Clinical Research and Drug Discovery Podcasts
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Latest Episodes
NEJM This Week — November 25, 2021
Featuring articles on spinal or general anesthesia for hip surgery, HIF-2α inhibition in von Hippel–Lindau disease, live birth after genetic testing for aneuploidy, belzutifan in the Pacak–Zhuang syndrome, and on responsible innovation in reproductive medicine; a review article on osteosarcoma; a case report of a man with pain and erythema of the left hand; and Perspective articles on why aducanumab is priced at $56,000 per patient, on Medicare coverage of aducanumab, and on the little things. Supplement to the New England Journal of Medicine, Vol. 385, No. 22.
November 24, 2021
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NEJM This Week — November 18, 2021
Featuring articles on hematopoietic gene therapy for Hurler syndrome, sotrovimab for early Covid-19, convalescent plasma for high-risk Covid-19, gene therapy for hemophilia A, parathyroid hormone resistance, and on hunger and mood; a review article on salt handling and blood pressure; a case report of a woman with pain in the left upper quadrant and hypoxemia; and Perspective articles on regulating drug prices while increasing innovation and on the drug-pricing debate redux. Supplement to the New England Journal of Medicine, Vol. 385, No. 21.
November 17, 2021
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NEJM This Week — November 11, 2021
Featuring articles on alteplase followed by endovascular treatment for stroke, sacubitril–valsartan in acute myocardial infarction, pembrolizumab in advanced cervical cancer, genome sequencing in health care, and screening for cervical cancer; a review article on pollution and the heart; a case report of a man with altered mental status and new onset of seizures; and Perspective articles on the future of SARS-CoV-2 vaccination and on when women and children made the policy agenda. Supplement to the New England Journal of Medicine, Vol. 385, No. 20.
November 10, 2021
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NEJM This Week — November 4, 2021
Featuring articles on new equations for estimating GFR without race, BNT162b2 vaccine at 6 months of follow-up, efficacy of the mRNA-1273 vaccine at the end of the blinded phase, providing grist for antitumor immunity; and continuity, fragmentation, and Adam Smith; a review article on peritoneal dialysis; a Clinical Problem-Solving describing a copycat; and Perspective articles on applying a subpopulation lens to population health, on racial and ethnic diversity at medical schools, and on none of the above. Supplement to the New England Journal of Medicine, Vol. 385, No. 19.
November 3, 2021
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NEJM This Week — October 28, 2021
Featuring articles on dual antiplatelet therapy in patients at high bleeding risk, itepekimab in moderate-to-severe asthma, risankizumab in severe asthma, and vaccine-induced thrombocytopenia and thrombosis; a review article on abdominal aortic aneurysms; a case report of a man with painful mouth ulcers; and Perspective articles on uncomfortable truths, on the 2021 reauthorization of the Child Abuse Prevention and Treatment Act, and on a therapeutic relationship. Supplement to the New England Journal of Medicine, Vol. 385, No. 18.
October 27, 2021
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NEJM This Week — October 21, 2021
Featuring articles on a randomized trial of a pan-PPAR agonist in NASH, outcomes in nonalcoholic fatty liver disease, the AQP1 promoter variant and peritoneal dialysis, obesity in childhood and GNAS mutations, and optogenetics recognized through the Lasker Award; a review article on point-of-care ultrasonography; a case report of a girl with swelling of the jaw and hypercalcemia; and Perspective articles on blood donation by gay and bisexual men, on the case for wage equity for essential health care workers, and on peak moments. Supplement to the New England Journal of Medicine, Vol. 385, No. 17.
October 20, 2021
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NEJM This Week — October 14, 2021
Featuring articles on empagliflozin in heart failure with preserved ejection fraction, oxytocin in autism spectrum disorder, breakthrough Covid-19 in health care workers, a cell-culture influenza vaccine, and data in crisis; a review article on aspergillus infections; a case report of a man with sore throat, epistaxis, and oropharyngeal petechiae; and Perspective articles on vigilante injustice, eviction and the necessary conditions for health, the drug-dosing conundrum in oncology, and on a good death. Supplement to the New England Journal of Medicine, Vol. 385, No. 16.
October 13, 2021
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NEJM This Week — October 7, 2021
Featuring articles on Covid-19 vaccine effectiveness in medical settings, immediate vs. delayed drainage for infected necrotizing pancreatitis, bamlanivimab plus etesevimab for Covid-19, third dose of Covid-19 vaccine in Israel, broadly neutralizing antibodies against all coronaviruses, striving for diversity in research studies, and mRNA vaccine research and the Lasker–DeBakey Award; a review article on autoimmune hemolytic anemias; a Clinical Problem-Solving on a woman with throat pain; and Perspective articles on methods of public health research, on the No Surprises Act and informed financial consent, and on integrating research into community practice. Supplement to the New England Journal of Medicine, Vol. 385, No. 15.
