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Clinical Research and Drug Discovery Podcasts

Clinical Research Podcasts

Latest Episodes

NEJM This Week — September 16, 2021

Featuring articles on salt substitution and cardiovascular events, safety of the BNT162b2 mRNA Covid-19 vaccine, lutetium-177 in prostate cancer, typhoid vaccine in Malawian children, and a call for emergency action on the climate crisis; a review article on the treatment of acute appendicitis; a case report of a woman with Covid-19 and suicidal ideation; and Perspective articles on public option plans and on the treatment of older adults with cancer. Supplement to the New England Journal of Medicine, Vol. 385, No. 12.
September 15, 2021
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NEJM This Week — September 9, 2021

Featuring articles on a trial of mobile stroke units, iron interventions in infants in rural Bangladesh, somatic mutations in sporadic cerebral cavernous malformations, malaria vaccination with or without chemoprevention, and sensible but very cool advances in protein chemistry; a review article on the challenges of sarcoidosis and its management; a case report of an adolescent seeking HIV prophylaxis; and Perspective articles on SARS-CoV-2 human challenge studies, on supporting value-based health care, and on environmental racism and climate change. Supplement to the New England Journal of Medicine, Vol. 385, No. 11.
September 8, 2021
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NEJM This Week — September 2, 2021

Featuring articles on the inactivated SARS-CoV-2 vaccine in Chile, mycophenolate mofetil for immune thrombocytopenia, cardiovascular and renal outcomes with efpeglenatide, MRI-directed prostate biopsies, and natural killer cells in defense against HPV; a review article on chronic meningitis; a Clinical Problem-Solving describing inadequate support; and Perspective articles on population health and human rights, on Covid-induced changes in health care delivery, and on paying for digital health care. Supplement to the New England Journal of Medicine, Vol. 385, No. 10.
September 1, 2021
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NEJM This Week — August 26, 2021

Featuring articles on therapeutic anticoagulation in hospitalized patients with Covid-19, anticoagulation in moderate Covid-19, a monoclonal antibody for malaria prevention, triple therapy for cystic fibrosis, modeling heart development, and remembering past lessons about structural racism; a review article on heparin resistance; a case report of a man with relapsed acute myeloid leukemia; and Perspective articles on revisiting the FDA approval of aducanumab, on controversy and progress in Alzheimer’s disease, and on a pink salwar. Supplement to the New England Journal of Medicine, Vol. 385, No. 9.
August 25, 2021
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NEJM This Week — August 19, 2021

Featuring articles on adjuvant pembrolizumab in renal-cell carcinoma, oral atogepant for migraine prevention, male infertility and small noncoding RNAs, and adjunct immune globulin for vaccine-induced thrombotic thrombocytopenia; a review article on long-term survival after kidney transplantation; a case report of a man with fatigue and leg swelling; and Perspective articles on ending the campaign to undo the ACA in the courts, on Medicare Physician Payment Reform, and on the Covid-19 infodemic. Supplement to the New England Journal of Medicine, Vol. 385, No. 8.
August 18, 2021
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NEJM This Week — August 12, 2021

Featuring articles on vaccine effectiveness against the delta Covid-19 variant, injectable cabotegravir for prevention of HIV infection, antibody to factor XI after total knee replacement, year 1 of the Bundled Payments for Care Improvement–Advanced payment model, and on a new dimension in the RNA world; a review article on signature cytokines and immune-mediated inflammatory diseases; a case report of a woman with fever, sore throat, and confusion; and Perspective articles on confronting long-haul Covid, on the criminalization of gender-affirming care, and on when low tech wins. Supplement to the New England Journal of Medicine, Vol. 385, No. 7.
August 11, 2021
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NEJM This Week — August 5, 2021

Featuring articles on CRISPR-Cas9 disruption of TTR in transthyretin amyloidosis, tirzepatide versus semaglutide for type 2 diabetes, milrinone or dobutamine for cardiogenic shock, decompression versus fusion for lumbar spondylolisthesis, and SARS-CoV-2 and immunosuppression; a review article on age-related macular degeneration; a Clinical Problem-Solving on turning purple with pain; and Perspective articles on the complementarity of public health and medicine, on contact tracing for Covid-19, on supporting trainees from groups that are underrepresented in medicine, and on establishing medical civil rights. Supplement to the New England Journal of Medicine, Vol. 385, No. 6.
August 4, 2021
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NEJM This Week — July 29, 2021

