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Clinical Research and Drug Discovery Podcasts

Clinical Research Podcasts

Latest Episodes

NEJM This Week — December 19, 2024

Featuring articles on cancer cachexia, MDR tuberculosis, Ebola virus disease, and severe asthma; a review article on the nonsurgical management of chronic venous insufficiency; a case report of a woman with end-stage liver disease and headache; and Perspectives on providing effective medical care to autistic people, on independent physician associations, on face-to-face learning, and on those who are well known to us. Supplement to the New England Journal of Medicine, Vol. 391, No. 24.
December 18, 2024
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The Best of Aging Fast & Slow: A Recap of Powerful Conversations

Join hosts Drs. Sarah Szanton and Deidra Crews for a special segment as they recap highlights from past episodes on structural resilience. From enlightening dialogues on health equity to inspiring advice from researchers, they revisit key moments and share their reflections on the insights gained. Whether you’re a longtime listener or new to the show, this episode offers peak moments to savor from many perspectives. 
December 18, 2024
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NEJM This Week — December 12, 2024

Featuring articles on PCI before transcatheter aortic-valve implantation, treatments in patients with type 2 diabetes, in leprosy, in refractory adult ALL, and in ATTR cardiomyopathy; a review article on drug reaction with eosinophilia and systemic symptoms; a case report of a boy with recurrent fever; and Perspectives on an autopsy of a drug withdrawal, on clearing dense drug-patent thickets, on how a survey change sheds light on iatrogenic opioid use disorder and on being tethered. Supplement to the New England Journal of Medicine, Vol. 391, No. 23.
December 11, 2024
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The Future of the Global HIV Response: A Post-World AIDS Day Reflection

A Shot in the Arm Podcast is proud to bring you another installment of Global Health Diplomats! In this compelling episode, co-hosts Ben Plumley and Eric Goosby dive deep into the future trajectory of the global HIV response. Following World AIDS Day, the discussion spans a 38,000-foot view of where the HIV epidemic stands, its critical challenges, and the evolving strategies needed for a sustainable, long-term response. From the impact of geopolitical shifts on access to treatment and care to the integration of HIV programs with broader primary healthcare systems, this episode unpacks the most pressing issues in global health today. Key Highlights: HIV Goals for 2030: Reality Check Are we close to ending AIDS as a public health crisis? Dr. Eric Goosby reflects on the progress made and the significant hurdles ahead. Quote: "We've built breathtaking infrastructure over 25 years, but it’s clear we won’t cross the 2030 finish line without major shifts." (Eric Goosby, 00:01:24) The Role of Targets in the HIV Response Are political targets still relevant in today’s complex world? Ben and Eric debate the pros and cons of target-driven approaches in global health. Quote: "Targets have driven investment and expanded care, but we may need to rethink them in light of new challenges." (Eric Goosby, 00:05:26) Primary Care Integration Why the HIV response must pivot toward integrated primary healthcare to address non-communicable diseases and pandemic preparedness. Quote: "For people living with HIV, coronary artery disease, hypertension, and cancer are now the bigger threats. Primary care is key." (Eric Goosby, 00:07:46) The Geopolitical Impact on HIV Care Rising anti-rights movements and geopolitical challenges make it harder to bring marginalized populations into care. Quote: "The rights-based approach to care is under siege globally, making access for key populations even tougher." (Ben Plumley, 00:10:04) Funding Sustainability Beyond 2030 Exploring innovative funding mechanisms, domestic ownership, and the evolving role of multilateral agencies like the Global Fund. Quote: "Transitioning to country-driven funding is essential. It’s time for governments to take ownership." (Eric Goosby, 00:30:01) HIV Prevention’s Urgent Need for Innovation Despite treatment advancements, global prevention efforts lag behind, especially for at-risk populations. Quote: "Prevention needs to focus on behavior, access, and new technologies like PrEP for real impact." (Eric Goosby, 00:37:26) Upcoming Episodes in the Series: Rights-Based Approaches in HIV Care Funding the Future: Domestic Resource Mobilization for HIV Programs Prevention Innovation: From Behavioral Change to Biomedical Solutions Reimagining Global Health Architecture Post-2030 Acknowledgments: This podcast is made possible by the generous support of the John T. Martin Foundation. Produced by Erik Espera of NewsDoc Media. Subscribe and Share: Stay tuned for more in-depth discussions on the future of global health. Subscribe to Global Health Diplomats wherever you download podcasts, and leave us a five-star review to support the conversation! Share your thoughts and join the discussion on social media using #GlobalHealthDiplomats and #WorldAIDSDay2024!
December 9, 2024
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Investigating Data Quality in Hybrid Clinical Studies

