2024-03-22 Hosts Craig Lipset and Jane Myles dove into a conversation with Andrew Mackinnon (Medable) about their work with Duke on patient preference in an eConsent study. Learn more about the Pilot Study here --> https://pilotfeasibilitystudies.biomedcentral.com/articles/10.1186/s40814-023-01432-wFollow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
March 25, 2024
Featuring articles on autism and prenatal exposure to antiseizure medication, ribociclib plus endocrine therapy in early breast cancer, gene therapy for giant axonal neuropathy, and anti–interleukin-23 in immunodeficiency; a review article on wearable digital health technologies in clinical care; a case report of a man with a fall; and Perspective articles on physicians, spirituality, and compassionate care; on the risks posed by immediate release of test results to patients; and on what one author did not tell the medical student. Supplement to the New England Journal of Medicine, Vol. 390, No. 12.
March 20, 2024
2024-03-15 Hosts Craig Lipset and Jane Myles were joined by Jonathan Ernst (PCM Trials) and Ghazala Kabani (Integrity ClinOps Consulting) for a discussion around the growing interest and excitement for decentralized clinical trials in Pakistan.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
March 18, 2024
ViiV Healthcare is the world’s only pharmaceutical company dedicated exclusively to HIV, and in this episode, Ben meets its CEO, Deborah Waterhouse, to explore the company’s approach to HIV R&D and commercial success - as well as the controversies its global access strategy has attracted for its new long acting injectables. Deborah and Ben find they have much in common beyond both being Brits growing up in the 70s and 80s, from being students of the humanities choosing to make careers in health, to their favorite pop music.
https://viivhealthcare.com
https://www.unaids.org/en
https://www.who.int/health-topics/hiv-aids
https://www.cdc.gov/hiv/default.html
https://au.int/en/sa/oid
#ViiV #pharma #HIV #AIDS #treatment #Prevention #PrEP #dualtherapy #longacting #injectables #globalaccess #globalequity #discrimination #positiveaction #womenleaders #IWD
March 13, 2024
Featuring articles on a blood-based test for colorectal cancer screening, a multitarget stool DNA test for colorectal cancer, iptacopan for paroxysmal nocturnal hemoglobinuria, and preterm birth and other outcomes of maternal RSV vaccination; a review article on cerebral cavernous malformations; a case report of a man with cardiac arrest, cardiogenic shock, and hypoxemia; and Perspective articles on vertical integration and American medicine; on aspirin, preeclampsia, and racism; and on a shift in the night. Supplement to the New England Journal of Medicine, Vol. 390, No. 11.
March 13, 2024
2022-04-29 Hosts Amir Kalali and Craig Lipset were joined by Shawn Tedman (ixlayer) and Beth Culver (MRN) to discuss lab specimens and the logistics of obtaining them from patients when the trials are being run from home.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
March 8, 2024
This International Women’s Day, we’re sharing the mic with Frontline AIDS. Yvette Raphael reflects on the challenges and setbacks girls and women face around the world in 2024, in a hard hitting conversation with Frontline AIDS’ Yumnah Hattas, Toyin Chukwudozie Executive Director of Nigeria’s Education As A Vaccine, and Beirne Roose-Snyder, Senior Director of the Preclusion Project.
https://frontlineaids.org
https://www.evanigeria.org
https://apha.org.za
https://www.thepreclusionproject.org
https://www.unaids.org/en
https://www.state.gov/pepfar
https://www.project2025.org
#IWD #HIV #AIDS #pepfar #womensrights #antiabortion #forcedbirth #neocolonialism #reproductivehealth #choiceagenda
March 8, 2024
Featuring articles on an antibody–drug conjugate in untreated urothelial cancer, omalizumab for multiple food allergies, microplastics and nanoplastics in carotid plaque, and benralizumab or mepolizumab for eosinophilic granulomatosis with polyangiitis; a review article on the health effects of endocrine-disrupting chemicals; a Clinical Problem-Solving on peeling and plummeting; a Medicine and Society on beyond moral injury; and a Perspective article on eugenics in the Journal. Supplement to the New England Journal of Medicine, Vol. 390, No. 10.
March 6, 2024
Ongoing research is shedding light on the complex dimensions of structural resilience. In this episode, we are joined by Dr. Kamila Alexander, an Associate Professor at Johns Hopkins School of Nursing. Dr. Alexander's research focuses on understanding how socio-structural factors impact health outcomes of marginalized youth, particularly regarding trauma, violence, and sexual, mental, and reproductive health. She shares insights from her work on how communities can overcome challenges, utilize resources, and promote sustainable development despite facing adversity.
References
Alexander KA et al. Intervention Approaches to Address Intimate Partner Violence and HIV: a Scoping Review of Recent Research. Current HIV/AIDS Reports. September 2023.
