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Clinical Research and Drug Discovery Podcasts

Clinical Research Podcasts

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NEJM This Week — May 13, 2021

We discuss the latest in medical research and ideas.
May 12, 2021
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NEJM This Week — May 6, 2021

Featuring articles on a trial of an antibody to amyloid in Alzheimer’s disease, short-course treatment of tuberculosis, weight loss maintenance with exercise and liraglutide, dexamethasone and surgical-site infection, a fountain of youthful retinal ganglion cells, and decoupling crisis response from policing; a review article on gastric emptying abnormalities in diabetes; a Clinical Problem-Solving on the inside and out; and Perspective articles on understanding and mitigating health inequities, on designing an independent public health agency, and on losing touch. Supplement to the New England Journal of Medicine, Vol. 384, No. 18.
May 5, 2021
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NEJM This Week — April 29, 2021

Featuring articles on vadadustat in non–dialysis-dependent chronic kidney disease, vadadustat for anemia in patients undergoing dialysis, oncolytic HSV therapy in pediatric glioma, blood-loss prevention after cesarean delivery, and diversity of the national medical student body; a review article on postpartum hemorrhage; a case report of a newborn girl with a neck mass; and Perspective articles on Australian firearm regulation at 25, on vaccination plus decarceration, and on the Zoom family meeting. Supplement to the New England Journal of Medicine, Vol. 384, No. 17.
April 28, 2021
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NEJM This Week — April 22, 2021

Featuring articles on interleukin-6 receptor blockade in severe Covid-19, tocilizumab in severe Covid-19 pneumonia, a microbiota-directed food supplement for malnutrition, sacituzumab govitecan in triple-negative breast cancer, and fighting SARS-CoV-2 with nanobodies; a review article on adrenal incidentaloma; a case report of a man with a rash on the scalp and face; and Perspective articles on advancing President Biden’s equity agenda, on encouraging acceptance of Covid-19 vaccines, and on Nanima. Supplement to the New England Journal of Medicine, Vol. 384, No. 16.
April 21, 2021
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NEJM This Week — April 15, 2021

Featuring articles on hypothermic machine perfusion in liver transplantation, a trial of psilocybin for depression, the effectiveness of the BNT162b2 mRNA vaccine in Israel, sedation in mechanically ventilated adults with sepsis, and soothing science skepticism; a review article on glomerular filtration and albuminuria; a case report of a woman with fever, flank pain, and inguinal lymphadenopathy; and Perspective articles on new legislation on out-of-network billing, on remote patient monitoring, and on remembering the Freedom House Ambulance Service. Supplement to the New England Journal of Medicine, Vol. 384, No. 15.
April 14, 2021
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NEJM This Week — April 8, 2021

Featuring articles on lenvatinib plus pembrolizumab in renal cell cancer, oxygenation targets for acute respiratory failure, cardiovascular risk and glycemic index, sutimlimab in cold agglutinin disease, extending life span in a mouse model of progeria, and overcoming Covid vaccine hesitancy; a review article on vestibular schwannomas; a case report of a man with depressed mood, unsteady gait, and urinary incontinence; and Perspective articles on combatting vaccine nationalism, on vancomycin infusion reaction, and on minds in crisis in a city in crisis. Supplement to the New England Journal of Medicine, Vol. 384, No. 14.
April 7, 2021
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NEJM This Week — April 1, 2021

Featuring articles on adjuvant nivolumab in esophageal cancer, sotatercept for pulmonary arterial hypertension, lumasiran for primary hyperoxaluria type 1, upadacitinib for psoriatic arthritis, and an Ebola relapse leading to transmission; a review article on glucose-lowering drugs to prevent cardiovascular disease; a Clinical Problem-Solving on stalking the diagnosis; and Perspective articles on emerging infectious diseases, on ensuring that LGBTQI+ people count, and on the first Black woman to earn a medical degree in the United States. Supplement to the New England Journal of Medicine, Vol. 384, No. 13.
March 31, 2021
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NEJM This Week — March 25, 2021

Featuring articles on the efficacy of the ALVAC–gp120 HIV vaccine, a JAK inhibitor or interleukin-4 blockade for atopic dermatitis, semaglutide for nonalcoholic steatohepatitis, enfortumab vedotin for relapse of urothelial cancer, the link between cancer and obesity, and embracing genetic diversity to improve Black health; a review article on atopic dermatitis; a case report of a boy with headache, abdominal pain, and hypertension; and Perspective articles on progress in vaccine technology, on addressing workforce diversity, and on the good fit. Supplement to the New England Journal of Medicine, Vol. 384, No. 12.
March 24, 2021
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NEJM This Week — March 18, 2021

