Clinical Research and Drug Discovery Podcasts

Clinical Research Podcasts

Latest Episodes

NEJM This Week — September 29, 2022

Featuring articles on a bionic pancreas in type 1 diabetes, bronchodilators in symptomatic tobacco-exposed persons, acetazolamide in acute decompensated heart failure, and a new target for CAR T cells in myeloma; a review article on gastroesophageal reflux disease; a case report of a newborn girl with hypoglycemia; and Perspective articles on the war-zone mentality, on intradermal vaccination for monkeypox, on product hopping in the drug industry, and on a hidden crisis. Supplement to the New England Journal of Medicine, Vol. 387, No. 13.
September 28, 2022
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NEJM This Week — September 22, 2022

Featuring articles on glycemic outcomes of glycemia reduction, microvascular outcomes of glycemia reduction, dapagliflozin in heart failure with preserved ejection fraction, and an antisense oligonucleotide for SOD1 ALS; a review article on Burkitt’s lymphoma; a case report of a man with chronic diarrhea and autoimmune enteropathy; and Perspective articles on the law of licensure and quality regulation, on pushing back with pills, and on the seeds of ignorance. Supplement to the New England Journal of Medicine, Vol. 387, No. 12.
September 21, 2022
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The Evaluation and Management of Concussions

Dr. Brian Cole is joined by Dr. Elizabeth Pieroth, the Director of the Concussion Program at Midwest Orthopaedics at Rush, to talk about the evaluation and management of concussions. Dr. Pieroth is a Board Certified Clinical Neuropsychologist and is the Head Injury/Concussion specialist for the Chicago Bears, Blackhawks, White Sox, Fire, and the National Women’s Soccer League, as well as numerous colleges and high schools across the State of Illinois. Dr. Pieroth is the Co-Director of the NFL Neuropsychology Consulting Program. She is also on the Board of Directors of the Brain Injury Association of Illinois and is a member of the USA Football Heads Up Advisory Committee, the NFL Head, Neck and Spine Committee, the US Soccer Concussion Task Force and the Amateur Hockey Association of Illinois Safety Committee.
September 20, 2022
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Sharing the Mic Ep04 – Financing the Global Fund to Fight AIDS, TB and Malaria

World leaders meet in New York this week, to commit - hopefully - $18 billion over the next three years to the Global Fund in its fight to end AIDS, TB and Malaria - as well as COVID-19, and in this episode, we are again sharing the mic with Frontline AIDS to explore how communities themselves lead country programs funded by the Global Fund, as well as the critical advocacy role they are playing right now to keep the world’s attention focused on the three diseases. Joining Ben are: Kanna Dharmarajah Lead HIV and Financing, Frontline AIDS Eddie Mkhatjwa, Project Manager, CANGO, Eswatini Yvette Raphael, Executive Director, Advocates for the Prevention of HIV in Africa, South Africa #FightForWhatCounts #HIV #AIDS #TB #Malaria #COVID-19 #UNGA #UNGA77 #pandemics
September 20, 2022
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NEJM This Week — September 15, 2022

Featuring articles on a polypill for secondary cardiovascular prevention, anticoagulation in atrial fibrillation with rheumatic heart disease, aggressive or moderate hydration in acute pancreatitis, and enteral glutamine for burn injuries; a review article on Covid-19 vaccines; a case report of a man with headache and progressive neurologic dysfunction; and Perspective articles on protecting pregnant people from climate change, on professional civil disobedience, on closing the public health ethics gap, and on finding a new mantra. Supplement to the New England Journal of Medicine, Vol. 387, No. 11.
September 14, 2022
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Doomsday Watch Meets Global Health (with Guest Arthur Snell)

Ben meets Arthur Snell, former UK diplomat, host of the Doomsday Watch Podcast, and author of the Amazon UK bestseller “How Britain Broke The World” to explore how the greatest challenges facing the international community are radically changing global health priorities. Arthur reflects on the wide-ranging impacts of Russia’s ill-fated invasion of Ukraine, NATO’s retreat from Afghanistan, and what to expect from the new British Prime Minister Liz Truss - particularly whether the UK will follow the lead of the US and European partners and support the 7th replenishment of the Global Fund. #globalsecurity #Ukraine #globalhealthsecurity #pandemics #pandemicspreparation #pandemicsresponse #HIV #AIDS #malaria #tb #covid #LizTruss #GlobalFund
September 8, 2022
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NEJM This Week — September 8, 2022

Featuring articles on an open-source automated insulin delivery system in type 1 diabetes, closed-loop therapy in type 1 diabetes, litifilimab for systemic lupus erythematosus, routine functional testing after PCI, metagenomic sequencing and infectious disease, and race correction and the x-ray machine; a review article on personality disorders; a case report of a man with confusion, headache, and fever; and Perspective articles on emergency department ethics in a post-Roe era, on EMTALA for pregnancy-related emergencies, and on science, competing values, and trade-offs. Supplement to the New England Journal of Medicine, Vol. 387, No. 10.
September 7, 2022
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NEJM This Week — September 1, 2022