2024-12-06 Hosts Craig Lipset, Amir Kalali, and Jane Myles were joined by Anna Yang and Elizabeth Mandel (Genentech) joined us for a discussion around defining, measuring, and benchmarking data quality with 2 ongoing hybrid studies.You can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.
December 9, 2024
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NEJM This Week — December 5, 2024

Featuring articles on treatments for atrial fibrillation and stable coronary disease, for chronic hepatitis B, and for metastatic breast cancer; the 30-year cardiovascular disease risk in healthy women; and prenatal screening and detection of maternal cancer; a review article on sepsis and septic shock; a case report of a woman with headache, fever, and respiratory failure; and Perspectives on Medicare’s bundled-payment programs, on handcuffs and unexpected deaths, on the Marburg outbreak in Rwanda, and on the care that saved one parent. Supplement to the New England Journal of Medicine, Vol. 391, No. 22.
December 4, 2024
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World AIDS Day 2024: Human Rights In Action Against HIV

Episode Title: World AIDS Day 2024: Human Rights In Action Against HIV Guests: Hon. Mmapaseka Steve Letsike, Deputy Minister Women, Youth, and Persons with Disabilities, South Africa Dr. Mandeep Dhaliwal, Director of the HIV and Health Group, United Nations Development Programme (UNDP) Description: In this powerful episode of A Shot in the Arm Podcast, host Ben Plumley dives deep into the intersection of human rights and global health with two inspiring leaders: Honorable Deputy Minister Steve Letsike from South Africa and Dr. Mandeep Dhaliwal, head of HIV at the UN Development Programme (UNDP) — Together, they explore the evolving HIV response, challenges in addressing stigma and discrimination, and the critical role of governance and community leadership in achieving the global goal of ending AIDS as a public health crisis by 2030. What You'll Learn in This Episode: The Hon. Steve Letsike’s transition from LGBTQ+ and HIV activist to a key governmental leader. Dr. Mandeep Dhaliwal’s insights on the UNDP's role in driving global change in HIV policies and human rights advocacy. How human rights are intrinsically linked to HIV prevention and care. The global and local implications of criminalization and stigma on HIV responses, with examples from countries like South Africa and Uganda. The significance of integrating diverse issues like gender-based violence, poverty, and structural inequalities into the fight against HIV. Key Moments: [00:01:08] Hon. Steve Letsike reflects on moving from activism to governance. [00:10:52] Dr. Mandeep Dhaliwal discusses how governance and policies shape HIV responses globally. [00:22:22] Connecting human rights to effective HIV prevention and care strategies. [00:27:15] The balance between donor aid reliance and self-sustained national HIV programs. [00:30:22] The path toward achieving the goal of ending AIDS by 2030 and the obstacles that remain. Notable Quotes: "Governments belong to the people. We all have to contribute differently to achieve a just and equal society." - Hon. Steve Letsike "Without human rights, we won't realize the potential of ending AIDS as a public health threat by 2030." - Dr. Mandeep Dhaliwal   Subscribe for more episodes focusing on global health equity and innovation!   Follow us on Spotify, YouTube, and wherever you get your podcasts. #WorldAIDSDay2024 #EndAIDS2030 #HumanRights #GlobalHealth #UNAIDS #HIVAwareness #UNDP
December 1, 2024
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World AIDS Day 2024: Human Rights In Action Against HIV

