Clinical Research and Drug Discovery Podcasts

Jeff Sturchio catches up with friend of the pod, Dr. Meg Doherty, WHO’s Director of HIV, Hepatitis and Sexually Transmitted Diseases. It has been a busy week at the Munich AIDS Conference for the World Health Organization, and Jeff gets Meg to unpack their conference program, particularly the release global data on HIV, viral hepatitis and STIs. 

With the #PUTPEOPLEFIRST being the call to action here at the International Aids Society Conference 2024, youth advocate Sinentlantla Gogela catches up with Y-isha Raphael about the work she has been doing at the conference, her views on the current state of youth activism and advocacy.  Sinentlantla Gogela is one of the current APHA CHAMPIONS based in South Africa, passionate about uplifting her community, keeping young girls period positive and taking all the haters to task be it in meeting rooms or on social media. She is a student at UWC pursuing her BA in physiotherapy and psychology and hoping to use that education to further her community work and advocacy. Together they delve into the complexities of young African people taking on these big issues, keeping up with their mental health and standing up for their peers.

Ben talks with Hatice Beton and Alan Donnelly about why the G20 established a new partnership on Health & Development in 2018, just prior to the COVID-19 pandemic, and how the era of pandemics is radically transforming high-level political fora like this. Guests: Alan Donnelly - Executive Chairman Sovereign Sustainability And Development & Convenor of The G20 Health And Development Partnership Hatice Beton - Executive Director, G20 Health And Development Partnership Links: https://g20healthpartnership.com

Jeff and Ben sit down with Heidi Larson from the Global Listening Project, reflecting on how the HIV movement influenced pandemic preparedness.

Yvette and Ben meet Gilead’s Dr. Moupali Das to discuss the latest clinical trial results for a new prevention technology that reduces HIV transmission by 100 percent in women. How did the research go and what plans does the company have to provide for the 100s of thousands of girls and women in need across Africa?

Featuring articles on treatments for metabolic dysfunction–associated steatohepatitis, blinatumomab in adults with ALL, and sotorasib for KRAS G12C–driven vascular malformations; a review article on HIV-associated tuberculosis; a case report of a woman with rapidly progressive dementia; and Perspectives on the abandonment of people subjected to sexual and intimate partner violence, on multicancer early detection tests, and on coping in the setting of serious illness.

The first full day of #aids2024, sees Ben and Jeff reflecting on the some powerful presentations from the opening plenary - all while Yvette is off chairing sessions of her own. Then friend of the pod, Emily Bass joins Ben and Jeff to discuss the perilous state of the largest funder of HIV services - the US tax payer, through the President’s Emergency Plan for AIDS Relief.  https://www.iasociety.org/conferences/aids2024 https://www.unaids.org/en https://www.state.gov/pepfar-aids-2024 https://thinkglobalhealth.org https://phc.org.ua/en https://www.tht.org.uk #aids2024 #HIV #diagnostics #treatment #Prevention #PrEP #ARVs #bipartisan #pepfar #protest #puttingpeoplefirst

In the first episode from #aids2024, Yvette Raphael and Jeff Sturchio join Ben to highlight the scientific data they are excited about that will be presented this week, and take stock of the panoply of pre-conferences, satellite symposia and press conferences they’ve already been to - and the conference hasn’t even started! https://www.iasociety.org/conferences/aids2024 https://www.unaids.org/en https://www.who.int/news-room/events/detail/2024/07/20/default-calendar/who-at-aids-2024 https://www.state.gov/pepfar-aids-2024 #aids2024 #HIV #diagnostics #treatment #Prevention #PrEP #ARVs #longacting #cabotegravir #lenacapavir #doxy-prep #doxy-pep #choicemanifesto

2024-07-19 Hosts Jane Myles and Angela Radcliffe were joined by Alicia C. Staley from Medidata Solutions for a fabulous conversation about her whitepaper on Medidata's Patient Centricity by Design (PCbD) process and the work they are doing to accommodate the perspectives and preferences of patients and caregivers.You can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.

We’ll be at AIDS2024 podcasting daily, and to give us a primer on what to expect, Ben is joined by infectious disease specialist, Ben LaBrot - on everything from the difference between epidemic control and elimination to how to get prevention and care services to communities hardly reached by conventional clinical services. This podcast is supported by Roche Molecular Diagnostics. https://www.iasociety.org/conferences/aids2024 https://keck.usc.edu https://diagnostics.roche.com/gb/en/home.html https://floatingdoctors.com https://www.unaids.org/en #aids2024 #HIV #AIDS #epidemiccontrol #elimination #marginalisedpopulations #PrEP #treatment #diagnostics

Featuring articles on tenecteplase for ischemic stroke within 4.5 to 24 hours after the stroke, risankizumab vs. ustekinumab for Crohn’s disease, nirmatrelvir–ritonavir as Covid-19 postexposure prophylaxis, and efanesoctocog alfa in children with hemophilia A; a review article on the management of insomnia; a case report of a woman with postpartum fever, abdominal pain, and skin ulcers; and Perspectives on the ethics of relational AI, on anticipating the next pandemic, and on a first patient. Supplement to the New England Journal of Medicine, Vol. 391, No. 3.

2024-07-12 Hosts Craig Lipset and Jane Myles joined us for a discussion with Irina Grishina and Liz Quinlan (CSL Behring) about eConsent and challenges and successes with implementation.You can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.