Featuring articles on once-weekly semaglutide in adults with overweight or obesity, neutralizing antibodies to prevent HIV-1 infection, passive immunotherapy in patients with Covid-19, inhibition of C3 in paroxysmal nocturnal hemoglobinuria, and the political nature of sex; a review article on extrahepatic manifestations of chronic HCV infection; a case report of a woman with cholangiocarcinoma; and Perspective articles on private equity and physician medical practices, on the good doctor, and on the intern. Supplement to the New England Journal of Medicine, Vol. 384, No. 11.
March 17, 2021
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NEJM This Week — March 11, 2021

Featuring articles on a randomized trial of gestational diabetes screening, a neutralizing monoclonal antibody for hospitalized patients with Covid-19, risdiplam in type 1 spinal muscular atrophy, genome sequencing in myeloid cancers, a cautionary note about round spermatid injection, and supplying insulin while evading immunity; a review article on epistaxis; a case report of a man with shock, multiple organ failure, and rash; and Perspective articles on supporting clinical trainees with disabilities, on doctors with mental illness and structural barriers to disclosure, and on being breathless. Supplement to the New England Journal of Medicine, Vol. 384, No. 10.
March 10, 2021
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NEJM This Week — March 4, 2021

Featuring articles on baricitinib plus remdesivir for adults with Covid-19, albumin infusions in patients with cirrhosis, a trial of terlipressin for hepatorenal syndrome, nivolumab plus cabozantinib in renal-cell carcinoma, and on misrepresenting race; a review article on diffuse large B-cell lymphoma; a Clinical Problem-Solving describing a treacherous course; and Perspective articles on conquering atherosclerotic cardiovascular disease, on reform of payment for primary care, and on being without sanctuary. Supplement to the New England Journal of Medicine, Vol. 384, No. 9.
March 3, 2021
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NEJM This Week — February 25, 2021

Featuring articles on dexamethasone treatment in Covid-19, BCMA-specific CAR T cells in refractory myeloma, a cholinergic agonist and peripheral antagonist for schizophrenia, the Center for Medicare and Medicaid Innovation at 10 years, inflammation in ALS, and how structural racism works; a review article on β-thalassemias; a case report of a man with eye pain and decreased vision; and Perspective articles on last-mile logistics of Covid-19 vaccination, on telemedicine and medical licensure, and on the inequity of isolation. Supplement to the New England Journal of Medicine, Vol. 384, No. 8.
February 24, 2021
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NEJM This Week — February 18, 2021

Featuring articles on a C5a receptor inhibitor for ANCA vasculitis, convalescent plasma in Covid-19, relugolix combination therapy for uterine fibroid symptoms, and promoting Covid-19 vaccination in the United States; a review article on maintaining safety with SARS-CoV-2 vaccines; a case report of a man with delirium and renal insufficiency; and Perspective articles on vaccinating children against Covid-19 and on the FDA’s experience with Covid-19 antibody tests. Supplement to the New England Journal of Medicine, Vol. 384, No. 7.
February 17, 2021
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NEJM This Week — February 11, 2021

Featuring articles on repurposed antiviral drugs for Covid-19, a tirbanibulin ointment for actinic keratosis, a vestibular implant for bilateral vestibular hypofunction, antibodies and SARS-CoV-2 infection in health workers, a randomized trial of an HCV vaccine regimen, and regulatory T cells in multiple sclerosis; a review article on circadian mechanisms in medicine; a case report of a woman with dyspnea on exertion and abnormal findings on chest imaging; and Perspective articles on the future of drug-pricing transparency, on a shared evaluation platform for medical training, and on lessons from the Irish wake. Supplement to the New England Journal of Medicine, Vol. 384, No. 6.
February 10, 2021
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NEJM This Week — February 4, 2021

Featuring articles on an mRNA-1273 vaccine to prevent Covid-19, a trial of hydroxychloroquine to prevent Covid-19, breast cancer risk revisited, much ado about certain breast cancer genes, and race and genetic ancestry in medicine; a review article on antithrombotic therapy after acute coronary syndromes; a Clinical Problem-Solving describing the hunt for a diagnosis; and Perspective articles on vaccine innovations, on the search of a better equation, and on learning about end-of-life care from Grandpa. Supplement to the New England Journal of Medicine, Vol. 384, No. 5.
February 3, 2021
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NEJM This Week — January 28, 2021

Featuring articles on cryoablation for atrial fibrillation, inhaled treprostinil in interstitial lung disease, a levonorgestrel vs. copper IUD for emergency contraception, the return of cardiac activity after withdrawal of life support, and antigen presentation by B cells in multiple sclerosis; a review article on atrial fibrillation; a case report of a man with transient vision loss; and Perspective articles on reimagining infective endocarditis care amid the opioid epidemic, on a medical “ecology of attention”, and on the surgeon and the mother. Supplement to the New England Journal of Medicine, Vol. 384, No. 4.
January 27, 2021
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NEJM This Week — January 21, 2021