Episode Title: World AIDS Day 2024: Human Rights In Action Against HIV Guests: Hon. Mmapaseka Steve Letsike, Deputy Minister Women, Youth, and Persons with Disabilities, South Africa Dr. Mandeep Dhaliwal, Director of the HIV and Health Group, United Nations Development Programme (UNDP) Description: In this powerful episode of A Shot in the Arm Podcast, host Ben Plumley dives deep into the intersection of human rights and global health with two inspiring leaders: Honorable Deputy Minister Steve Letsike from South Africa and Dr. Mandeep Dhaliwal, head of HIV at the UN Development Programme (UNDP) — Together, they explore the evolving HIV response, challenges in addressing stigma and discrimination, and the critical role of governance and community leadership in achieving the global goal of ending AIDS as a public health crisis by 2030. What You'll Learn in This Episode: The Hon. Steve Letsike’s transition from LGBTQ+ and HIV activist to a key governmental leader. Dr. Mandeep Dhaliwal’s insights on the UNDP's role in driving global change in HIV policies and human rights advocacy. How human rights are intrinsically linked to HIV prevention and care. The global and local implications of criminalization and stigma on HIV responses, with examples from countries like South Africa and Uganda. The significance of integrating diverse issues like gender-based violence, poverty, and structural inequalities into the fight against HIV. Key Moments: [00:01:08] Hon. Steve Letsike reflects on moving from activism to governance. [00:10:52] Dr. Mandeep Dhaliwal discusses how governance and policies shape HIV responses globally. [00:22:22] Connecting human rights to effective HIV prevention and care strategies. [00:27:15] The balance between donor aid reliance and self-sustained national HIV programs. [00:30:22] The path toward achieving the goal of ending AIDS by 2030 and the obstacles that remain. Notable Quotes: "Governments belong to the people. We all have to contribute differently to achieve a just and equal society." - Hon. Steve Letsike "Without human rights, we won't realize the potential of ending AIDS as a public health threat by 2030." - Dr. Mandeep Dhaliwal   Subscribe for more episodes focusing on global health equity and innovation!   Follow us on Spotify, YouTube, and wherever you get your podcasts. #WorldAIDSDay2024 #EndAIDS2030 #HumanRights #GlobalHealth #UNAIDS #HIVAwareness #UNDP
December 1, 2024
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2024 UNAIDS World AIDS Day Report: The Rights Way to End the Epidemic?

Episode Title: 2024 UNAIDS World AIDS Day Report: The Rights Way to End the Epidemic? Host: Ben Plumley, Global Health Strategist Guest: Christine Stegling, Deputy Executive Director, UNAIDS Episode Summary: Welcome to A Shot in the Arm Podcast! In this first of a set of special World AIDS Day 2024 episodes, host Ben Plumley chats with Christine Stegling, Deputy Executive Director of UNAIDS. They delve into the key themes of this World AIDS Day’s UNAIDS report, "Taking the Rights Path to End AIDS", which profiles the critical role of human rights in tackling the HIV/AIDS epidemic. Christine highlights the intersection of biomedical interventions and human rights, explaining why creating an enabling environment is essential for ending the AIDS epidemic. A skeptical Ben asks if this is possible by the international target of 2030. Other topics include the challenges posed by stigma, discrimination, and policy barriers, and how countries can ensure equitable access to prevention and treatment services. Key Takeaways: The 2030 Goal: is it possible? What does it mean to end AIDS as a public health threat? Human Rights Approach: Why protecting human rights is as crucial as advancing biomedical interventions. Global Challenges: Updates on rights rollbacks, policy barriers, and their impact on HIV prevention in countries like Uganda and the Philippines. Country Leadership: How UNAIDS supports nations in creating sustainable, inclusive HIV responses. Bright Spots: Positive changes in Botswana under new leadership with a strong human rights focus. Additional Insights: The episode also touches on global advocacy strategies for HIV prevention amidst political and social challenges, including UNAIDS' role in navigating shifting donor priorities and supporting countries to take ownership of their epidemic responses. Resources Mentioned: UNAIDS 2024 Report: Taking the Rights Path to End AIDS Learn more about UNAIDS’ global initiatives: UNAIDS Website Producer: Erik Espera, NewDoc Media   Subscribe for more episodes focusing on global health equity and innovation!   Follow us on Spotify, YouTube, and wherever you get your podcasts. #WorldAIDSDay2024 #EndAIDS2030 #HumanRights #GlobalHealth #UNAIDS #HIVAwareness
November 29, 2024
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NEJM This Week — November 28, 2024