Featuring articles on FFR versus intravascular ultrasonography to guide PCI, nirmatrelvir for Covid-19 during the omicron surge, antiretroviral HIV treatment in pregnancy, regimens for drug-resistant tuberculosis, and on building Black wealth; a review article on chronic urticaria; a Clinical Problem-Solving on telescoping the diagnostic process; and Perspective articles on what Dobbs means for patients with breast cancer, on the escalating cybersecurity threat to health care, on “fertility fraud” legislation, on updated health warnings for alcohol, and on losing contact. Supplement to the New England Journal of Medicine, Vol. 387, No. 9.
August 31, 2022
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What Is A High Ankle Sprain?

Dr. Brian Cole is joined by Joshua James, DPT, CSCS from RUSH Physical Therapy to discuss high ankle sprains, including how they are diagnosed and the best treatments to help athletes recover.
August 29, 2022
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NEJM This Week — August 25, 2022

Featuring articles on the clinical features of monkeypox in humans, the treatment of diabetic macular edema, ublituximab in relapsing multiple sclerosis, olokizumab for rheumatoid arthritis, and on when silence disrupts; a review article on lesions of the ovary and fallopian tube; a case report of a woman with cystic lung disease; and Perspective articles on the physician–patient relationship, on hospital care for substance use disorder, and on improving the use of FDA advisory committees. Supplement to the New England Journal of Medicine, Vol. 387, No. 8.
August 24, 2022
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Caffeine and Caffeine Supplements: Spilling the Beans on Caffeine

Caffeine is the most popular psychoactive substance in the world, with 89 percent of people in the U.S. consuming at least one drink containing caffeine daily. People depend on caffeine or caffeine supplements for a temporary energy boost, to stay alert, to enhance focus, and even to improve their mood. With so many people so dependent on caffeine, today we are going to take an in-depth look at caffeine pills and supplements.
August 18, 2022
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NEJM This Week — August 18, 2022

Featuring articles on glycemic criteria for the diagnosis of gestational diabetes, a randomized trial of metformin, ivermectin, and fluvoxamine for Covid-19, and children with acute hepatitis of unknown cause; a review article on neuromyelitis optica spectrum disorder; a case report of a woman with headache and blurred vision; and Perspective articles on confronting health worker burnout, on tecovirimat and the treatment of monkeypox, on framing traumatic injury as a chronic condition, and on professionals as targets in the culture wars. Supplement to the New England Journal of Medicine, Vol. 387, No. 7.
August 17, 2022
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NEJM This Week — August 11, 2022

Featuring articles on redirecting T cells against myeloma cells, the removal of small kidney stones and relapse, the treatment of severe alpha1-antitrypsin deficiency, and BNT162b2 protection against omicron in children; a review article on bronchiectasis; a case report of a man with perianal and penile ulcers, pain, and rash; and Perspective articles on race and ethnicity in Covid risk assessments, on understanding Covid vaccine efficacy over time, on noncompete agreements, on bringing sickle-cell treatments to sub-Saharan Africa, and on a critical shortage of iodinated contrast material. Supplement to the New England Journal of Medicine, Vol. 387, No. 6.
August 10, 2022
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NEJM This Week — August 4, 2022

Featuring articles on a monoclonal antibody to prevent malaria infection, monoclonal antibody therapy in Parkinson’s disease, and dulaglutide in youths with type 2 diabetes; a review article on spina bifida; a Clinical Problem-Solving on diagnostic aspirations; and Perspective articles on building a national public health system in the U.S., on a preview of the dangerous future of abortion bans, on the end of Roe v. Wade, and on code words. Supplement to the New England Journal of Medicine, Vol. 387, No. 5.
August 3, 2022
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Global Health Security – Part 2

Just prior to AIDS 2022, Ben sat down with Steve Morrison, one of the world’s leading thinkers on how health fits into new trends in global security. He shares his views on the impact of the Russian Invasion of Ukraine, COVID-19 and other current and future infectious outreaks on nations’ security.  Guest: J. Stephen Morrison, Senior Pice President at the Center for Strategic and International Studies (CSIS) and Director of its Global Health Policy Center. #CSIS #globalsecurity #globalhealthsecurity #pandemics #pandemicspreparation #pandemicsresponse #HIV #AIDS #malaria #tb #covid
August 2, 2022
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HIV and COVID-19: A Private Sector Example of Transferable and New Solutions