Alexander KA et al. Contraceptive Use Among Women Experiencing Intimate Partner Violence and Reproductive Coercion: The Moderating Role of PTSD and Depression. Violence Against Women. February 2023.
Alexander KA et al. Having a Child Meant I had a Real Life: Reproductive Coercion and Childbearing Motivations Among Young Black Men Living in Baltimore. Journal of Interpersonal Violence. June 2019.
Alexander KA, Szanton SL, et al. Life Space and Activity Space Measurement: Making ‘Room’ for Structural Racism. The Gerontogist. November 2023.
March 4, 2024
2024-03-01 Hosts Craig Lipset, Amir Kalali, and Jane Myles were joined by Dr. Rohit Aggarwal to share his experience and expertise regarding the MINT study and the work he has accomplished thus far in the rare disease space.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
March 4, 2024
In the next of our podcasts dedicated to the USA’s multibillion investment in the fight against AIDS, Ben and Yvette catch up with Emily Bass, author of To End A Plague - the definitive history of PEPFAR, to discuss how PEPFAR, the pride of US bipartisanship, has become yet another victim of congressional mischief-making. PEPFAR saves lives: it also reinforces US soft power abroad. So why would politicians want to scupper it?
https://www.state.gov/pepfar
https://apha.org.za
https://www.emilybass.club
Find out more about Emily’s book “To End A Plague”,
Check out our 2022 interview with her https://youtu.be/YSzO3NWQeI0?si=6oKAfO4aoazQd8EO
#pepfar #HIV #AIDS #stigma #discrimination #Prevention #treatment #bipartisanship #US #Congress
March 3, 2024
Featuring articles on a trial of seladelpar in primary biliary cholangitis, a trial of elafibranor in primary biliary cholangitis, cognition and memory after Covid-19, and simple versus radical hysterectomy in women with low-risk cervical cancer; a review article on cardiac rehabilitation; a case report of a woman with alternating sixth cranial nerve palsy; and a Perspective article on practicing medicine in the culture wars. We also describe a new cases series on efforts toward equity in health care.Supplement to the New England Journal of Medicine, Vol. 390, No. 9.
February 28, 2024
2024-02-23 Join hosts Jane Myles and Joe Dustin for a conversation with Noelle Gaskill (BMS) around site centric DCT approaches and how some key components could make a hybrid DCT successful in interventional oncology.
February 26, 2024
Featuring articles on CD19 CAR T-cell therapy in autoimmune disease, tenecteplase for stroke at 4.5 to 24 hours, biomarker changes in years before Alzheimer’s disease, and a hepcidin mimetic in polycythemia vera; a review article on wearable digital health technologies for epilepsy; a case report of a man with fatigue and night sweats; and Perspective articles on direct-to-consumer platforms for antiobesity medications, on childhood obesity prevention, and on what is a mentor. Supplement to the New England Journal of Medicine, Vol. 390, No. 8.
February 21, 2024
2024-02-16 Hosts Craig Lipset and Jane Myles were joined by Vik Kheterpal (CareEvolution), Dr. Apruv Soni (Univers of Mass.), and Dr. Ed Ramos to discuss findings and data from digital studies/interventions that can really address inequities in healthcare and reaching underserved populations.A great conversation was had about expanding the dialogue around the digital ecosystem for healthcare innovation.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
February 19, 2024
Recorded in June 2023, Yvette Raphael and Ben Plumley catch up with Dr. Frank Mugisha, a leading Ugandan advocate at the forefront of the fight against the country’s persecution of the LGBTQ+ community. After the Uganda Anti-Homosexuality Bill became law in Uganda, Frank explains the direct threats to the safety of the LGBTQ+ Ugandans and their supporters. He points to the outsize funding and influence of Western, particularly North American, right-wing Christian evangelists. The conversation serves, not only as an insight into the growing anti-rights movement that targets women’s as well as LGBTQ+ rights, but also a call to action to other pro-rights African leaders to stand up and be counted. How can the end of AIDS be achieved by 2030, if disproportionately affected communities are persecuted and driven underground?
https://smuginternational.org
https://www.state.gov/pepfar
https://www.unaids.org/en
https://frontlineaids.org
https://global-listening.org
https://www.splcenter.org/fighting-hate/extremist-files/group/family-watch-international
#LGBTQ #Uganda #anti-homosexualitylaw #HIV #AIDS #marginalisedcommunities #neocolonialism #extremism #Africansolidarity
February 18, 2024
Featuring articles on frexalimab in multiple sclerosis, e-cigarettes for smoking cessation, cefepime–taniborbactam for complicated UTI, and the treatment of Wolman’s disease in an infant; review articles on treatment-resistant depression in older adults and on Behçet’s syndrome; a case report of a man with fevers; and Perspective articles on ethical issues in safety-net health systems, on secondary cancers after CAR T-cell therapy, and on being worried about white-cell counts. Supplement to the New England Journal of Medicine, Vol. 390, No. 7.