Featuring articles on pembrolizumab perioperative therapy in breast cancer, reduced dose schedules or fractional doses of pneumococcal conjugate vaccine, and nivolumab plus ipilimumab in colorectal cancer; a review article on degenerative rotator-cuff disorders; a case report of a man with seizures and agitation; a Clinical Implications of Basic Research on boning up on boning up; and Perspectives on the Duffy null phenotype; on sickle cell trait, inequity, and the need for change, on “target trial emulation” for observational studies, and on a good day. Supplement to the New England Journal of Medicine, Vol. 391, No. 21.
November 27, 2024
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Increasing Adoption of Wearables in Clinical Trials

2024-11-22 Hosts Craig Lipset, Amir Kalali, and Jane Myles were joined by Keith Robinson, MD, MS, FCCP and Megan Parisi, MS, CCRP from Syneos Health and Nick Delmonico from Strados Labs for a discussion around wearables. We discussed challenges in increasing adoption of wearables, factors that are holding things back from greater widespread adoption, and the benefits/ROI of wearables and novel measurements.You can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.
November 25, 2024
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NEJM This Week — November 21, 2024

Featuring articles on a nationwide couple-based genetic screening; adjunctive embolization for subdural hematoma; a late-liver-stage attenuated malaria vaccine; and climate change, floods, and human health; a review article on Candida auris infections; a case report of a girl with abdominal pain; and Perspectives on Medicare’s first round of drug-price negotiation; on invisible deaths; on minding the sentinel; and on Saint Didacus, fetal death, and dual loyalty. Supplement to the New England Journal of Medicine, Vol. 391, No. 20.
November 20, 2024
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Ebola, Bombs, and Migrants: A Conversation with Dr. Joanne Liu

Title: Ebola, Bombs, and Migrants: A conversation with Dr. Joanne Liu Host: Ben Plumley Guest: Dr. Joanne Liu, Pediatric Emergency Physician and Former International President of Médecins Sans Frontières (Doctors Without Borders) Episode Summary: In this episode, Ben Plumley interviews Dr. Joanne Liu, a pediatric emergency physician from Montreal, Quebec, and former international president of Médecins Sans Frontières (Doctors Without Borders). Dr. Liu discusses her new book, "L’Ebola, les bombes et les migrants," which delves into the interconnected crises of pandemics, conflict, and migration. The conversation covers her experiences and insights from her tenure at MSF, the impact of global crises on public health, and the importance of recognizing our common humanity. Key Topics: Introduction to Dr. Joanne Liu: Her background as a pediatric emergency physician and former president of MSF. New Book Discussion: "L’Ebola, les bombes et les migrants" and its exploration of the polycrises of pandemics, conflict, and migration. Pandemic Preparedness: Reflections on the COVID-19 pandemic, the importance of public health awareness, and the need for better preparedness for future pandemics. Climate Crisis: The impact of climate change on health and the emergence of new diseases. Migration: Dr. Liu's personal connection to migration, the challenges faced by migrants, and the need for a rights-based approach. Conflict and Health: The targeting of health facilities in conflicts, the importance of international humanitarian law, and the role of international institutions in addressing these issues. Call to Action: Dr. Liu emphasizes the need for individual and collective action to address global challenges and uphold our common humanity. Notable Quotes: "We need to recognize the humanity in the other person, the person we call other, because if we don't, we are denying our own humanity." "Wishful thinking is not a strategy, and it's not an operational plan." Production Team: Director and Producer: Erik Espera of NewsDoc Media Assistant Producer: Y-Isha Raphael Links: Link to Dr. Liu's book https://editionslibreexpression.groupelivre.com/products/lebola-les-bombes-et-les-migrants Connect with Us If you enjoyed this episode, please subscribe, rate us five stars, and share the conversation on global health equity. For more updates, follow us on LinkedIn, YouTube, and Spotify. Facebook and Instagram: @ShotArmPodcast Youtube: www.youtube.com/@shotarmpodcast LinkedIn: https://www.linkedin.com/company/shotarmpodcast Spotify: https://open.spotify.com/show/69XpqCLn9oL2yU3votRIlO?si=8c14b13f7b8b48b3
November 18, 2024
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NEJM This Week — November 14, 2024