COVID-19 has upended society, from vaccine inequity, to healthcare and to the way we work. In this #aids2022 podcast, we look at how one San Francisco Bay Area-based multinational - Chevron - has responded to COVID-19, by building on its heritage of partnerships forged over 30 years of the AIDS response. Joining Ben, are friends of the podcast: Dr. Huma Abbasi, Chief Medical Officer, Chevron Dr. Chinwe Okala, Lead Physician Chevron Nigeria Ambassador Eric Goosby, UCSF and UN Special Envoy on TB Lance Toma, CEO of the SF Community Health Center Chris Collins, CEO of Friends of the Global Fight Sally Ethelston, Director, Resource Mobilization and Outreach, Malaria Vaccines #COVID19 #HIV #AIDS #TB #malaria #business #partnerships #community #ESG #corporateresponsibility
July 31, 2022
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Sharing the Mic Ep03 – AIDS 2022: New Report on Human Rights Violations

In this episode we provide our listeners and viewers with an overview of the key Frontline AIDS activities at the upcoming AIDS 2022 conference in Montreal – particularly the launch of the Report “Protectors or Perpetrators?” – highlighting how unlawful policing practices are affecting the communities most affected by AIDS – and showcasing the leadership of those same communities in documenting and responding to human rights violations.    The panelists for this episode are − Host, Ben Plumley − Oratile Moseki, Lead Human Rights Advocacy (Human Rights), Frontline AIDS − Micheal Ighodaro, Prevention Access Campaign & Trustee of Frontline AIDS  − Liberty Matthyse, Executive Director, Gender Dynamix South Africa − Victoria Kalyniuk, REAct Regional Coordinator, Alliance for Public Health Ukraine Directed by Erik Espera, NewsDoc Media Produced by Troy Espera Frontline AIDS producer Allie Liu
July 28, 2022
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Managing Pandemics: Pathways to Better Diagnostics in Infectious Disease

It’s obvious, really, that you can’t treat your way out of a pandemic without the right diagnostics to tell you who is infected, and with which variant of virus or bacterium - and in this episode Ben chats with two leading experts on how laboratory and point of care diagnostics form the essential backbone to any effective infectious disease public health program. Sponsored by Roche Molecular. Ben is joined by Dr. Tamar Tchelidze, and Dr. Ben La Brot, physicians from Roche Molecular Systems Inc, both with deep frontline expertise in combating pandemics. #infectiousdisease #pandemics #covid #HIV #AIDS #tb #malaria #pandemicsresponse #diagnostics #laboratory #treatment #testing #prevention #screening #PrEP #injectables
July 28, 2022
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NEJM This Week — July 28, 2022

Featuring articles on supplemental vitamin D and incident fractures, brentuximab vedotin in advanced Hodgkin’s lymphoma, litifilimab for cutaneous lupus erythematosus, genetic protection against liver disease, and on lawmakers v. the scientific realities of human reproduction; a review article on tobacco addiction; a case report of a man with hypoglycemia; and Perspective articles on the history of health law in the United States, on primary care and financial risk, and on achieving the Triple Aim for sexual and gender minorities. Supplement to the New England Journal of Medicine, Vol. 387, No. 4.
July 27, 2022
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NEJM This Week — July 21, 2022

Featuring articles on tirzepatide for weight loss in adults with obesity, pembrolizumab in triple-negative breast cancer, Covid-19 vaccination in children 5 to 11 years of age, and gene therapy for hemophilia B; a review article on obesity in pregnancy; a case report of a woman with cavitary lung lesions; and Perspective articles on communicating statistics on climate change, on Medical Device User Fee reauthorization, and on grieving in a pandemic. Supplement to the New England Journal of Medicine, Vol. 387, No. 3.
July 20, 2022
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NEJM This Week — July 14, 2022

We discuss the latest in medical research and ideas.
July 13, 2022
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The Impact of Playing School Sports with Guest Mickey Pruitt

Former NFL linebacker and current Director of Sports for Chicago Public Schools (CPS) joins Dr. Brian Cole to discuss the importance that school sports have on young students. Pruitt oversees 23 sports, with tens of thousands of CPS athletes; guiding the very program that enriched his life as a teenager in Chicago. Pruitt was an all-state halfback and safety at Robeson High School in Englewood, Ill.
July 11, 2022
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NEJM This Week — July 7, 2022

Featuring articles on trastuzumab deruxtecan in HER2-low breast cancer, effects of previous infection and vaccination on symptomatic omicron infections, and a report on porcine-to-human cardiac transplantation; review articles on pulmonary embolism and on the vaccine-hesitant moment; a Clinical Problem-Solving on the young and the breathless; and Perspective articles on physicians spreading misinformation on social media, on dietary supplements and institutionalizing misinformation, and on the portal. Supplement to the New England Journal of Medicine, Vol. 387, No. 1.
July 6, 2022
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NEJM This Week — June 30, 2022

Featuring articles on restricted intravenous fluid in septic shock, an oncolytic virus for pediatric pontine glioma, ibrutinib for untreated mantle-cell lymphoma, and on the potency of a KRAS silent variant; a review article on mantle-cell lymphoma; a case report of a man with vision changes; and Perspective articles on nineteen days in America, on a comprehensive Covid-19 response, on the solution shop and the production line, and on being without question. Supplement to the New England Journal of Medicine, Vol. 386, No. 26.
June 29, 2022
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