
June 30, 2020
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Bonus: CNS Summit Call on the Impact of COVID-19 Crisis on Clinical Trials

This is a special episode of a webinar that was recorded on Friday, May 8, 2020. In this recording, we hear from Dr. Amy Abernethy, Principal Deputy Commissioner and Acting CIO of the FDA, as she speaks with Dr Amir Kalali, Chief Curator of CNS Summit. Drs. Abernethy and Kalali discuss: How Covid-19 is impacting drug development How the FDA is aligning and responding to the pandemic Unexpected ways the pandemic may influence clinical research and medicine For more podcasts like this, be sure to subscribe to the CNS Summit Podcast on Apple Podcasts, Google Podcasts or Spotify, and you can also find us on Health Podcast Network at HealthPodcastNetwork.com Learn more about the CNS Summit and follow us on Twitter (@cnssummit) to find out more about upcoming events, news and announcements.
June 3, 2020
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S1: E3: Eric Perkaslis on research, informatics, technology

Eric is currently Chief Science Officer at Datavant and Visiting Scientist at the Department of Biomedical Informatics at Harvard Medical School. Most recently, Eric was Senior Vice President Data Sciences at Takeda R&D. Previously, Eric was the Executive Director of the Center for Biomedical Informatics and the Countway Library of Medicine at Harvard Medical School. Eric served as the CIO and Chief Scientist (Informatics) at the U.S. Food and Drug Administration. Eric has also served as Senior Bioinformatics Advisor at Precision for Medicine, as the Chair of the ASCO CancerLinQ technology advisory and on the Editorial Board of the DIA flagship journal, Journal of Regulatory Science and Innnovation Prior to FDA, Eric was Senior Vice President of R&D IT at J&J Pharmaceuticals R&D. Eric also held the posts of Vice President R&D Informatics, Vice President and CIO, Director of Research IT, Assistant Director and Director of Drug Discovery Research at J&J. Eric has a PhD in chemical and biochemical engineering from Drexel University. Learn more about the CNS Summit and follow us on Twitter (@cnssummit). Listen to this episode on Health Podcast Network.
October 31, 2019
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S1: E2: A conversation with Deborah Dunsire, CEO and President of Lundbeck

Deborah Dunsire is the CEO and President of Lundbeck. Prior to that, she was the CEO and President of FORUM Pharmaceuticals and the CEO and President at Millennium Pharmaceuticals. She has more than 25 years of scientific, clinical, operational and commercial experience, and proven leadership in the biological and pharmaceutical industry. Dr. Dunsire holds a Doctor of Medicine from the University of Witwatersand, Johannesburg, South Africa. Learn more about the CNS Summit and follow us on Twitter (@cnssummit). Listen to this episode on Health Podcast Network.
October 31, 2019
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S1: E1: Insights from Vivek Ramaswamy, founder and CEO, Roivant Sciences

Vivek Ramaswamy is the founder and CEO of Roivant Sciences, the parent of a growing family of companies focused on diverse areas including women’s health, rare diseases, neurology, cardiometabolic diseases, urology, dermatology, RNA therapeutics, and healthcare data.  Learn more about the CNS Summit and follow us on Twitter (@cnssummit). Listen to this episode on Health Podcast Network.
October 30, 2019
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Welcome! Introducing the CNS Summit Podcast

Hi everyone this is Amir Kalali. I am a physician researcher focused on the intersection of life sciences and technology. Welcome to the CNS Summit podcasts, a new series of podcasts created in partnership with the Health Podcast Network and Mission Based Media.  This new series is designed to share the insights and information shared by leaders at the CNS Summit. CNS Summit was founded by life science leaders in 2009 and has developed into a global community of leaders who are passionate about shaping the future, with a focus on collaboration, innovation, and technology.  Our mission is to have a positive impact on the success of clinical development programs. We believe this mission is our ethical duty to the patients we serve by developing new treatments. If this mission resonates with you, and you would like to be surrounded by creative, passionate, and future-focused colleagues, join us. In this series, we’ll bring you a selection keynotes and conversations featuring some of the most interesting speakers in the industry. You can learn more about CNS Summit by visiting cnssummit.org.   You can also find all the episodes of the CNS Summit podcast there on our website, as well as the Health Podcast Network. From there, you can stream or download the podcasts that matter most to you. Once again, welcome to the CNS Summit podcast, and I look forward to the opportunity of meeting many of you soon.
October 22, 2019
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