Featuring articles on the duration of adjuvant therapy in breast cancer, tofacitinib for Covid-19 pneumonia, complications in youth-onset type 2 diabetes, a small-molecule SMN2 modifier in type 1 spinal muscular atrophy, a hyperimmune globulin to prevent congenital cytomegalovirus, and scarless wound healing; a review article on depression in adolescents; a case report of a woman with bloody stools and thrombocytopenia; and Perspective articles on from crime to care, on health care budgets for rural providers, on identifying and tracking SARS-CoV-2 variants, and on a child’s loss. Supplement to the New England Journal of Medicine, Vol. 385, No. 5.
July 28, 2021
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NEJM This Week — July 22, 2021

Featuring articles on PCI guided by FFR or angiography for STEMI, pimavanserin for dementia-associated psychosis, Covid-19 prevention and attenuation with mRNA vaccines, second-line treatment of HIV-1 infection in Sub-Saharan Africa, and racial inequality in prescription opioid receipt; a review article on substance use among men who have sex with men; a case report of a woman with cognitive impairment, headache, and memory loss; and Perspective articles on medical–financial partnerships, on Virchow at 200 and Lown at 100, and on one hundred years of insulin for some. Supplement to the New England Journal of Medicine, Vol. 385, No. 4.
July 21, 2021
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NEJM This Week — July 15, 2021

Featuring articles on rehabilitation after hospitalization for heart failure, detecting speech in a paralyzed person with anarthria, ruxolitinib for chronic graft-versus-host disease, BNT162b2 vaccination against Covid-19 in 12-to-15-year-old adolescents, and inhibiting PD-L1 in hepatocellular carcinoma; a review article on the initial management of seizure in adults; a case report of a pregnant woman with fever, abdominal pain, and headache; and Perspective articles on averting future vaccine inequity, on scaling up Covid-19 vaccination in Africa, and on a medical home. Supplement to the New England Journal of Medicine, Vol. 385, No. 3.
July 14, 2021
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NEJM This Week — July 8, 2021

Featuring articles on fetal surgery for severe left diaphragmatic hernia and for moderate left diaphragmatic hernia, comparisons of interleukin-17 inhibitors in psoriasis, and SARS-CoV-2 variants and vaccines; a review article on hematuria in adults; a case report of a man with ataxia; and Perspective articles on addressing vaccine hesitancy in BIPOC communities, on Covid-19 vaccine follow-through, and on the CT scan after 50 years. Supplement to the New England Journal of Medicine, Vol. 385, No. 2.
July 7, 2021
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NEJM This Week — July 1, 2021

Featuring articles on the treatment of multisystem inflammatory syndrome in children, a transglutaminase 2 inhibitor for celiac disease, daratumumab in light-chain amyloidosis, embryo selection in vitro, and clonal peregrinations in the placenta; a review article on cerebral venous thrombosis; a Clinical Problem-Solving on a brewing back pain; and Perspective articles on the learning health system, on whether learning is worth the trouble, and on Covid-19 and the investigator pipeline. Supplement to the New England Journal of Medicine, Vol. 385, No. 1.
June 30, 2021
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NEJM This Week — June 24, 2021

We discuss the latest in medical research and ideas.
June 23, 2021
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NEJM This Week — June 17, 2021

Featuring articles on mRNA Covid-19 vaccine safety in pregnant persons, hypothermia or normothermia after cardiac arrest, rituximab vs. mycophenolate mofetil for pemphigus, sudden cardiac death in persons with HIV, and SARS-CoV-2 vaccine design; a review article on infections in patients with cirrhosis; a case report of a man with cough, fever, and shortness of breath; and Perspective articles on promoting equity for women in medicine, on misogyny in medicine, and on escaping the labyrinth. Supplement to the New England Journal of Medicine, Vol. 384, No. 24.
June 16, 2021
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NEJM This Week — June 10, 2021

Featuring articles on wolbachia-infected mosquito deployments for dengue, Ad26.COV2.S vaccine efficacy against Covid-19, thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination, variant SARS-CoV-2 infection after vaccination, and on diabetes treatment and control in U.S. adults from 1999 to 2018; a review article on recent advances in the treatment of melanoma; a case report of a woman with pain, swelling, and ecchymosis of the left arm; and Perspective articles on HIPAA at 25, on HIPAA and the leak of “deidentified” EHR data, and on what did I sign up for? Supplement to the New England Journal of Medicine, Vol. 384, No. 23.
June 9, 2021
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NEJM This Week — June 3, 2021

Featuring articles on left atrial appendage occlusion during cardiac surgery, thrombosis after ChAdOx1 nCoV-19 vaccination, adjuvant nivolumab for invasive urothelial carcinoma, a meningococcal X vaccine in Mali, and irritable bowel syndrome and immunity; a review article on HIV infection; a Clinical Problem-Solving describing a hypertensive heartbreak; and Perspective articles on women’s health; on institutional problems, individual solutions; and on merging mortalities. Supplement to the New England Journal of Medicine, Vol. 384, No. 22.
June 2, 2021
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NEJM This Week — May 27, 2021