Featuring articles on semaglutide and chronic kidney disease in type 2 diabetes, felzartamab in kidney-transplant rejection, bulevirtide and peginterferon for chronic hepatitis D, and nirsevimab and hospitalization for RSV bronchiolitis; a review article on malnutrition in adults; a case report of an infant with vomiting and hypercalcemia; and Perspectives on Medicare Advantage and consolidation’s new frontier, on orphan drugs and priorities for the future, on funding post-authorization vaccine-safety science, and on standing on her own two feet. Supplement to the New England Journal of Medicine, Vol. 391, No. 2.

Since its ‘birth’ in 1994, Frontline AIDS has worked local communities best placed to carry the shared mission to end AIDS for everyone, everywhere. In this episode, we explore how this unique approach to localization has delivered effective community-led results from Kenya to Ukraine - and ask what the future holds for the partnership.  Panelists: David Clark, Head: Programmes, Frontline AIDS Andriy Klepikov, Executive Director, Alliance for Public Health, Ukraine Dr. Lilian Otiso, LVCT Health  https://frontlineaids.org https://aph.org.ua/en/home https://lvcthealth.org #HIV #AIDS #communities #CBOs #impact #prevention #treatment #humanrights #stigma #ukraine #kenya

Featuring articles on stress ulcer prophylaxis during invasive mechanical ventilation, new therapies for hereditary angioedema, tissue factor–directed therapy in cervical cancer, and normalization of C1 inhibitor in a patient with hereditary angioedema; a review article on acute abdomen in the modern era; a Clinical Problem-Solving article on aggregating the loose threads; a Medicine and Society on a case for the Medical Civil Rights Act; and Perspectives on academic freedom in America; on water pollution, health, and medicine’s duty to engage; and on to forgive, divine. Supplement to the New England Journal of Medicine, Vol. 391, No. 1.

2024-06-28 Hosts Dr. Amir Kalali and Jane Myles were joined by Pete Fronte (Altura Health), Ruma Bhagat (Genentech) and Dr. Jim Schultz (Neighborhood Health) to discuss a white paper and toolkit released about Building Clinical Trial & Research Access via Community Health Centers. We look forward to hearing more about their work to engage underrepresented populations to diversify research enrollment.View the white paper/toolkit here --> https://alturastudies.com/research-ecosystems/#researchdiversitywhitepaperYou can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.

Featuring articles on treatments for eosinophilic esophagitis, reteplase versus alteplase for acute ischemic stroke, dupilumab for COPD with type 2 inflammation, and brigatinib in NF2-related schwannomatosis; a review article on amyloidosis; a case report of a man with recurrent fever and liver lesions; and Perspectives on Alzheimer’s disease, biomarkers, and mAbs; on climate litigation for protecting public health; on carbon-footprint analyses in RCTs; and on the phantom of the organ. Supplement to the New England Journal of Medicine, Vol. 390, No. 24.

2024-06-21 Hosts Craig Lipset, Dr. Amir Kalali, and Jane Myles were joined by Jonathan Cotliar (Science 37) for a discussion around their recent successful FDA Inspection of a decentralized meta-site, which is a huge milestone in virtual site quality assurance and compliance.You can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.

Featuring articles on combination therapy for diffuse large B-cell lymphoma, autosomal dominant Alzheimer’s disease, noninvasive ventilation for preoxygenation during emergency intubation, a novel anti-CD38 antibody in immune thrombocytopenia, and a glucose-responsive insulin for type 2 diabetes; a review article on congenital and acquired Chiari syndrome; a case report of a man with arthritis and rash; and Perspectives on ethics and innovative research on brain diseases, on sustaining and scaling up street medicine, and on the maternal crossroad. Supplement to the New England Journal of Medicine, Vol. 390, No. 23.

2024-06-14 Hosts Dr. Amir Kalali and Jane Myles were joined by Anthony Costello (Medidata) for a conversation around data diversity, data access, and rights, and his experience at Medidata, as well as industry wide.You can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.

2024-06-11 Hosts Craig Lipset, Dr. Amir Kalali, and Jane Myles were joined by Dr. Timil Patel, a Medical Oncologist with the FDA for a discussion around the recently released ASCO abstract around adoption of decentralized trial elements in cancer clinical trials during the pandemic.Clinical Trials Transformation Initiative (CTTI) and FDA (with support from Decentralized Trials & Research Alliance (DTRA) collected data from research sponsors to understand the methods that were adopted, the associated challenges to address, and the direction ahead. Read the ASCO abstract here --> https://meetings.asco.org/abstracts-presentations/237149You can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.

Featuring articles on T-cell cancer after CAR T-cell therapy, the early diagnosis and treatment of COPD and asthma, and the implications of race adjustment in lung-function equations; a review article on diets; a case report of a woman with the worst headache of her life; and Perspectives on efforts toward equity and on feeling guilty. Supplement to the New England Journal of Medicine, Vol. 390, No. 22.

2024-06-07 Host Craig Lipset was joined by a special guest host, Jean Sposaro (BMS) for our session around Sponsor Experience Implementing DCTs. TransCelerate Bio Pharma conducted a survey in 2023 to better understand the collective experience of TransCelerate members deploying decentralized clinical trial (DCT) elements beyond the COVID-19 pandemic. Ashley Butler (TransCelerate) and Joachim Lovin (Novo Nordisk) joined us for the discussion. TransCelerate's recently released whitepaper can be found here --> https://www.transceleratebiopharmainc.com/wp-content/uploads/2024/04/Sponsor-Experience-Implementing-Decentralized-Clinical-Trial-DCT-Elements-DCT-Implementation-Survey-Results_vFINAL-1.pdfYou can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.

2024-05-31 Hosts Amir Kalali and Jane Myles joined allowed guests to join as ask their burning questions about all things DCT. A discussion about the EX-US Market in Japan, adoption of DCT methods, and more were addressed during the live session.You can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.