February 14, 2024
The Global Listening Project has teamed up with the Global Health Diplomats and A Shot In The Arm Podcast, to bring you the release of the Project’s new 70 country 70,000 people study into how public trust in governments and health policies have been affected by COVID-19. It’s the first data set of this size to capture comprehensive information about people’s sense of preparedness for future crises. Coming just before the Munich Security Conference, Co-host Ben Plumley catches up with GLP founder, Professor Heidi Larson in Bengaluru, along with friend of the podcast, Prasada Rao JVR, former Health Secretary of India, and Professor Balaji Parthasarthy, International Institute of Information Technology Bangalore, to explore why we are witnessing a global trust crisis - and why it its urgent for human security to address this.
https://global-listening.org
https://www.iiitb.ac.in
https://securityconference.org/en
https://securityconference.org/en/publications/munich-security-report-2024
#security #humansecurity #globalsecurity #globalhealthsecurity #pandemicpreparedness #climatedisruption #conflict #trust #india #munichsecurityconference
February 14, 2024
2024-02-09 Hosts Craig Lipset and Jane Myles were joined by Stephen Sundquist (3CTN) and Bianka Courcelle (HSJ) to discuss the PI site perspective and experiences in implementing a trial cluster involving a satellite site in supporting patient access. The specific clinical trial case illustrates how the CRAFT hybrid DCT approach was applied to support collaboration between the pediatric cancer centre and an adult centre in supporting an AYA patient on trial. A great conversation was had about how the CRAFT hybrid DCT Framework; why it was built, how it was constucted, and why it matters.Site Supervision Template: https://3ctn.ca/wp-content/uploads/2022/04/CRAFT-Site-Supervision-Plan_WM.pdfCRAFT Framework: https://3ctn.ca/for-researchers/craft/Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
February 12, 2024
In the first of an informal series of episodes looking at the PEPFAR & US global AIDS funding, Ben chats with Dr Anu Kumar, President & CEO of IPAS, on how the US Supreme Court’s repeal of Roe vs Wade has mobilized extremist neo-colonial efforts to reverse HIV, safe abortion services and global health programs particularly in sub Saharan Africa.
https://www.ipas.org
https://www.state.gov/pepfar
https://www.emilybass.club/book
https://www.unaids.org/en
#pepfar #HIV #AIDS #SRHR #abortion #safeabortion #RoeVsWade #LGBT
February 11, 2024
Upcoming episodes of A Shot In The Arm and Global Health Diplomats podcasts are focusing on PEPFAR - the US multi-billion investment in helping countries hardest hit by the AIDS epidemic, and saving tens of millions of lives. Its future funding is precarious, stalled in Congress - and we will explore the massive impact it has had, how it became the poster child for bipartisanship in Washington DC - and how allies of all political stripes can get it back on track.
February 11, 2024
Featuring articles on a phase 3 trial of resmetirom in NASH with liver fibrosis, an interleukin-23–receptor antagonist for plaque psoriasis, the neurovascular complications of F. solani meningitis, and on ocular gene therapy; a review article on coccidioidomycosis and histoplasmosis; a case report of a man with fever and headache after international travel; Medicine and Society articles on a physician attack on the FDA and on being well while doing well; and Perspective articles on the risks of normalizing parental vaccine hesitancy, on advanced HIV as a neglected disease, on the challenge of common chronic diseases, and on “the saddest waste”. Supplement to the New England Journal of Medicine, Vol. 390, No. 6.
February 7, 2024
This episode delves into the powerful connection between resilience and civic engagement that enables underserved communities to not just withstand systemic challenges but to emerge stronger. Our guest for this conversation is Dr. Hahrie Han, the Director of the SNF Agora Institute and a Professor of Political Science at Johns Hopkins University. Dr. Han explores how grassroots organizations transform community engagement into political influence. Join us as we explore the juncture of societal structures, grassroots movements, and the enduring resilience of communities striving for a more equitable future.
References
Han H, Kim, JY, de Vries, M. The unequal landscape of civic opportunity in America. Nature Human Behavior. November 2023.
Han H, McKenna E, Oyakawa M. Prisms of the People. University of Chicago Press. 2021.
February 5, 2024
2024-02-02 Hosts Craig Lipset and Jane Myles were joined by Chunky Satija (Everest Group) for a discussion around mergers & acquisitions in the DCT space and what we may see on the horizon as the market evolves throughout the year.Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and Twitter. Learn more about Membership and our work at www.dtra.org.
February 5, 2024