Featuring articles on aspirin dosing in cardiovascular disease, antibiotic therapy for prosthetic joint infection, gene therapy for adenosine deaminase deficiency, a novel microRNA in acute myocarditis, and immediate “kangaroo mother care” of low-birth-weight infants; a review article on somatic mutations in “benign” disease; a case report of a woman with abdominal pain and aortic dilatation; and Perspective articles on the “legal epidemiology” of pandemic control, on a hidden opportunity, and on dilemmas of double consciousness. Supplement to the New England Journal of Medicine, Vol. 384, No. 21.
May 26, 2021
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NEJM This Week — May 20, 2021

Featuring articles on efficacy of the ChAdOx1 nCoV-19 vaccine against the B.1.351 variant, NVX-CoV2373 vaccine efficacy against B.1.351 in South Africa, endovascular therapy for basilar-artery stroke, intensive or standard blood-pressure control, and on gene editing for congenital neutropenia; a review article on monoclonal gammopathy of renal significance; a case report of a woman with nausea, diarrhea, and acute kidney failure; and Perspective articles on minority tax reform, on training future health justice leaders, and on finding a way to break through the fog. Supplement to the New England Journal of Medicine, Vol. 384, No. 20.
May 19, 2021
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NEJM This Week — May 13, 2021

We discuss the latest in medical research and ideas.
May 12, 2021
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NEJM This Week — May 6, 2021

Featuring articles on a trial of an antibody to amyloid in Alzheimer’s disease, short-course treatment of tuberculosis, weight loss maintenance with exercise and liraglutide, dexamethasone and surgical-site infection, a fountain of youthful retinal ganglion cells, and decoupling crisis response from policing; a review article on gastric emptying abnormalities in diabetes; a Clinical Problem-Solving on the inside and out; and Perspective articles on understanding and mitigating health inequities, on designing an independent public health agency, and on losing touch. Supplement to the New England Journal of Medicine, Vol. 384, No. 18.
May 5, 2021
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NEJM This Week — April 29, 2021

Featuring articles on vadadustat in non–dialysis-dependent chronic kidney disease, vadadustat for anemia in patients undergoing dialysis, oncolytic HSV therapy in pediatric glioma, blood-loss prevention after cesarean delivery, and diversity of the national medical student body; a review article on postpartum hemorrhage; a case report of a newborn girl with a neck mass; and Perspective articles on Australian firearm regulation at 25, on vaccination plus decarceration, and on the Zoom family meeting. Supplement to the New England Journal of Medicine, Vol. 384, No. 17.
April 28, 2021
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NEJM This Week — April 22, 2021

Featuring articles on interleukin-6 receptor blockade in severe Covid-19, tocilizumab in severe Covid-19 pneumonia, a microbiota-directed food supplement for malnutrition, sacituzumab govitecan in triple-negative breast cancer, and fighting SARS-CoV-2 with nanobodies; a review article on adrenal incidentaloma; a case report of a man with a rash on the scalp and face; and Perspective articles on advancing President Biden’s equity agenda, on encouraging acceptance of Covid-19 vaccines, and on Nanima. Supplement to the New England Journal of Medicine, Vol. 384, No. 16.
April 21, 2021
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NEJM This Week — April 15, 2021

Featuring articles on hypothermic machine perfusion in liver transplantation, a trial of psilocybin for depression, the effectiveness of the BNT162b2 mRNA vaccine in Israel, sedation in mechanically ventilated adults with sepsis, and soothing science skepticism; a review article on glomerular filtration and albuminuria; a case report of a woman with fever, flank pain, and inguinal lymphadenopathy; and Perspective articles on new legislation on out-of-network billing, on remote patient monitoring, and on remembering the Freedom House Ambulance Service. Supplement to the New England Journal of Medicine, Vol. 384, No. 15.
April 14, 2021
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NEJM This Week — April 8, 2021

Featuring articles on lenvatinib plus pembrolizumab in renal cell cancer, oxygenation targets for acute respiratory failure, cardiovascular risk and glycemic index, sutimlimab in cold agglutinin disease, extending life span in a mouse model of progeria, and overcoming Covid vaccine hesitancy; a review article on vestibular schwannomas; a case report of a man with depressed mood, unsteady gait, and urinary incontinence; and Perspective articles on combatting vaccine nationalism, on vancomycin infusion reaction, and on minds in crisis in a city in crisis. Supplement to the New England Journal of Medicine, Vol. 384, No. 14.
April 7, 2021
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