Featuring articles on inhibiting BCL11A to treat sickle cell disease and β-thalassemia, a polypill with or without aspirin in primary prevention, and neutralizing-antibody therapy in Covid-19; a review article on the effects of infection on natural immunity; a case report of a pregnant woman with ventricular tachycardia and shock; and Perspective articles on testing in a pandemic, on the Supreme Court and pandemic controls, and on incarceration and social death. Supplement to the New England Journal of Medicine, Vol. 384, No. 3.
January 20, 2021
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NEJM This Week — January 14, 2021

Featuring articles on omecamtiv mecarbil in systolic heart failure, sotagliflozin in diabetes with heart failure, sotagliflozin for heart failure in diabetes and kidney disease, bupropion and naltrexone for methamphetamine use, and procuring oligodendrocytes after spinal cord injury; a review article on Ewing’s sarcoma; a case report of a woman with lethargy and altered mental status; and Perspective articles on the Purdue Pharma opioid settlement, on drug-coated devices for peripheral arterial disease, and on the doctor as street-level bureaucrat. Supplement to the New England Journal of Medicine, Vol. 384, No. 2.
January 13, 2021
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NEJM This Week — January 7, 2021

Featuring articles on sitagliptin for prevention of acute GVHD, tocilizumab in Covid-19 pneumonia, rilonacept in recurrent pericarditis, vaginal mother-to-child transmission of cancer, and on whether the melanoma epidemic is real; a review article on osteoarthritis of the knee; a Clinical Problem-Solving on breathing for two; and Perspective articles on human molecular genetics and genomics, on Covid-19 and the undocumented Latinx community, and on the stress of Bayesian medicine. Supplement to the New England Journal of Medicine, Vol. 384, No. 1.
January 6, 2021
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NEJM This Week — December 31, 2020

Featuring articles on the safety and efficacy of an RNA-based SARS-CoV-2 vaccine, dexamethasone in chronic subdural hematoma, sleuthing out a severe adult inflammatory disorder, hemoglobin transfusion thresholds in infants, and vaccinating against SARS-CoV-2; a review article on the pathophysiology of inflammatory bowel diseases; a case report of a man with memory loss and odd behavior; and Perspective articles on reimagining how policymakers identify safety-net hospitals, on Medicaid and child health equity, on the FDA approval of remdesivir, and on whiteouts. Supplement to the New England Journal of Medicine, Vol. 383, No. 27.
December 30, 2020
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NEJM This Week — December 24, 2020

Featuring articles on ultrasound subthalamotomy for Parkinson’s disease, antenatal dexamethasone for early preterm birth, oral azacitidine maintenance therapy for AML, paclitaxel-coated devices in peripheral artery disease, and seizure frequency during pregnancy; a review article on estrogen receptor–positive breast cancer; a case report of a man with headache and Covid-19; and Perspective articles on the gift; on new order, new hope; on resilience in the face of Covid-19; and on holding up. Supplement to the New England Journal of Medicine, Vol. 383, No. 26.
December 23, 2020
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NEJM This Week — December 17, 2020

Featuring articles on SARS-CoV-2 transmission among Marine recruits, SARS-CoV-2 transmission on an aircraft carrier, an mRNA vaccine against Covid-19 in older adults, a phase 1 trial of an RNA-based Covid-19 vaccine, and the cardiomyocyte and the mighty mitochondrion; a review article on severe Covid-19; a case report of a boy with seizure and hypocalcemia; and Perspective articles on health coverage and care for transgender people, on rethinking sex designations on birth certificates, on being interviewed while Black, and on the caregiver. Supplement to the New England Journal of Medicine, Vol. 383, No. 25.
December 16, 2020
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NEJM This Week — December 10, 2020

Featuring articles on lipid lowering through activation of lipoprotein lipase, on a SARS-CoV-2 recombinant nanoparticle vaccine, on tocilizumab in Covid-19, and on survival with olaparib in prostate cancer; a review article on spontaneous coronary-artery dissection; a case report of a man with cancer and acute hypoxemia; and Perspective articles on the discovery of hepatitis C, on how Medicare Part D has failed to deliver savings to older adults, on a pandemic within a pandemic, and on Telephone. Supplement to the New England Journal of Medicine, Vol. 383, No. 24.
December 9, 2020
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NEJM This Week — December 3, 2020

Featuring articles on pembrolizumab in microsatellite-unstable colorectal cancer, the effect of finerenone on chronic kidney disease outcomes, person-to-person spread of Andes virus, malaria chemoprophylaxis in sub-saharan Africa, and epigenetic regulation in prostate cancer; a review article on cytokine storm; a Clinical Problem-Solving on looking for the outsider; and Perspective articles on solving population-wide obesity, on the bottom of the health care rationing iceberg, on understanding questions and answers about Covid-19 vaccination, and on why we need black physicians in academic medicine. Supplement to the New England Journal of Medicine, Vol. 383, No. 23.
December 2, 2020
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