October 6, 2021
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NEJM This Week — September 30, 2021
Featuring articles on antidepressants in primary care practice, intensive blood-pressure control in older patients, ozanimod for ulcerative colitis, and Wnt proteins and structural birth defects; a review article on newer biologic and small-molecule therapies for IBD; a case report of a man with recurrent head and neck pain; and Perspective articles on moving toward a new era for the Indian Health System, on marking the 40th anniversary of the AIDS epidemic, and on cool water. Supplement to the New England Journal of Medicine, Vol. 385, No. 14.
September 29, 2021
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NEJM This Week — September 23, 2021
Featuring articles on artemisinin-resistant malaria in Africa, safety and efficacy of the NVX-CoV2373 vaccine, subcutaneous antibody combination and Covid-19, tebentafusp for uveal melanoma, reenergizing HCV vaccine development, and HER2-mutated breast cancer and overcoming drug resistance; a review article on mesothelioma; a case report of a boy with fever and developmental regression; and Perspective articles on public health law after Covid-19 and on revitalizing the U.S. primary care infrastructure. Supplement to the New England Journal of Medicine, Vol. 385, No. 13.
September 22, 2021
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NEJM This Week — September 16, 2021
Featuring articles on salt substitution and cardiovascular events, safety of the BNT162b2 mRNA Covid-19 vaccine, lutetium-177 in prostate cancer, typhoid vaccine in Malawian children, and a call for emergency action on the climate crisis; a review article on the treatment of acute appendicitis; a case report of a woman with Covid-19 and suicidal ideation; and Perspective articles on public option plans and on the treatment of older adults with cancer. Supplement to the New England Journal of Medicine, Vol. 385, No. 12.
September 15, 2021
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NEJM This Week — September 9, 2021
Featuring articles on a trial of mobile stroke units, iron interventions in infants in rural Bangladesh, somatic mutations in sporadic cerebral cavernous malformations, malaria vaccination with or without chemoprevention, and sensible but very cool advances in protein chemistry; a review article on the challenges of sarcoidosis and its management; a case report of an adolescent seeking HIV prophylaxis; and Perspective articles on SARS-CoV-2 human challenge studies, on supporting value-based health care, and on environmental racism and climate change. Supplement to the New England Journal of Medicine, Vol. 385, No. 11.
September 8, 2021
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NEJM This Week — September 2, 2021
Featuring articles on the inactivated SARS-CoV-2 vaccine in Chile, mycophenolate mofetil for immune thrombocytopenia, cardiovascular and renal outcomes with efpeglenatide, MRI-directed prostate biopsies, and natural killer cells in defense against HPV; a review article on chronic meningitis; a Clinical Problem-Solving describing inadequate support; and Perspective articles on population health and human rights, on Covid-induced changes in health care delivery, and on paying for digital health care. Supplement to the New England Journal of Medicine, Vol. 385, No. 10.
September 1, 2021
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NEJM This Week — August 26, 2021
Featuring articles on therapeutic anticoagulation in hospitalized patients with Covid-19, anticoagulation in moderate Covid-19, a monoclonal antibody for malaria prevention, triple therapy for cystic fibrosis, modeling heart development, and remembering past lessons about structural racism; a review article on heparin resistance; a case report of a man with relapsed acute myeloid leukemia; and Perspective articles on revisiting the FDA approval of aducanumab, on controversy and progress in Alzheimer’s disease, and on a pink salwar. Supplement to the New England Journal of Medicine, Vol. 385, No. 9.
August 25, 2021
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NEJM This Week — August 19, 2021
Featuring articles on adjuvant pembrolizumab in renal-cell carcinoma, oral atogepant for migraine prevention, male infertility and small noncoding RNAs, and adjunct immune globulin for vaccine-induced thrombotic thrombocytopenia; a review article on long-term survival after kidney transplantation; a case report of a man with fatigue and leg swelling; and Perspective articles on ending the campaign to undo the ACA in the courts, on Medicare Physician Payment Reform, and on the Covid-19 infodemic. Supplement to the New England Journal of Medicine, Vol. 385, No. 8.
August 18, 2021
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NEJM This Week — August 12, 2021
Featuring articles on vaccine effectiveness against the delta Covid-19 variant, injectable cabotegravir for prevention of HIV infection, antibody to factor XI after total knee replacement, year 1 of the Bundled Payments for Care Improvement–Advanced payment model, and on a new dimension in the RNA world; a review article on signature cytokines and immune-mediated inflammatory diseases; a case report of a woman with fever, sore throat, and confusion; and Perspective articles on confronting long-haul Covid, on the criminalization of gender-affirming care, and on when low tech wins. Supplement to the New England Journal of Medicine, Vol. 385, No. 7.