Featuring articles on perioperative durvalumab in bladder cancer, transcatheter valve repair for mitral regurgitation, chemoradiotherapy in gastric cancer, and lessons from England’s National Health Service; a review article on lung transplantation; a case report of a newborn with hypoxemia and a lung opacity; and Perspectives on our latest brief case studies on efforts toward equity and on forensic nurse examiners. Supplement to the New England Journal of Medicine, Vol. 391, No. 19.
November 13, 2024
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Integrating Diagnostics for Global Health Equity with Dr. Ben LaBrot

Ben Plumley sits down with Dr. Benjamin LaBrot to discuss innovation and equity in global health diagnostics, focusing on diagnostics' pivotal role in addressing HIV Disease. The conversation covers key themes in diagnostic integration, barriers in middle-income countries, and the critical role of diagnostics in disease prevention and management for other conditions as well, like hepatitis, and tuberculosis. Host: Ben Plumley, Global Health Strategist Guest: Dr. Benjamin LaBrot, Physician and Global Health Advocate, Roche Diagnostics Key Topics Covered Diagnostics and Patient Empowerment Diagnostics are essential for individual treatment and monitoring, especially for diseases like HIV. LaBrot emphasizes that diagnostics need to evolve to provide integrated testing options for a holistic patient approach. Integration in Global Health Services Dr. LaBrot highlights the need for integrated diagnostic services to reduce fragmentation in healthcare, where separate tests for HIV, STI, hepatitis, and TB are offered. This integration can streamline diagnosis and improve patient care, particularly in low-resource settings. Middle-Income Country Challenges Middle-income countries feel underserved in global health funding and support, often excluded from international resources aimed at lower-income nations. Dr. LaBrot advocates for a more inclusive funding approach, arguing these countries have the infrastructure to maximize benefits from increased diagnostic support. Advances in Diagnostic Technology Dr. LaBrot shares how innovative approaches like plasma data separation cards offer practical solutions for remote and low-resource settings, enabling stable blood sample transport without refrigeration. This innovation bridges the gap between point-of-care testing and lab-based diagnostics, crucial for rural and underserved areas. The Role of Influencers and Education in Health Communication Both Ben Plumley and Dr. LaBrot stress the importance of reaching patients through trusted community influencers and digital platforms. Highlighting Panama’s COVID-19 communication strategy, they underscore how trusted leaders and influencers can combat misinformation and promote health education effectively. Memorable Quotes “In a fragmented healthcare system, diagnostics integration is not just optimal; it’s essential for the effectiveness of any treatment.” - Dr. Ben LaBrot “Middle-income countries feel left out—too well-off to receive international aid but lacking resources to implement comprehensive healthcare.” - Dr. Ben LaBrot Connect with Us If you enjoyed this episode, please subscribe, rate us five stars, and share the conversation on global health equity. For more updates, follow us on LinkedIn, YouTube, and Spotify. Facebook and Instagram: @ShotArmPodcast Youtube: www.youtube.com/@shotarmpodcast LinkedIn: https://www.linkedin.com/company/shotarmpodcast Spotify: https://open.spotify.com/show/69XpqCLn9oL2yU3votRIlO?si=8c14b13f7b8b48b3 Website: www.ashotinthearmpodcast.com Production Team Produced by Erik Espera (NewsDoc Media)  Assistant Producer: Y-Isha Rafael
November 11, 2024
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Post Election Blues & Reds

In this episode, Ben reflects on the recent US Presidential Election and its implications for democracy and global health. Key points discussed include: Democracy in Action: The election showcased the importance of daily democratic engagement in a divided country. Transition Team Priorities: The new administration must focus on health, including rebuilding trust in medical science, pandemic preparedness, and funding frontline services. Global Risks: The triple threats of pandemics, climate change, and conflict pose unprecedented risks to our way of life. AIDS Response: Concerns about the US investment in PEPFAR and the Global Fund, and the need for shared global responsibility to end AIDS. Future of AIDS Response: Plans to launch a dedicated podcast series addressing the long-term AIDS response post-2030, costs, and protecting vulnerable communities. Digital Technology's Role: The significant impact of digital technology and social media on our lives and the need to understand and utilize them effectively. Call to Action: Join Ben, Eric, and the team on this essential journey. Stay tuned for ways to get involved and support their mission. Subscribe: www.youtube.com/@shotarmpodcast
November 7, 2024
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NEJM This Week — November 7, 2024

Featuring articles on an invasive treatment strategy in older patients with myocardial infarction, a randomized trial of very early medication abortion, therapies in stage III melanoma, and on long Covid defined; a review article on uterine fibroids; a Clinical Problem-Solving on two sides to the story; and Perspectives on the U.S. Latino HIV crisis, on reframing cerebral palsy as a lifelong disability, and on an older patient and his physician finding an immediate, resonant connection in a haunting song recalled from long ago and far away. Supplement to the New England Journal of Medicine, Vol. 391, No. 18.
November 6, 2024
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Unlocking the Potential of Clinical Trial Data: New CRDSA Standards

2024-10-31 Clinical Research Data Sharing Alliance (CRDSA) published two new standards earlier this year: the Standard for Sharing Clinical Study Data and the Standard for Secondary Analysis of Clinical Study Data.We held a great discussion on how these standards aim to facilitate the responsible sharing and use of anonymized individual patient data from clinical studies to support the research community and accelerate the discovery and delivery of new therapies to patients. Data Reuse in Regulatory Submissions: The Role of Data Platforms resource was discussed during the live session as well.You can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.
November 4, 2024
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Global Health Diplomats: The 2024 US Election

In this special episode of the Global Health Diplomats, hosted by Ben Plumley and Professor Eric Goosby, the focus is on the upcoming US presidential election and its implications for global health diplomacy. The discussion covers the lack of attention to global health in the current election campaigns, the potential future of global health diplomacy under different administrations, and the critical issues facing global health - the polycrises of pandemics, climate and conflict, as well as the ongoing demands of the global reponse to AIDS. Key Topics Discussed: US Election and Global Health Diplomacy: The lack of attention on global health in the campaigns. The importance of global health for US security and global stability. Future Administration's Role: The risks of vaccine skepticism and hostility to evidence-based decision making that could fundamentally undermine over 50 benefits to society from biomedical research. How realistic is bipartisan support and the challenges in achieving it. Global Health Challenges: The ongoing threat of pandemics and climate-related diseases. The emergence of new and existing infections due to climate change. HIV/AIDS Response: The future of the AIDS response post-2025 and 2030. The need for sustainable funding and local resource mobilization. Ethical and Policy Considerations: The ethical implications of withdrawing support for HIV/AIDS treatment. The importance of evidence-based decision-making in health policy. Call to Action: If you haven't already voted, make a plan to vote and ensure your friends and family do the same. Your vote is crucial for the future of global health and beyond. Production Team: Director and Producer: Erik Espera, NewsDoc Media Production Coordinator and Assistant Producer: Y-Isha Rafael Closing Remarks: Ben and Eric emphasize the importance of voting and staying safe. They promise to return with more discussions on what needs to happen next in global health diplomacy. Listen to the full episode for an in-depth discussion on these critical issues and more. You can also watch the video at youtube.com/@shotarmpodcast or on Spotify.
November 3, 2024
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NEJM This Week — October 31, 2024