August 11, 2021
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NEJM This Week — August 5, 2021
Featuring articles on CRISPR-Cas9 disruption of TTR in transthyretin amyloidosis, tirzepatide versus semaglutide for type 2 diabetes, milrinone or dobutamine for cardiogenic shock, decompression versus fusion for lumbar spondylolisthesis, and SARS-CoV-2 and immunosuppression; a review article on age-related macular degeneration; a Clinical Problem-Solving on turning purple with pain; and Perspective articles on the complementarity of public health and medicine, on contact tracing for Covid-19, on supporting trainees from groups that are underrepresented in medicine, and on establishing medical civil rights. Supplement to the New England Journal of Medicine, Vol. 385, No. 6.
August 4, 2021
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NEJM This Week — July 29, 2021
Featuring articles on the duration of adjuvant therapy in breast cancer, tofacitinib for Covid-19 pneumonia, complications in youth-onset type 2 diabetes, a small-molecule SMN2 modifier in type 1 spinal muscular atrophy, a hyperimmune globulin to prevent congenital cytomegalovirus, and scarless wound healing; a review article on depression in adolescents; a case report of a woman with bloody stools and thrombocytopenia; and Perspective articles on from crime to care, on health care budgets for rural providers, on identifying and tracking SARS-CoV-2 variants, and on a child’s loss. Supplement to the New England Journal of Medicine, Vol. 385, No. 5.
July 28, 2021
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NEJM This Week — July 22, 2021
Featuring articles on PCI guided by FFR or angiography for STEMI, pimavanserin for dementia-associated psychosis, Covid-19 prevention and attenuation with mRNA vaccines, second-line treatment of HIV-1 infection in Sub-Saharan Africa, and racial inequality in prescription opioid receipt; a review article on substance use among men who have sex with men; a case report of a woman with cognitive impairment, headache, and memory loss; and Perspective articles on medical–financial partnerships, on Virchow at 200 and Lown at 100, and on one hundred years of insulin for some. Supplement to the New England Journal of Medicine, Vol. 385, No. 4.
July 21, 2021
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NEJM This Week — July 15, 2021
Featuring articles on rehabilitation after hospitalization for heart failure, detecting speech in a paralyzed person with anarthria, ruxolitinib for chronic graft-versus-host disease, BNT162b2 vaccination against Covid-19 in 12-to-15-year-old adolescents, and inhibiting PD-L1 in hepatocellular carcinoma; a review article on the initial management of seizure in adults; a case report of a pregnant woman with fever, abdominal pain, and headache; and Perspective articles on averting future vaccine inequity, on scaling up Covid-19 vaccination in Africa, and on a medical home. Supplement to the New England Journal of Medicine, Vol. 385, No. 3.
July 14, 2021
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NEJM This Week — July 8, 2021
Featuring articles on fetal surgery for severe left diaphragmatic hernia and for moderate left diaphragmatic hernia, comparisons of interleukin-17 inhibitors in psoriasis, and SARS-CoV-2 variants and vaccines; a review article on hematuria in adults; a case report of a man with ataxia; and Perspective articles on addressing vaccine hesitancy in BIPOC communities, on Covid-19 vaccine follow-through, and on the CT scan after 50 years. Supplement to the New England Journal of Medicine, Vol. 385, No. 2.
July 7, 2021
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NEJM This Week — July 1, 2021
Featuring articles on the treatment of multisystem inflammatory syndrome in children, a transglutaminase 2 inhibitor for celiac disease, daratumumab in light-chain amyloidosis, embryo selection in vitro, and clonal peregrinations in the placenta; a review article on cerebral venous thrombosis; a Clinical Problem-Solving on a brewing back pain; and Perspective articles on the learning health system, on whether learning is worth the trouble, and on Covid-19 and the investigator pipeline. Supplement to the New England Journal of Medicine, Vol. 385, No. 1.
June 30, 2021
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NEJM This Week — June 24, 2021
We discuss the latest in medical research and ideas.
June 23, 2021
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NEJM This Week — June 17, 2021
Featuring articles on mRNA Covid-19 vaccine safety in pregnant persons, hypothermia or normothermia after cardiac arrest, rituximab vs. mycophenolate mofetil for pemphigus, sudden cardiac death in persons with HIV, and SARS-CoV-2 vaccine design; a review article on infections in patients with cirrhosis; a case report of a man with cough, fever, and shortness of breath; and Perspective articles on promoting equity for women in medicine, on misogyny in medicine, and on escaping the labyrinth. Supplement to the New England Journal of Medicine, Vol. 384, No. 24.
June 16, 2021
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