Featuring articles on semaglutide in persons with obesity and knee osteoarthritis, the addition of PI3K inhibition in breast cancer, treatments in older patients with myeloma, and total hip replacement for hip osteoarthritis; a review article on lead poisoning; a case report of a man with dyspnea after old myocardial infarction; and Perspectives on large language models and the medical record, on measuring AI against the health care we have, on the failing U.S. health system, and on the contemporary rise of pronatalism. Supplement to the New England Journal of Medicine, Vol. 391, No. 17.
October 30, 2024
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NEJM This Week — October 24, 2024

Featuring articles on treatments in heart failure, advanced non–small-cell lung cancer, and Dupuytren’s contracture; a neurodevelopmental disorder caused by deletion in a long noncoding RNA; a review article on burnout and depression among physicians; a case report of a woman with confusion, aphasia, and a brain mass; a Medicine and Society article on how the idea of social contagion shaped trans medicine; and Perspectives on navigating clinicians’ conscience-based refusals, on opportunity costs of Medicare Advantage rebates, on celebrating public health, and on taking our own medicine. Supplement to the New England Journal of Medicine, Vol. 391, No. 16.
October 23, 2024
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NEJM This Week — October 17, 2024

Featuring articles on nivolumab in advanced Hodgkin’s lymphoma, kidney transplantation from donors with HIV, a modular communicative leadless pacing–defibrillator system, stereotactic body radiotherapy in prostate cancer, and on how DNA sensing drives inflammation; a review article on cryoglobulinemia; a case report of a woman with dyspnea, dysphagia, and dysarthria; and a Special Report and Perspectives on the U.S. elections and health policy.
October 16, 2024
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The Venn Diagram of Point of Care Trials, DCTs, and RWE

2024-10-10 Hosts Craig Lipset, Dr. Amir Kalali, and Jane Myles were joined by Matt Veatch and Aaron Kamauu, hosts of the Real World Wednesday's Club on Clubhouse. We joined forces for a TGIF-DTRA + RWW Crossover Episode! With the release of the FDA Draft Guidance on Integrating Randomized Controlled Trials for Drug and Biological Products Into Routine Clinical Practice, it was the perfect topic to bring together the DCT and RWE community for a conversation around this guidance. We discussed why this guidance was aligned to RWE, the distinctions between decentralized, pragmatic, point-of-care trials, and real-world evidence, and how RCTs and DCTs can drive access for all patients.Read the guidance here --> https://www.fda.gov/media/181871/downloadYou can join TGIF-DTRA Sessions live on LinkedIn Live Audio on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.
October 15, 2024
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Sharing the Mic with Frontline AIDS: Africa’s Forgotten Mpox Outbreaks

We are Sharing The Mic again with Frontline AIDS to highlight the latest mpox outbreaks that have started in the Democratic Republic of Congo, spread to Burundi and beyond. From lack of access to accurate, updated information, diagnostics - and of course - vaccines, communities - particularly partners of Frontline AIDS - are calling out for urgent, concerted action from governments, and international agencies, including the WHO. Joining Ben are: Ntombizodwa Mthembu, Programs Adviser, Frontline AIDS Aggrey Aluso, Pandemic Action Network, Director, Africa Region, Kenya Dr. Egide Haragirimana, Co-Founder & Co-Chair Village Health Action, Burundi. https://frontlineaids.org https://www.pandemicactionnetwork.org https://www.vh-a.org #mpox #vaccineaccess #commodities #communityleadership #healthequity
October 14, 2024
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